COATED IMPLANTABLE MEDICAL DEVICE
First Claim
1. A stent comprising:
- a generally thin walled cylinder, the cylinder having a plurality of arms, the arms being expandable and having a generally uniform thickness; and
at least one well formed in at least one of the arms, the well having a closed perimeter on all sides and an open top, and the well being smaller in all dimensions than the arm, the well containing a therapeutic agent applied therein and wherein the therapeutic agent is an immunosuppressive agent.
3 Assignments
0 Petitions
Accused Products
Abstract
A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
105 Citations
20 Claims
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1. A stent comprising:
a generally thin walled cylinder, the cylinder having a plurality of arms, the arms being expandable and having a generally uniform thickness; and
at least one well formed in at least one of the arms, the well having a closed perimeter on all sides and an open top, and the well being smaller in all dimensions than the arm, the well containing a therapeutic agent applied therein and wherein the therapeutic agent is an immunosuppressive agent.- View Dependent Claims (4, 8)
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2. A stent comprising:
a generally thin walled cylinder, the cylinder having a plurality of arms, the arms being expandable dependent on the amount of force applied to the arms, and the arms having a generally uniform thickness; and
at least one well formed in at least one of the arms, the well having a closed perimeter on all sides and an open top, and the well being smaller in all dimensions than the arm, the well containing a therapeutic agent applied therein;
wherein the well has a generally rectangular perimeter.
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3. In combination:
a stent comprising a generally thin walled cylinder, the cylinder having a plurality of arms, the arms being expandable dependent on the amount of force applied to the arms, and the arms having a generally uniform thickness; and
at least one well formed in at least one of the arms, the well having a closed perimeter on all sides and an open top, and the well being smaller in all dimensions than the arm, the well containing a therapeutic agent applied therein;
wherein the well has a generally rectangular perimeter; and
wherein the therapeutic agent is an immunosuppressive agent coated on the well.- View Dependent Claims (5, 9)
- 6. A stent comprising a generally thin walled structure having a plurality of arms, the arms expandable to assume the shape of a lumen into which the stent is emplaced, the arms having a thickness, and at least one well formed in at least one of the arms, the well having a closed perimeter on all sides and an open top, and the well being smaller in all dimensions than the arm, the well containing a therapeutic agent applied therein and wherein the therapeutic agent is an immunosuppressive agent.
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7. A stent comprising:
a generally thin walled cylinder, the cylinder having a plurality of generally solid arms, the arms being expandable dependent on the amount of force applied to the arms, and at least one well formed in at least one of the arms, the well having a closed perimeter on all sides and an open top, and the well being smaller in all dimensions than the arm, the well containing a reservoir of a therapeutic agent applied therein. - View Dependent Claims (11)
- 12. An expandable, self-expanding or expanded stent including a base material, wherein at least one well is formed in the base material of the stent, the at least one well containing a bioactive material applied therein.
Specification