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METHOD OF SAMPLE CONTROL AND CALIBRATION ADJUSTMENT FOR USE WITH A NONINVASIVE ANALYZER

  • US 20080146899A1
  • Filed: 02/07/2008
  • Published: 06/19/2008
  • Est. Priority Date: 08/14/1997
  • Status: Abandoned Application
First Claim
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1. A noninvasive method for estimating a biological attribute concentration of human tissue of a tested subject, comprising the steps of:

  • providing an apparatus for measuring light throughput, said apparatus comprising an energy source emitting light at multiple wavelengths, an input element, an output element, and a spectrum analyzer;

    irradiating said tissue through said input element with multiple wavelengths of said light with resulting absorption of at least some of said wavelengths;

    prior to said step of irradiating, using light sensitive elements in mechanically positioning along x- and/or y-axes said input element relative to a position of the human tissue, wherein said step of mechanically positioning aligns said input element to a targeted tissue volume;

    collecting at least a portion of non-absorbed light with said output element;

    determining the intensities of said collected light;

    generating a model using calibration spectra and calibration reference concentrations;

    adjusting said model with at least one direct reference measurement and a corresponding reference spectrum;

    collecting at least one noninvasive prediction spectrum of said tissue of said tested subject;

    estimating said biological attribute of said specific subject using said adjusted model; and

    displaying said estimated biological attribute.

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