Energy delivery systems and uses thereof

• US 20080147056A1
• Filed: 07/16/2007
• Published: 06/19/2008
• Est. Priority Date: 07/14/2006
• Status: Active Grant

• Current Assignee: Neuwave Medical, Inc. (Johnson & Johnson)
• Original Assignee: Micrablate, Inc.
• Inventors: van der Weide, Daniel Warren, Laeseke, Paul F., Brace, Christopher Lee, Lee, Fred T.
• Granted Patent: US 10,376,314 B2
• Time in Patent Office: Days
• US Class Current: 606/33
• CPC Class Codes: A61B 18/18 by applying electromagnetic radiation, e.g. microwaves radiation therapy A61N5/00
• CPC Class Codes: A61B 18/1815 using microwaves
• CPC Class Codes: A61B 2017/00274 Prostate operation, e.g. prostatectomy, turp, bhp treatment
• CPC Class Codes: A61B 2018/00005 Cooling or heating of the probe or tissue immediately surrounding the probe
• CPC Class Codes: A61B 2018/00023 closed, i.e. without wound contact by the fluid
• CPC Class Codes: A61B 2018/00351 Heart
• CPC Class Codes: A61B 2018/00404 Blood vessels other than those in or around the heart
• CPC Class Codes: A61B 2018/0044 Spinal cord
• CPC Class Codes: A61B 2018/00446 Brain
• CPC Class Codes: A61B 2018/00494 Stomach, intestines or bowel
• CPC Class Codes: A61B 2018/00511 Kidney
• CPC Class Codes: A61B 2018/00517 Urinary bladder or urethra
• CPC Class Codes: A61B 2018/00529 Liver
• CPC Class Codes: A61B 2018/00541 Lung or bronchi
• CPC Class Codes: A61B 2018/00547 Prostate
• CPC Class Codes: A61B 2018/00559 Female reproductive organs
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/00642 with feedback, i.e. closed loop control
• CPC Class Codes: A61B 2018/00702 Power or energy
• CPC Class Codes: A61B 2018/00714 Temperature
• CPC Class Codes: A61B 2018/00791 : Temperature
• CPC Class Codes: A61B 2018/00904 : Automatic detection of target tissue
• CPC Class Codes: A61B 2018/00982 : combined with or comprising means for visual or photographic inspections inside the body, e.g. endoscopes
• CPC Class Codes: A61B 2018/1823 : Generators therefor
• CPC Class Codes: A61B 2018/1861 : with an instrument inserted into a body lumen or cavity, e.g. a catheter
• CPC Class Codes: A61B 2090/374 : NMR or MRI
• CPC Class Codes: A61B 2090/376 : using X-rays, e.g. fluoroscopy
• CPC Class Codes: A61B 2090/3762 : using computed tomography systems [CT]
• CPC Class Codes: A61B 2090/378 : using ultrasound
• CPC Class Codes: A61B 90/37 : Surgical systems with images on a monitor during operation

Abstract

The present invention relates to comprehensive systems, devices and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, systems, devices, and methods are provided for treating a tissue region (e.g., a tumor) through application of energy.

Claims

1. A device comprising an antenna configured for delivery of energy to a tissue, said antenna having a cooling channel provided in an inner or outer conductor of a coaxial cable.

2. A device comprising an antenna configured for delivery of energy to a tissue, said antenna comprising an expandable material that changes volume in response to heat, wherein a change in volume alters energy delivery characteristics of the antenna.

3. The device of claim 2, wherein said antenna comprises a center-fed dipole and said expandable material is contained in said center-fed dipole.

4. A device comprising an antenna configured for delivery of energy to a tissue, said antenna comprising first and second chemicals that, when in contact with one another, create an endothermic reaction configured to cools said antenna.

5. The device of claim 4, wherein said first and second chemicals are separated from one another by a barrier.

6. The device of claim 5, wherein said barrier is configured to be removed in response to heat.

7. The device of claim 4, wherein said first and second chemicals are preloaded in said antenna prior to use.

8. The device of claim 4, wherein said first or second chemicals are supplied to said antenna during use.

9. A device comprising an antenna configured for delivery of energy to a tissue, said antenna comprising one or more cooling tubes inserted within a coaxial cable, said tubes configured to deliver coolant to said antenna.

10. The device of claim 9, wherein said one or more coolant tubes are between an outer conductor and dielectric material of said coaxial cable.

11. The device of claim 9, wherein said one or more coolant tubes are between an inner conductor and dielectric material of said coaxial cable.

12. The device of claim 9, wherein said one or more coolant tube are within an inner or outer conductor.

13. A device comprising an antenna configured for delivery of energy to a tissue, said antenna comprising two or more segments separated by a gap in an outer conductor of a coaxial cable, said gap filled with a resin.

14. The device of claim 13, wherein said resin comprises a curable epoxy resin.

15. A device comprising an antenna configured for delivery of energy to a tissue, wherein the antenna comprises a coaxial cable and wherein the antenna has a non-circular cross-sectional shape.

16. The device of claim 15, wherein said coaxial cable has a non-circular cross-sectional shape.

17. The device of claim 16, wherein a dielectric component of said coaxial cable has a non-circular shape.

18. A system comprising:

a) a power source component that provides an energy source and a coolant source;

b) a transport component for delivering energy and coolant from the power source component to a control hub; and

c) a portable control hub that receives energy and coolant from the transport component, said control hub positioned on a mobile arm, positionable above a patient workspace;

said control hub comprising;

i) a processor for regulating energy and coolant delivery to a plurality of energy delivery devices; and

ii) a plurality of connection ports for attachment of cables configured to delivery energy to energy delivery devices.

19. The system of claim 18, wherein said power source is located outside of a sterile field and said control hub is located within a sterile field.

20. The system of claim 18, wherein said power source supplies microwave energy.

21. The system of claim 18, wherein said power source supplies radio-frequency energy.

22. A system for monitoring and controlling ablation therapy, comprising:

a) one or more ablation devices configured for tissue ablation in a subject; and

b) a processor that runs an imaging and control program, said program comprising;

a component for monitoring the position of said one or more ablation devices;

a component for monitoring tissue status in the vicinity of said ablation devices; and

a component for reporting tissue status information to a medical practitioner.

23. The system of claim 22, wherein said one or more ablation devices comprise microwave energy delivery devices.

24. The system of claim 22, wherein said one or more ablation devices comprise radiofrequency energy delivery devices.

25. The system of claim 22, wherein said processor provides a component for displaying a representation of a tissue region.

26. The system of claim 25, wherein said processor further provides a component for permitting a user of the system to select a region on said displayed representation, of an area to be ablated.

27. The system of claim 26, wherein said processor further provides a component for automated treatment of said selected region.

28. The system of claim 27, wherein said automated treatment comprises energy delivery control.

29. The system of claim 27, wherein said automated treatment comprises monitoring tissue status at one or more time points.

30. The system of claim 29, wherein said monitoring tissue comprises monitoring location of a contrast agent in said tissue.

31. The system of claim 22, wherein said program components are provided by software run by said processor.