Method of controlling dialysis using blood circulation times

• US 20080149563A1
• Filed: 12/22/2006
• Published: 06/26/2008
• Est. Priority Date: 12/22/2006
• Status: Abandoned Application

• Current Assignee: Renal Solutions, Inc. (Fresenius SE & Co. KGaA)
• Original Assignee: Renal Solutions, Inc. (Fresenius SE & Co. KGaA)
• Inventors: Ash, Stephen R.
• Application Number:
  US11/644,237
• Publication Number:
  US 20080149563A1
• Time in Patent Office: Days
• US Class Current: 210/646
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1611 Weight of the patient
• CPC Class Codes: A61M 1/341 by measuring the filtrate rate or volume
• CPC Class Codes: A61M 1/3431 upstream of the filter
• CPC Class Codes: A61M 1/3458 having electrolytes not present in the dialysate
• CPC Class Codes: A61M 1/3607 Regulation parameters
• CPC Class Codes: A61M 1/361 before treatment
• CPC Class Codes: A61M 1/3612 after treatment
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/3375 Acoustical, e.g. ultrasonic, measuring means
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient

Abstract

The instant method involves intermittently infusing saline boluses into a patient'"'"'s bloodstream during dialysis, and monitoring how long it takes for the bolus to complete a full circuit through the body. The concentrations versus time of one of more return flows as a result of the injected bolus are measured including a peak resulting from a fast circuit path, a peak resulting from a slow circuit path, and an average of the two aforementioned peaks. These parameters can be monitored over time in response to the injection of a plurality of boluses and their values over time used to determine the condition of the patient. Because of the rules governing abstracts, this abstract should not be used to construe the claims.

Claims

1. A method of controlling dialysis, comprising:

injecting a bolus into a blood stream during dialysis;

storing a time of injection of said bolus;

measuring a time of receipt of a return flow resulting from said injected bolus;

repeating said injecting, storing and measuring steps a plurality of times; and

determining a patient'"'"'s condition from said plurality of stored times of injection and measured times.

2. The method of claim 1 wherein said measuring a time of receipt of a return flow corresponds to measuring one of a maximum concentration or an average concentration.

3. The method of claim 1 wherein said measuring a time of receipt comprises measuring a time of receipt of a return flow from a fast flow circuit through the human body.

4. The method of claim 3 wherein said determining a patient '"'"'s condition comprises determining a difference between said stored time of injection and said measured time of receipt, and comparing said difference from one injected bolus to a next injected bolus.

5. The method of claim 4 wherein said patient is considered to be stable if said difference from one injected bolus to the next is constant, and said patient is considered to be approaching the patient'"'"'s dry weight if said difference from one injected bolus to the next is decreasing.

6. The method of claim 1 wherein said measuring a time of receipt comprises measuring a time of receipt of a particular concentration from a return flow from a slow flow circuit through the human body.

7. The method of claim 6 wherein said determining a patient '"'"'s condition comprises determining a difference between said stored time of injection and said measured time of receipt, and comparing said difference from one injected bolus to a next injected bolus.

8. The method of claim 7 wherein said patient is considered to be stable if said difference from one injected bolus to the next is constant, and said patient is considered to be approaching the patient'"'"'s dry weight if said difference from one injected bolus to the next is increasing.

9. The method of claim 1 wherein said measuring a time of receipt comprises measuring a time of receipt of a particular concentration of an average return flow from a slow flow circuit and from a fast flow circuit through the human body.

10. The method of claim 9 wherein said determining a patient '"'"'s condition comprises determining a difference between said stored time of injection and said measured time of receipt, and comparing said difference from one injected bolus to a next injected bolus.

11. The method of claim 10 wherein said patient is considered to be stable if said difference from one injected bolus to the next is constant, and said patient is considered to be approaching the patient'"'"'s dry weight if said difference from one injected bolus to the next is decreasing.

12. A method of controlling dialysis, comprising:

injecting a bolus into a blood stream during dialysis;

measuring a first time of receipt of a particular concentration of a first return flow resulting from said injected bolus;

measuring a second time of receipt of said particular concentration of a second return flow resulting from said injected bolus;

determining a time difference between said first and second times;

repeating said injecting, measuring a first time, measuring a second time, and determining a time difference a plurality of times; and

determining a patient'"'"'s condition from said plurality of time differences.

13. The method of claim 12 wherein said particular concentration corresponds to a maximum concentration.

14. The method of claim 12 wherein said determining comprises comparing said time differences.

15. The method of claim 14 wherein said patient is considered to be stable if said difference from one injected bolus to a next is constant, and said patient is considered to be approaching the patient'"'"'s dry weight if said difference from one injected bolus to a next is increasing.

16. A dialysis machine, comprising:

a first pump and a first plurality of valves for moving blood through a blood circuit;

a second pump for moving dialysate through a dialysate circuit; and

a control system comprising an input device for receiving information;

a non-volatile memory device responsive to said input device for storing patient specific information; and

a processor responsive to said memory device, said memory device carrying instructions which, when executed, cause the control system to execute a method comprising;

injecting a bolus into a blood stream during dialysis;

storing a time of injection of said bolus;

measuring a time of receipt of a particular concentration of a return flow resulting from said injected bolus;

repeating said injecting, storing and measuring steps a plurality of times; and

determining a patient'"'"'s condition from said plurality of stored times of injection and measured times.

17. The machine of claim 16 wherein said measuring a time of receipt comprises measuring a time of receipt of a particular concentration from a return flow from a fast flow circuit through the human body.

18. The machine of claim 17 wherein said determining a patient '"'"'s condition comprises determining a difference between said stored time of injection and said measured time of receipt, and comparing said difference from one injected bolus to a next injected bolus.

19. The machine of claim 18 wherein said patient is considered to be stable if said difference from one injected bolus to the next is constant, and said patient is considered to be approaching the patient'"'"'s dry weight if said difference from one injected bolus to the next is decreasing.

20. The machine of claim 16 wherein said measuring a time of receipt comprises measuring a time of receipt of a particular concentration from a return flow from a slow flow circuit through the human body.

21. The machine of claim 20 wherein said determining a patient '"'"'s condition comprises determining a difference between said stored time of injection and said measured time of receipt, and comparing said difference from one injected bolus to a next injected bolus.

22. The machine of claim 21 wherein said patient is considered to be stable if said difference from one injected bolus to the next is constant, and said patient is considered to be approaching the patient'"'"'s dry weight if said difference from one injected bolus to the next is increasing.

23. The machine of claim 16 wherein said measuring a time of receipt comprises measuring a time of receipt of a particular concentration of an average return flow from a slow flow circuit and from a fast flow circuit through the human body.

24. The machine of claim 23 wherein said determining a patient '"'"'s condition comprises determining a difference between said stored time of injection and said measured time of receipt, and comparing said difference from one injected bolus to a next injected bolus.

25. The machine of claim 24 wherein said patient is considered to be stable if said difference from one injected bolus to the next is constant, and said patient is considered to be approaching the patient'"'"'s dry weight if said difference from one injected bolus to the next is decreasing.

26. A computed readable storage medium carrying a set of instructions which, when executed, perform a method comprising:

injecting a bolus into a blood stream during dialysis;

storing a time of injection of said bolus;

measuring a time of receipt of a return flow resulting from said injected bolus;

repeating said injecting, storing and measuring steps a plurality of times; and

determining a patient'"'"'s condition from said plurality of stored times of injection and measured times.