METHODS FOR REDUCING NEOVASCULARIZATION OR EDEMA
First Claim
1. A biodegradable intraocular implant, comprising:
- a steroid; and
an auxiliary agent, wherein the steroid and the auxiliary agent are associated with a biodegradable polymer in the form of an intraocular implant.
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Accused Products
Abstract
Biocompatible intraocular implants include a steroid and an auxiliary agent, where the auxiliary agent is present in an amount sufficient to lessen the severity of at least one side effect compared to the use of an otherwise identical implant lacking said auxiliary agent. The steroid and the auxiliary agent may be present on the same intraocular implant or on different implants. The steroid and auxiliary agent may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants containing the steroid and an auxiliary agent may be placed in an eye to treat one or more ocular conditions while reducing the side effects otherwise accompanying steroid use.
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Citations
24 Claims
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1. A biodegradable intraocular implant, comprising:
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a steroid; and an auxiliary agent, wherein the steroid and the auxiliary agent are associated with a biodegradable polymer in the form of an intraocular implant. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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10. A biodegradable intraocular implant system, comprising:
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a steroid associated with a biodegradable polymer in the form of a first intraocular implant; and an auxiliary agent associated with a biodegradable polymer in the form of a second intraocular implant.
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11. A biodegradable intraocular implant system, comprising:
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a steroid associated with a biodegradable polymeric component in the form of an intraocular implant structured for intravitreal placement in an eye of an individual, the steroid being present in an amount effective in treating an ocular condition of the eye with a reduced toxicity relative to intravitreal injection of a liquid composition containing the same steroid; and an auxiliary agent associated with a biodegradable polymeric component in the form of an intraocular implant structured for intravitreal placement in an eye of an individual, the auxiliary agent being present in an amount effective to reduce the occurrence of at least one side effect present upon otherwise identical administration of the steroid alone. - View Dependent Claims (12, 13, 14, 15, 16, 22)
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17. A method of treating an ocular disease in an eye of a patient comprising
contacting an implant comprising a steroid with an ocular fluid in the eye of the patient; - thereby releasing steroid from the implant into the ocular fluid, and
contacting an implant comprising an auxiliary agent with the ocular fluid in the eye of the patient, thereby releasing auxiliary agent from the implant into the ocular fluid, wherein the steroid is present in an amount effective in treating the ocular disease, and wherein the auxiliary agent is present in an amount effective to reduce the occurrence of at least one side effect present upon otherwise identical administration of the steroid alone. - View Dependent Claims (18, 19, 20, 21, 23, 24)
- thereby releasing steroid from the implant into the ocular fluid, and
Specification