Coatings and Solutions for Contact Lenses

• US 20080151181A1
• Filed: 10/23/2007
• Published: 06/26/2008
• Est. Priority Date: 12/20/2006
• Status: Abandoned Application

• Current Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Original Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Inventors: McGee, Joseph A., Vanderbilt, David P., Valint, Paul L.
• Application Number:
  US11/876,881
• Publication Number:
  US 20080151181A1
• Time in Patent Office: Days
• US Class Current: 351/160R
• CPC Class Codes: C09D 171/02 Polyalkylene oxides
• CPC Class Codes: G02B 1/043 Contact lenses

Abstract

A contact lens is coated with a layer of a polymer having affinity for mucin, such as a polymer with boronic acid moieties. This polymer is coated with a diol. While the contact lens is worn, the diol is replaced with mucin.

Claims

1. A contact lens having its surfaces coated with an inner layer and an outer layer, the inner layer comprising a polymer having affinity for mucin, and the outer layer comprising a diol.

2. The contact lens of claim 1, further comprising a layer intermediate the inner layer and the contact lens surface and containing an intermediate polymer different from the polymer having affinity for mucin.

3. The contact lens of claim 1, wherein the outer layer is removed from the inner layer while the contact lens is worn.

4. The contact lens of claim 1, wherein the polymer has greater affinity to mucin than does the diol.

5. The contact lens of claim 1, wherein the polymer has greater affinity to surfaces of the contact lens than does the diol.

6. The contact lens of claim 1, wherein the polymer comprises monomeric units derived from an ethylenically unsaturated monomer containing a boronic acid moiety.

7. The contact lens of claim 6, wherein the polymer comprises monomeric units derived from at least one member selected from the group consisting of:

a vinylphenyl boronic acid and a methacrylamido phenyl boronic acid.

8. The contact lens of claim 6, wherein the polymer further comprises monomeric units derived from an ethylenically unsaturated monomer containing a tertiary-amine moiety.

9. The contact lens of claim 6, wherein the polymer further comprises monomeric units derived from an ethylenically unsaturated monomer containing a moiety reactive with complementary reactive functionalities at the lens surface.

10. The contact lens of claim 6, wherein the polymer is a copolymer comprising:

monomeric units derived from an ethylenically unsaturated monomer containing a boronic acid moiety; and

monomeric units derived from an ethylenically unsaturated monomer containing a moiety reactive with complementary reactive functionalities at the lens surface.

11. The contact lens of claim 1, wherein the diol includes at least one member selected from the group consisting of:

glycerin, ethylene glycol, propylene glycol, sorbitol, manitol, monosaccarides, disaccharides and diol-terminated polymers.

12. The contact lens of claim 11, wherein the diol includes at least one diol-terminated polymer member selected from the group consisting of:

diol-terminated polyvinyl pyrrolidinone;

diol-terminated polyacrylamides;

diol-terminated polyethylene oxides; and

diol-terminated polyethylene oxide (PEO)/polypropylene oxide (PPO) block copolymers.

13. The contact lens of claim 1, wherein the polymer is covalently linked to the lens surface through primary amine or hydroxyl radicals at the lens surface.

14. The contact lens of claim 6, wherein upon removal of the diol during wear of the contact lens, the boronic acid moieties complex with mucin.

15. The contact lens of claim 1, wherein the polymer is permanently bound to the contact lens, and the diol is temporarily bound to the polymer.

16. A contact lens comprising a layer of a polymer comprising boronic acid moieties and a diol layer.

17. A contact lens packaged in a solution comprising a polymer having affinity for mucin and a diol.

18. The contact lens of claim 17, wherein the polymer comprises monomeric units derived from an ethylenically unsaturated monomer containing a boronic acid moiety.

19. The contact lens of claim 17, wherein the diol includes at least one member selected from the group consisting of:

glycerin, ethylene glycol, propylene glycol, sorbitol, manitol, monosaccarides, disaccharides and diol-terminated polymers.

20. A method comprising:

placing in a contact lens package a contact lens and a solution comprising a polymer having affinity for mucin and a diol;

sealing the package with lidstock; and

autoclaving the package and its contents.

21. The method of claim 20, wherein the polymer comprises monomeric units derived from an ethylenically unsaturated monomer containing a boronic acid moiety.

22. The method of claim 20, wherein the diol includes at least one member selected from the group consisting of:

glycerin, ethylene glycol, propylene glycol, sorbitol, manitol, monosaccarides, disaccharides and diol-terminated polymers.

23. The method of claim 22, where the polymer is linked to the contact lens surface and the diol is temporarily bound to the polymer.

24. The method of claim 22, wherein the diol is removed from the contact lens during wear, whereby mucin complexes with the polymer on the contact lens.