Multi-Wavelength Spatial Domain Near Infrared Oximeter to Detect Cerebral Hypoxia-Ischemia
First Claim
1. A method for measuring brain oxygen saturation using multi-wavelength near infrared spectroscopy (NIRS), comprising the steps of:
- sending light of a first near infrared wavelength through an amount of brain tissue, with the assistance of a near infrared light emitter;
measuring a first set of at least three intensities of the light of the first near infrared wavelength that passes through the brain tissue, with the assistance of at least three photodiode detectors positioned at least three distances from the near infrared light emitter;
sending light of a second near infrared wavelength through an amount of brain tissue, with the assistance of the near infrared light emitter;
measuring a second set of at least three intensities of the light of the second near infrared wavelength that passes through the brain tissue, with the assistance of the at least three photodiode detectors positioned at the at least three distances from the near infrared light emitter;
sending light of a third near infrared wavelength through an amount of brain tissue, with the assistance of the near infrared light emitter;
measuring a third set of at least three intensities of the light of the third near infrared wavelength that passes through the brain tissue, with the assistance of at least three photodiode detectors positioned at the at least three distances from the near infrared light emitter; and
calculating a saturation of tissue oxygenation using an algorithm derived from the Beer-Lambert law and based at least upon one or more ratios of measured intensities at two or more near infrared wavelengths and one or more ratios of measured intensities at two or more photodiode detectors.
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Accused Products
Abstract
Methods and apparatus for measuring cerebral O2 saturation and detecting cerebral hypoxia-ischemia using multi-wavelength near infrared spectroscopy (NIRS). Near-infrared light produced by an emitter is directed through brain tissue. The intensity of the light that passes through the brain tissue is measured using photodiode detectors positioned at distinct distances from the emitter. This process is conducted for at least three wavelengths of near-infrared light. One of the wavelengths used is substantially at an isobestic point for oxy-hemoglobin and deoxy-hemoglobin, but the other two may be any wavelengths within the near-infrared spectrum (700 nm to 900 nm), so long as one of the additional wavelengths is greater than the isobestic point and the other is less than the isobestic point. Tissue oxygenation is calculated using an algorithm derived from the Beer-Lambert law. Cerebral hypoxia-ischemia may be diagnosed using the calculated tissue oxygenation value.
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Citations
20 Claims
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1. A method for measuring brain oxygen saturation using multi-wavelength near infrared spectroscopy (NIRS), comprising the steps of:
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sending light of a first near infrared wavelength through an amount of brain tissue, with the assistance of a near infrared light emitter; measuring a first set of at least three intensities of the light of the first near infrared wavelength that passes through the brain tissue, with the assistance of at least three photodiode detectors positioned at least three distances from the near infrared light emitter; sending light of a second near infrared wavelength through an amount of brain tissue, with the assistance of the near infrared light emitter; measuring a second set of at least three intensities of the light of the second near infrared wavelength that passes through the brain tissue, with the assistance of the at least three photodiode detectors positioned at the at least three distances from the near infrared light emitter; sending light of a third near infrared wavelength through an amount of brain tissue, with the assistance of the near infrared light emitter; measuring a third set of at least three intensities of the light of the third near infrared wavelength that passes through the brain tissue, with the assistance of at least three photodiode detectors positioned at the at least three distances from the near infrared light emitter; and calculating a saturation of tissue oxygenation using an algorithm derived from the Beer-Lambert law and based at least upon one or more ratios of measured intensities at two or more near infrared wavelengths and one or more ratios of measured intensities at two or more photodiode detectors. - View Dependent Claims (2, 3, 4, 5)
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6. A method for measuring brain oxygen saturation using multi-wavelength near infrared spectroscopy (NIRS), comprising the steps of:
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(a) sending light of a first near infrared wavelength through an amount of brain tissue, with the assistance of a near infrared light emitter; (b) measuring a first intensity of the light of the first near infrared wavelength that passes through the brain tissue, with the assistance of a first photodiode detector positioned a first distance from the near infrared light emitter; (c) measuring a second intensity of the light of the first near infrared wavelength that passes through the brain tissue, with the assistance of a second photodiode detector positioned a second distance from the near infrared light emitter; (d) measuring a third intensity of the light of the first near infrared wavelength that passes through the brain tissue, with the assistance of a third photodiode detector positioned a third distance from the near infrared light emitter; (e) repeating steps (a) through (d) a plurality of times for light of a corresponding plurality of near infrared wavelengths; and (f) calculating a saturation of tissue oxygenation using an algorithm derived from the Beer-Lambert law and based at least upon one or more ratio of measured intensities at two or more of the near infrared wavelengths and one or more ratios of measured intensities at the two or more photodiode detectors. - View Dependent Claims (7, 8)
