SURFACE TREATMENT OF MEDICAL DEVICES

• US 20080142038A1
• Filed: 10/25/2007
• Published: 06/19/2008
• Est. Priority Date: 12/15/2006
• Status: Abandoned Application

• Current Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Original Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Inventors: Stachowski, Mark, Kunzler, Jay F., Linhardt, Jeffrey G., Salamone, Joseph C.
• Application Number:
  US11/924,336
• Publication Number:
  US 20080142038A1
• Time in Patent Office: Days
• US Class Current: 134/1.1
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: C08J 2383/04 Polysiloxanes
• CPC Class Codes: C08J 7/0427 with only one layer of a composition containing a polymer binder with more layers C08J7/042
• CPC Class Codes: C08J 7/043 Improving the adhesiveness of the coatings per se, e.g. forming primers adhesives in the form of films or foils characterised by the primer layers between the polymer carriers and the adhesives C09J7/50
• CPC Class Codes: C08J 7/056 Forming hydrophilic coatings
• CPC Class Codes: C08J 7/14 with acids, their salts or anhydrides
• CPC Class Codes: G02B 1/043 Contact lenses

Abstract

A method for improving the wettability of a medical device is provided, the method comprising the steps of (a) providing a medical device formed from a monomer mixture comprising a hydrophilic monomer and a siloxy-containing monomer, (b) subjecting a surface of the medical device to a surface treatment, and (c) contacting the treated surface of the medical device with a wetting agent solution comprising a carboxylic acid-containing polymer or copolymer to form a carboxylic acid-containing polymeric or copolymeric layer on the treated surface of the medical device.

Claims

1. A method for improving the wettability of a medical device, the method comprising the steps of (a) providing a medical device formed from a monomer mixture comprising a hydrophilic monomer and a siloxy-containing monomer, (b) subjecting a surface of the medical device to a surface treatment to provide reactive functionalities on the surface of the medical device, and (c) contacting the treated surface of the medical device with a wetting agent solution comprising a carboxylic acid-containing polymer or copolymer to form a carboxylic acid-containing polymeric or copolymeric layer on the treated surface of the medical device.

2. The method of claim 1, wherein the medical device comprises in bulk formula about 5 to about 50 percent by weight of one or more silicone macromonomers and about 5 to about 50 percent by weight of a hydrophilic monomer.

3. The method of claim 2, wherein the hydrophilic monomer is selected from the group consisting of unsaturated carboxylic acids, vinyl lactams, acrylamides, polymerizable amines, vinyl carbonate or vinyl carbamate, oxazolone monomers, and mixtures thereof.

4. The method of claim 2, wherein the hydrophilic monomer is selected from the group consisting of methacrylic and acrylic acids, 2-hydroxyethylmethacrylate, N-vinylpyrrolidone, methacrylamide, N,N-dimethylacrylamide, and mixtures thereof.

5. The method of claim 1, wherein the surface treatment comprises oxidation of the surface with a nitrogen or oxygen-containing oxidizing gas.

6. The method of claim 5, wherein the oxygen-containing or nitrogen-containing gas selected comprises one or more of ambient air, oxygen gas, ammonia, hydrogen peroxide, alcohol, and water.

7. The method of claim 1, wherein the carboxylic acid-containing polymer or copolymer in the wetting agent solution is characterized by an acid content of at least about 40 mole percent.

8. The method of claim 1, wherein the polymer or copolymer of acrylic acid is selected from the group consisting of poly(N-vinylpyrolidinone(NVP)-co-acrylic acid(AA)), poly(methylvinyl ether-alt-maleic acid), poly(acrylic acid-graft-ethylene oxide), poly(acrylic acid-co-methacrylic acid), poly(acrylamide-co-AA), poly(acrylamide-co-methacrylic acid), and poly(butadiene-co-maleic acid).

9. The method of claim 1, further comprising acidifying the solution of step (c) to provide a solution pH of less than about 5.

10. The method of claim 1, wherein the medical device is an opthalmic lens.

11. The method of claim 10, wherein the opthalmic lens is a contact lens.

12. The method of claim 11, wherein the contact lens is a silicone hydrogel lens.

13. A method for improving the wettability of a medical device, the method comprising the steps of (a) providing a medical device formed from a monomer mixture comprising a hydrophilic monomer and a siloxy-containing monomer, (b) subjecting a surface of the medical device to a surface treatment, and (c) contacting the treated surface of the medical device with a wetting agent solution comprising a carboxylic acid-containing polymer or copolymer to form a carboxylic acid-containing polymeric or copolymeric layer on the treated surface of the medical device.

14. The method of claim 13, wherein the medical device comprises in bulk formula about 5 to about 50 percent by weight of one or more silicone macromonomers and about 5 to about 50 percent by weight of a hydrophilic monomer.

15. The method of claim 13, wherein the carboxylic acid-containing polymer or copolymer is characterized by an acid content of at least about 40 mole percent.

16. The method of claim 15, wherein the carboxylic acid-containing polymer or copolymer is characterized by acid content of at least about 50 mole percent.

17. A method for improving the wettability of a medical device, the method comprising the steps of (a) providing a medical device formed from a monomer mixture comprising a siloxy-containing monomer and at least one hydrophilic monomer selected from the group consisting of N-vinyl-2-pyrrolidone and N,N-dimethylacrylamide, (b) subjecting a surface of the medical device to a surface treatment, and (c) contacting the treated surface of the medical device with a wetting agent solution comprising a carboxylic acid-containing polymer or copolymer to form a carboxylic acid-containing polymeric or copolymeric layer on the treated surface of the medical device.

18. The method of claim 17, wherein the surface treatment comprises oxidation of the surface with a nitrogen or oxygen-containing oxidizing gas.

19. The method of claim 17, wherein the wetting agent solution comprises at least one polymer selected from the group consisting of poly(acrylic acid) and poly(acrylic acid-co-acrylamide).

20. The method of claim 17, further comprising acidifying the solution of step (c) to provide a solution pH of less than about 5.