NANOPARTICLE DRUG FORMULATIONS
First Claim
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1. A composition comprising a suspension of nanoparticles in a liquid medium, wherein the suspended nanoparticles contain free base gacyclidine in an amount sufficient to achieve an effective concentration of free base gacyclidine in the suspension of at least 100 micromolar.
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Abstract
A suspension of nanoparticles in a liquid medium provides a mechanism for delivery of gacyclidine base or other drug that is substantially insoluble in the liquid medium.
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Citations
38 Claims
- 1. A composition comprising a suspension of nanoparticles in a liquid medium, wherein the suspended nanoparticles contain free base gacyclidine in an amount sufficient to achieve an effective concentration of free base gacyclidine in the suspension of at least 100 micromolar.
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24. A mixer comprising:
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a housing having first and second inlets and an outlet, the housing having one or more passages formed therein placing the first and second inlets and the outlet in fluid communication with one another; and a turbulence generator positioned in the one or more passages, the turbulence generator including a main member having a bore formed therein and an upper end, wherein the turbulence generator includes at least one fluid entrance formed in the upper end and a plurality of apertures formed along a length of the main member. - View Dependent Claims (25, 26, 27, 28, 29, 30)
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- 31. A composition comprising a nanoparticle powder, wherein the nanoparticles of the powder include free base gacyclidine, and wherein less than 10% (by weight) of all particles in the powder are larger than 200 nm.
Specification