Substrates, systems and methods for analyzing materials
First Claim
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1. An analytical device, comprising:
- a substrate comprising a first surface and at least a first optical waveguide disposed upon the first surface; and
an analyte disposed sufficiently proximal to the first surface and external to the waveguide, to be illuminated by an evanescent field emanating from the waveguide when light is passed through the waveguide.
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Abstract
Substrates, systems and methods for analyzing materials that include waveguide arrays disposed upon or within the substrate such that evanescent fields emanating from the waveguides illuminate materials disposed upon or proximal to the surface of the substrate, permitting analysis of such materials. The substrates, systems and methods are used in a variety of analytical operations, including, inter alia, nucleic acid analysis, including hybridization and sequencing analyses, cellular analyses and other molecular analyses.
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Citations
37 Claims
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1. An analytical device, comprising:
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a substrate comprising a first surface and at least a first optical waveguide disposed upon the first surface; and an analyte disposed sufficiently proximal to the first surface and external to the waveguide, to be illuminated by an evanescent field emanating from the waveguide when light is passed through the waveguide. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 31)
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20. A method of illuminating an analyte, comprising:
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providing a substrate comprising a first surface and at least a first optical waveguide disposed upon the first surface; providing an analyte disposed sufficiently proximal to the first surface and external to the waveguide, to be illuminated by an evanescent field emanating from the waveguide when light is passed through the waveguide; and directing light through the first waveguide such that the evanescent field from the waveguide illuminates the analyte. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A system for analyzing an analyte, comprising:
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a substrate comprising a first surface and at least a first optical waveguide disposed upon the first surface; at least a first light source optically coupled to the at least first waveguide to direct light into the first waveguide; and an optical detection system positioned to receive and detect optical signals from an analyte disposed sufficiently proximal to the first surface and external to the waveguide to be illuminated by an evanescent field emanating from the waveguide when light from the light source is passed through the waveguide. - View Dependent Claims (32, 33, 34, 35, 36, 37)
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Specification