METHOD OF SAMPLE CONTROL AND CALIBRATION ADJUSTMENT FOR USE WITH A NONINVASIVE ANALYZER
First Claim
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1. A noninvasive method for estimating a biological attribute concentration of human tissue of a tested subject, comprising the steps of:
- providing an apparatus for measuring light throughput, said apparatus comprising an energy source emitting light at multiple wavelengths, an input element, an output element, and a spectrum analyzer;
irradiating said tissue through said input element with multiple wavelengths of said light with resulting absorption of at least some of said wavelengths;
prior to said step of irradiating, using light sensitive elements in mechanically positioning along x- and/or y-axes said input element relative to a position of the human tissue, wherein said step of mechanically positioning aligns said input element to a targeted tissue volume;
collecting at least a portion of non-absorbed light with said output element;
determining the intensities of said collected light;
generating a model using calibration spectra and calibration reference concentrations;
adjusting said model with at least one direct reference measurement and a corresponding reference spectrum;
collecting at least one noninvasive prediction spectrum of said tissue of said tested subject;
estimating said biological attribute of said specific subject using said adjusted model; and
displaying said estimated biological attribute.
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Abstract
A method and apparatus for easing the use of an optically based noninvasive analyzer is presented. More particularly, a simplified algorithm is used that removes the daily requirement of collecting and using a noninvasive spectrum to update a calibration model. In another embodiment, a guide is used to substantially reduce variation in sample probe placement in relation to a skin tissue sampling site, resulting in the ability to maintain calibration performance with the use of a reference analyte concentration, with or without the use of a reference spectrum collected nearby in time.
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12 Claims
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1. A noninvasive method for estimating a biological attribute concentration of human tissue of a tested subject, comprising the steps of:
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providing an apparatus for measuring light throughput, said apparatus comprising an energy source emitting light at multiple wavelengths, an input element, an output element, and a spectrum analyzer; irradiating said tissue through said input element with multiple wavelengths of said light with resulting absorption of at least some of said wavelengths; prior to said step of irradiating, using light sensitive elements in mechanically positioning along x- and/or y-axes said input element relative to a position of the human tissue, wherein said step of mechanically positioning aligns said input element to a targeted tissue volume; collecting at least a portion of non-absorbed light with said output element;
determining the intensities of said collected light;generating a model using calibration spectra and calibration reference concentrations; adjusting said model with at least one direct reference measurement and a corresponding reference spectrum; collecting at least one noninvasive prediction spectrum of said tissue of said tested subject; estimating said biological attribute of said specific subject using said adjusted model; and displaying said estimated biological attribute. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification