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Transdermal Delivery System For Use With Basic Permeation Enhancers

  • US 20080138390A1
  • Filed: 04/07/2005
  • Published: 06/12/2008
  • Est. Priority Date: 04/07/2004
  • Status: Abandoned Application
First Claim
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1. A transdermal delivery system for administering an active agent through the body surface, comprising:

  • (a) a polymeric matrix that serves as both an active agent reservoir and a skin contact adhesive layer, wherein the matrix comprises a substantially homogeneous mixture of a polyisobutylene rubber and an insoluble hydrophilic polymer in the form of a powder having a particle size in the range of about 1 micron to 300 microns;

    (b) a pharmaceutical formulation absorbed in the polymeric matrix which comprises a therapeutically effective amount of the active agent, an effective flux-enhancing amount of a basic permeation enhancing composition, and a pharmaceutically acceptable aqueous vehicle; and

    (c) a backing layer laminated to the polymeric matrix that serves as the outer surface of the device use.

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