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9. A method for measuring brain oxygen saturation using multi-wavelength near infrared spectroscopy (NIRS), comprising the steps of:
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(a) sending light of a first near infrared wavelength through an amount of brain tissue, with the assistance of a near infrared light emitter; (b) measuring a first set of a plurality of intensities of the light of the first near infrared wavelength that passes through the brain tissue, with the assistance of a plurality of photodiode detectors positioned at corresponding plurality distances from the near infrared light emitter; (c) repeating the steps (a) and (b) for light of a plurality of near infrared wavelengths; and (d) calculating a saturation of tissue oxygenation using an algorithm derived from the Beer-Lambert law and based at least upon one or more ratios of measured intensities at two or more of the near infrared wavelengths and one or more ratios of measured intensities at two or more of the photodiode detectors. - View Dependent Claims (10, 11, 12)
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13. A method for measuring brain oxygen saturation using multi-wavelength near infrared spectroscopy (NIRS), comprising the steps of:
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sending light of a first near infrared wavelength through an amount of brain tissue, with the assistance of a near infrared light emitter; measuring a first intensity of the light of the first near infrared wavelength that passes through the brain tissue, with the assistance of a first photodiode detector positioned a first distance from the near infrared light emitter; measuring a second intensity of the light of the first near infrared wavelength that passes through the brain tissue, with the assistance of a second photodiode detector positioned a second distance from the near infrared light emitter; measuring a third intensity of the light of the first near infrared wavelength that passes through the brain tissue, with the assistance of a third photodiode detector positioned a third distance from the near infrared light emitter; sending a light of a second near infrared wavelength through the amount of brain tissue, with the assistance of the near infrared light emitter; measuring a fourth intensity of light of the second near infrared wavelength that passes through the brain tissue, with the assistance of the first photodiode detector positioned the first distance from the near infrared light emitter; measuring a fifth intensity of light of the second near infrared wavelength that passes through the brain tissue, with the assistance of the second photodiode detector positioned the second distance from the near infrared light emitter; measuring a sixth intensity of light of the second near infrared wavelength that passes through the brain tissue, with the assistance of the third photodiode detector positioned the third distance from the near infrared light emitter; sending a light of a third near infrared wavelength through the amount of brain tissue, with the assistance of the near infrared light emitter; measuring a seventh intensity of light of the third near infrared wavelength that passes through the brain tissue, with the assistance of the first photodiode detector positioned the first distance from the near infrared light emitter; measuring an eighth intensity of light of the third near infrared wavelength that passes through the brain tissue, with the assistance of the second photodiode detector positioned the second distance from the near infrared light emitter; measuring a ninth intensity of light of the third near infrared wavelength that passes through the brain tissue, with the assistance of the third photodiode detector positioned the third distance from the near infrared light emitter; and calculating a saturation of tissue oxygenation using an algorithm derived from the Beer-Lambert law and based at least upon one or more ratios of measured intensities at two or more of the near infrared wavelengths and one or more ratios of measured intensities at two or more of the photodiode detectors. - View Dependent Claims (14, 15, 16, 17, 18)
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19. An apparatus for measuring brain oxygen saturation comprising:
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a probe housing; a near-infrared light emitter housed within the probe housing; a first photodiode detector positioned a first distance from the emitter; a second photodiode detector positioned at a second distance from the emitter, the second distance being longer than the first distance; and a third photodiode detector positioned at a third distance from the emitter, the third distance being longer than the second distance. - View Dependent Claims (20)
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Specification