SIGNAL SENSING IN AN IMPLANTED APPARATUS WITH AN INTERNAL REFERENCE

• US 20080146894A1
• Filed: 12/19/2007
• Published: 06/19/2008
• Est. Priority Date: 12/19/2006
• Status: Abandoned Application

• Current Assignee: Kenergy, Inc.
• Original Assignee: Kenergy, Inc.
• Inventors: Denker, Stephen, Bulkes, Cherik
• Application Number:
  US11/959,952
• Publication Number:
  US 20080146894A1
• Time in Patent Office: Days
• US Class Current: 600/300
• CPC Class Codes: A61B 5/30 Input circuits therefor
• CPC Class Codes: A61B 5/308 for electrocardiography [ECG]
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61N 1/3704 Circuits specially adapted therefor, e.g. for sensitivity control

Abstract

An apparatus for sensing biological signals from an animal. The implanted apparatus includes at least one implantable electrode pair that is connected to a twisted pair of insulated conductors. The electrode pair is disposed at a first set of locations to sense biological signals. The twisted pair of insulated conductors is connected to an instrumentation amplifier via a passive network of filters. The amplifier amplifies the filtered biological signal from the electrode pair to provide an amplified differential signal. The amplifier has an internal voltage reference. Additionally, an energy source powers the apparatus without being connected to mains or an isolation transformer of medical equipment. A signal analysis module analyzes amplified differential signals to obtain at least one physiological parameter. The apparatus may also comprise a signal presentation module to display amplified signals and physiological parameters associated with the signal.

Claims

1. An apparatus for sensing biological signals from an animal, the apparatus comprising:

at least one set of electrodes that is configured to be implanted in the animal and disposed at a first set of locations to sense biological signals from the first set of locations;

a set of insulated conductors connected to the at least one set of electrodes, the set of insulated conductors formed in a configuration adapted to be substantially immune to electromagnetic interference,

a network of filters connected to the set of insulated conductors, the network of filters configured to filter the sensed biological signals;

an amplifier connected to the network of filters, the amplifier including an internal voltage reference and the amplifier configured to amplify the filtered biological signals to provide an amplified differential signal;

an energy source powering at least the amplifier, the energy source configured to be substantially free of an externally grounded energy supply external to the animal; and

a signal analysis module configured to receive the amplified differential signal and to analyze the amplified differential signal to determine at least one physiological parameter.

2. The apparatus of claim 1 further comprising at least one of a signal presentation module configured to display the amplified differential signal and a recording module to at least one of present and record the amplified differential signal.

3. The apparatus of claim 1, wherein the energy source is one of a battery, an infrared source, and a radiofrequency source.

4. The apparatus of claim 1, wherein the location of the at least one set of electrodes is one of intravascular, extravascular, and transvascular.

5. The apparatus of claim 1, wherein the at least one physiological parameter is a heart rate of the animal.

6. The apparatus of claim 1, wherein the internal reference is provided by a diode configured to produce a substantially constant voltage.

7. The apparatus of claim 6, wherein the diode is a light emitting diode.

8. The apparatus of claim 6, wherein the internal reference is substantially 1.2V.

9. The apparatus of claim 1, wherein the network of filters comprises at least one high pass filter and at least one low pass filter.

10. The apparatus of claim 9, wherein the at least one high pass filter is a single order filter.

11. The apparatus of claim 9, wherein each of the at least one high pass filter and the at least one low pass filter is a passive filter comprising at least one capacitor and at least one resistor.

12. The apparatus of claim 1, wherein the set of insulated conductors comprises a helical pair of insulated conductors.

13. The apparatus of claim 1, wherein the set of insulated conductors run in parallel and in close proximity of under 3 mm.

14. The apparatus of claim 1, wherein the set of insulated conductors comprises insulated conductors that are in a multifilar form, run in parallel, and have a helical formation.

15. The apparatus of claim 14, wherein the multifilar form is tuned by changing dimensions of at least one of conductor-to-helix diameter ratio, spacing, pitch, and spacing pattern.

16. The apparatus of claim 1, wherein the signal analysis module comprises at least one of a hysteresis based signal transition detector and a zero-crossing detector.

17. An apparatus for sensing biological signals from an animal, the apparatus comprising:

at least one implantable electrode pair disposed at intravascular locations to sense biological signals;

a twisted pair of insulated conductors connected to the at least one implantable electrode pair;

a passive network of filters connected to the twisted pair of insulated conductors, the passive network of filters configured to filter the sensed biological signals;

an instrumentation amplifier connected to the passive network of filters, the instrumentation amplifier configured to amplify the filtered biological signals to provide an amplified signal, wherein the amplifier has an internal voltage reference;

an energy source powering the apparatus without being connected to mains or an isolation transformer of medical equipment; and

a signal analysis module configured to analyze the amplified signal.

18. The apparatus of claim 17, wherein the internal voltage reference is generated by a diode.

19. The apparatus of claim 17, wherein the passive network of filters comprises a low pass filter, a high pass filter, and a noise filter.

20. An apparatus for sensing biological signals from an animal, the apparatus comprising:

at least one implantable electrode pair disposed at a first set of locations to sense biological signals;

a pair of insulated conductors connected to the at least one implanted electrode pair, the pair of insulated conductors configured to minimize sensitivity to electromagnetic interference;

a filter network connected to the pair of insulated conductors and configured to provide a filtered biological signal, the filter network comprising at least one high pass filter and at least one low pass filter, the high pass filter configured to provide AC coupling and the low pass filter configured to provide noise rejection;

an internal reference module configured to provide an internal voltage reference;

an instrumentation amplifier connected to the filter network, the instrumentation amplifier configured to receive the internal voltage reference and to amplify the filtered biological signal to provide an amplified biological signal;

an energy source powering the apparatus, the energy source configured to be substantially free of a wired connection to an energy supply external to the animal;

a signal analysis module configured to analyze the amplified differential signal to extract at least one physiological parameter;

wherein the implantable apparatus is substantially free of a wired ground connection to a ground external to the implantable apparatus.