Amino ceramide-like compounds and therapeutic methods of use
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Abstract
The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
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Citations
10 Claims
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1. (canceled)
- 2. A method for treating a patient with collagen vascular disease, comprising the step of administering to the patient a therapeutically effective amount of a composition comprising a compound of formula I:
- 4. A method for treating a patient with atherosclerosis, comprising the step of administering to the patient a therapeutically effective amount of a composition comprising a compound of formula I:
- 6. A method for treating a diabetic patient with renal hypertrophy, comprising the step of administering to the patient a therapeutically effective amount of a composition comprising a compound of formula I:
- 8. A method for treating patient having a microbial or viral infection, comprising the step of administering to the patient a therapeutically effective amount of a composition comprising a compound of formula I:
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