COATED IMPLANTABLE MEDICAL DEVICE
First Claim
1. An implantable medical device, comprising:
- a structure adapted for introduction into a patient, the structure having at least one surface;
at least one layer of an immunosuppressive agent posited over the at least one surface of the structure; and
at least one porous layer posited over the at least one layer of an immunosuppressive agent.
5 Assignments
0 Petitions
Accused Products
Abstract
A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
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Citations
21 Claims
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1. An implantable medical device, comprising:
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a structure adapted for introduction into a patient, the structure having at least one surface; at least one layer of an immunosuppressive agent posited over the at least one surface of the structure; and at least one porous layer posited over the at least one layer of an immunosuppressive agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A medical device comprising:
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a stent adapted for introduction into a patient, the stent having at least one surface; at least one layer of an immunosuppressive agent posited over the at least one surface of the stent; and at least one porous layer posited over the at least one layer of an immunosuppressive agent. - View Dependent Claims (13, 14, 15, 16, 17, 18)
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19. A medical device comprising:
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a stent adapted for introduction into a patient, the stent having at least one surface; at least one layer of an immunosuppressive agent posited over the at least one surface of the stent; at least one porous layer posited over the at least one layer of an immunosuppressive agent; and at least one coating layer posited over the at least one surface of the stent; wherein the at least one layer of an immunosuppressive agent is posited over at least a portion of the at least one coating layer, wherein the at least one layer of the immuno-suppressive agent is adsorbed on or absorbed into the at least one coating layer, and wherein the at least one coating layer provides for a controlled release of the immunosuppressive agent from the at least one layer of the immunosuppresive agent.
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20. A medical device comprising:
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a stent adapted for introduction into a patient, the stent having at least one surface; at least one layer of an immunosuppressive agent posited over the at least one surface of the stent; at least one porous layer posited over the at least one layer of an immunosuppressive agent; and at least one coating layer posited over the at least one surface of the stent; wherein the at least one layer of an immunosuppressive agent is posited over at least a portion of the at least one coating layer, wherein the at least one layer of an immunosuppressive agent is adsorbed on or absorbed into the at least one coating layer, and wherein the at least one coating layer provides for a controlled release of the immunosuppressive agent from the at least one layer of an immunosuppresive agent; wherein the at least one coating layer has a thickness in a range from 50,000 to 500,000 Angstroms; wherein the at least one porous layer is composed of a polymer; and wherein the stent further comprises at least one well formed in the at least one surface of the stent, the at least one well being a groove or slot in which the immunosuppressive agent of the at least one layer of an immunosuppressive agent is contained.
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21. An implantable medical device, comprising:
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a structure adapted for introduction into a patient, the structure having at least one surface; at least one layer of an immunosuppressive agent posited over the at least one surface of the structure; at least one coating layer posited over the at least one surface of the structure; and at least one porous layer posited over the at least one layer of an immunosuppressive agent; wherein the at least one layer of an immunosuppressive agent is posited over at least a portion of the at least one coating layer and the at least one coating layer provides for a controlled release of the immunosuppressive agent from the at least one layer of an immunosuppresive agent; wherein the at least one layer of an immunosuppressive agent is adsorbed on or absorbed into the at least one coating layer; wherein the at least one coating layer has a thickness in a range from 50,000 to 500,000 Angstroms; wherein the at least one porous layer is composed of a polymer; wherein the at least one porous layer provides for a controlled release of the immunosuppressive agent through the at least one porous layer; and wherein the structure is configured as a vascular stent; the device further comprising at least one well formed in the at least one surface of the structure, the at least one well being a groove or slot in which the immunosuppressive agent of the at least one layer of an immunosuppressive agent is contained.
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Specification