Lateral flow assay device
First Claim
1. A lateral flow assay device that further includes:
- a housing, and a test strip disposed within said housing comprising a membrane with a detection region and a collection region;
a sample meter comprising a first end for absorption of a test sample, and a storage section that receives and stores at least a component of the test sample;
an opening in said housing sized for insertion of said sample meter into said housing such that said storage section of said sample meter is disposed adjacent said collection region of said membrane, the test sample component transferable from said storage section to said collection region for subsequent migration to said detection region; and
an activatable isolation mechanism within said housing and disposed so as to isolate portions of said sample meter storage section upon activation thereof such that a defined length of said storage section is presented to said collection region of said membrane.
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Accused Products
Abstract
A lateral flow assay device includes a housing, and a test strip disposed within the housing having a membrane with a detection region and a collection region. A sample meter includes a first end for absorption of a test sample, and a storage section that receives and stores at least a component of the test sample. An opening in the housing is sized for insertion of the sample meter into the housing such that the storage section of the sample meter is disposed adjacent the collection region of the membrane. The test sample component is transferable from the storagesection to the collection region for subsequent migration to the detection region. An activatable isolation mechanism is provided within the housing and is disposed so as to isolate portions of the sample meter storage section upon activation thereof such that a defined length of the storage section is presented to the collection region of the membrane.
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Citations
21 Claims
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1. A lateral flow assay device that further includes:
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a housing, and a test strip disposed within said housing comprising a membrane with a detection region and a collection region; a sample meter comprising a first end for absorption of a test sample, and a storage section that receives and stores at least a component of the test sample; an opening in said housing sized for insertion of said sample meter into said housing such that said storage section of said sample meter is disposed adjacent said collection region of said membrane, the test sample component transferable from said storage section to said collection region for subsequent migration to said detection region; and an activatable isolation mechanism within said housing and disposed so as to isolate portions of said sample meter storage section upon activation thereof such that a defined length of said storage section is presented to said collection region of said membrane. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for performing a lateral flow assay on a test sample of less than about 10 microliters to detect the presence of an analyte in the test sample, the method comprising:
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exposing an end of a sample meter to the test sample, the sample meter absorbing the sample, separating certain components from the sample, and saving the remaining portion of the sample in a storage section of the sample meter; inserting the sample meter into a lateral flow assay device having a test strip with a collection region and a detection region; isolating a part of the storage section of the sample meter so as to define a metered length of the storage section; presenting the metered length of the storage section in fluid communication with the collection region of the test strip while supplying a diluent to the collection region; and whereby the sample is transferred from the metered length of the storage section of the sample meter to the collection region of the membrane and migrates to the detection region of the membrane. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21)
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Specification