ENDOPROSTHESIS WITH COATINGS

• US 20080147177A1
• Filed: 09/24/2007
• Published: 06/19/2008
• Est. Priority Date: 11/09/2006
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Inventors: Weber, Jan, Xu, Yixin, Scheuermann, Torsten
• Granted Patent: US 7,981,150 B2
• Time in Patent Office: Days
• US Class Current: 623/1.42
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 2400/12 Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
• CPC Class Codes: A61L 27/30 Inorganic materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 31/082 Inorganic materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence

Abstract

An endoprosthesis such as a coronary stent includes a polymeric reservoir of drug and an over coating formed of ceramic or metal for controlling elution of drag from the reservoir.

Claims

1. An endoprosthesis, comprising:

a first coating comprising a polymer, and

a second coating over the first coating formed of a porous ceramic or metal.

2. The endoprosthesis of claim 1, wherein the polymer includes a drug.

3. The endoprosthesis of claim 1, wherein the second coating is formed of a porous ceramic.

4. The endoprosthesis of claim 1, wherein the ceramic is IROX, TIOX, tantalum oxide, or niobium oxide.

5. The endoprosthesis of claim 1, wherein the first coating has a plurality of depressions.

6. The endoprosthesis of claim 1, wherein the second coating has pores with a pore diameter of about 1 nm to about 20 nm.

7. The endoprosthesis of claim 1, wherein the thickness of the second coating is about 10 to about 500 nm.

8. The endoprosthesis of claim 1, wherein the thickness of the first coating is about 0.1 to about 10 micron.

9. The endoprosthesis of claim 1, wherein the first coating contacts a surface of an endoprosthesis body.

10. The endoprosthesis of claim 9, wherein the endoprosthesis body is formed of a metal.

11. The endoprosthesis of claim 9, wherein the endoprosthesis body is formed of a polymer.

12. The endoprosthesis of claim 11, wherein the polymer is a biostable polymer.

13. The endoprosthesis of claim 11, wherein the polymer is a bioerodible polymer.

14. The endoprosthesis of claim 1, wherein the second coating is formed of porous metal.

15. The endoprosthesis of claim 14, wherein the porous metal is gold, ruthenium, titanium, tantalum, platinum, palladium, stainless steel or an alloy thereof.

16. The endoprosthesis of claim 1, wherein the ceramic has a smooth globular morphology to enhance endothelial cell growing over the ceramic.

17. A method of forming an endoprosthesis, comprising:

forming a polymer coating on the endoprosthesis wherein the polymer coating comprises a drug, and

forming a layer of porous ceramic or metal over the drag-containing polymer coating.

18. The method of claim 17, comprising forming the polymer coating sy spraying a solution of a polymer and a drag to a surface of an endoprosthesis body.

19. The method of claim 17, comprising introducing the drug by coating, dipping, or spraying in a solvent.

20. The method of claim 17, comprising forming the polymer coating by introducing a polymer by dipping, spraying, brushing, pressing, laminating, or PLD.

21. The method of claim 17 comprising introducing the drug by PLD.

22. The method of claim 17 comprising forming the layer by PLD.

23. The method of claim 17, further comprising forming depressions in the polymer coating by laser irradiation.

24. The method of claim 17, wherein the layer is ceramic.