RECOMBINANT BONE MORPHOGENETIC PROTEIN HETERODIMERS, COMPOSITIONS AND METHODS OF USE
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Abstract
The present invention relates to methods for producing recombinant heterodimeric BMP proteins useful in the field of treating bone defects, healing bone injury and in wound healing in general. The invention also relates to the recombinant heterodimers and compositions containing them.
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Citations
38 Claims
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1-36. -36. (canceled)
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37. An isolated recombinant heterodimeric protein having bone stimulating activity comprising a bone morphogenetic protein-2 comprising amino acids 283-396 of SEQ ID NO:
- 2, or a fragment thereof, associated by at least one disulfide bond with a bone morphogenetic protein-6 comprising amino acids 375-513 of SEQ ID NO;
8, or a fragment thereof. - View Dependent Claims (38)
- 2, or a fragment thereof, associated by at least one disulfide bond with a bone morphogenetic protein-6 comprising amino acids 375-513 of SEQ ID NO;
Specification