PACKAGING SOLUTIONS

• US 20080152540A1
• Filed: 12/22/2006
• Published: 06/26/2008
• Est. Priority Date: 12/22/2006
• Status: Abandoned Application

• Current Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Original Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Inventors: Kunzler, Jay F., Schorzman, Derek A., Blackwell, Richard I.
• Application Number:
  US11/615,217
• Publication Number:
  US 20080152540A1
• Time in Patent Office: Days
• US Class Current: 422/40
• CPC Class Codes: B65B 25/008 packaging of contact lenses

Abstract

The present invention is directed to new and improved packaging systems for storing cationic ophthalmic devices such as cationic contact lenses and to methods for packaging such cationic ophthalmic devices with solutions to improve the comfort of the lenses during wear. In particular, the present invention is directed to a packaging system for storing a cationic ophthalmic device in a solution comprising an effective amount of an anionic polymer. Such solutions are retained on the surface of an unused lens for extended periods of time, resulting in surface modification that persists in the eye, which may provide significant improvement in the wetting properties of fresh lenses used for the first time and, moreover, even several hours after lens insertion, preventing dryness and improving lubricity.

Claims

1. A method of preparing a package comprising a storable, sterile cationic ophthalmic device, the method comprising:

(a) immersing an ophthalmic device having at least one cationic surface in a solution comprising an effective amount of a soluble anionic polymer, wherein the solution has an osmolality of at least about 200 mOsm/kg and a pH in the range of about 6 to about 9;

(b) packaging the solution and the device in a manner preventing contamination of the lens by microorganisms; and

(c) sterilizing the packaged solution and device.

2. The method of claim 1, wherein the cationic ophthalmic device is a cationic ophthalmic lens.

3. The method of claim 1, wherein the cationic ophthalmic device is a cationic contact lens.

4. The method of claim 1, wherein the cationic ophthalmic device comprises a polymerization product of a monomeric mixture comprising one or more cationic silicone-containing monomers.

5. The method of claim 1, wherein the cationic ophthalmic device comprises a polymerization product of a monomeric mixture comprising one or more one or more cationic silicone-containing monomers and one or more hydrophilic monomers.

6. The method of claim 1, wherein the cationic ophthalmic device comprises a polymerization product of a monomeric mixture comprising one or more cationic silicon-containing monomers of formula I:

7. The method of claim 1, wherein the cationic ophthalmic device comprises a polymerization product of a monomeric mixture comprising one or more cationic silicon-containing monomers of formula II:

8. The method of claim 1, wherein the cationic ophthalmic device comprises a polymerization product of a monomeric mixture comprising one or more cationic silicon-containing monomers of formula VIII:

9. The method of claim 1, wherein the cationic ophthalmic device comprises a polymerization product of a monomeric mixture comprising one or more cationic silicon-containing monomers of formula XIV:

10. The method of claim 1, wherein the cationic ophthalmic device comprises a polymerization product of a monomeric mixture comprising one or more cationic random copolymers of formula XVI:

11. The method of claim 1, wherein the soluble anionic polymer in the solution is selected from the group consisting of an anionic cellulose-containing polymer, an anionic polymer derived from acrylic acid and esters thereof, an anionic polymer derived from methacrylic acid and esters thereof and mixtures thereof.

12. The method of claim 1, wherein the soluble anionic polymer in the solution is selected from the group consisting of polyacrylic acid, polymethacrylic acid, polyethylene amine, polysaccharide, hyaluronic acid, chondroitin sulfate and mixtures thereof.

13. The method of claim 1, wherein the soluble anionic polymer is present in the solution in an amount of about 0.05% w/v to about 5% w/v.

14. The method of claim 1, wherein the solution further comprises a buffering agent.

15. The method of claim 1, further comprising hermetically sealing the ophthalmic device and the packaging solution in the package.

16. The method of claim 15, wherein heat sterilization is performed subsequent to sealing of the package.

17. The method of claim 1, wherein the solution does not contain an effective disinfecting amount of a disinfecting agent.

18. The method of claim 1, wherein the solution does not contain a germicide compound.

19. A packaging system for the storage of a cationic ophthalmic device comprising a sealed container containing one or more unused cationic ophthalmic devices immersed in an aqueous packaging solution comprising an effective amount of a soluble anionic polymer, wherein the solution has an osmolality of at least about 200 mOsm/kg, a pH of about 6 to about 9 and is heat sterilized.

20. The system of claim 19, wherein the cationic ophthalmic device is a cationic ophthalmic lens.

21. The system of claim 19, wherein the cationic ophthalmic device is a cationic contact lens.

22. The system of claim 19, wherein the cationic ophthalmic device comprises a polymerization product of a monomeric mixture comprising one or more cationic silicone-containing monomers.

23. The system of claim 19, wherein the cationic ophthalmic device comprises a polymerization product of a monomeric mixture comprising one or more cationic silicon-containing monomers and one or more hydrophilic monomers.

24. The system of claim 19, wherein the cationic ophthalmic device comprises a polymerization product of a monomeric mixture comprising one or more cationic silicon-containing monomers of formula I:

25. The system of claim 19, wherein the cationic ophthalmic device comprises a polymerization product of a monomeric mixture comprising one or more cationic silicon-containing monomers of formula II:

26. The system of claim 19, wherein the cationic ophthalmic device comprises a polymerization product of a monomeric mixture comprising one or more cationic silicon-containing monomers of formula VIII:

27. The system of claim 19, wherein the cationic ophthalmic device comprises a polymerization product of a monomeric mixture comprising one or more cationic silicon-containing monomers of formula XIV:

28. The system of claim 19, wherein the cationic ophthalmic device comprises a polymerization product of a monomeric mixture comprising one or more cationic random copolymers of formula XVI:

29. The system of claim 19, wherein the soluble anionic polymer in the solution is selected from the group consisting of an anionic cellulose-containing polymer, an anionic polymer derived from acrylic acid and esters thereof, an anionic polymer derived from methacrylic acid and esters thereof and mixtures thereof.

30. The system of claim 19, wherein the soluble anionic polymer in the solution is selected from the group consisting of polyacrylic acid, polymethacrylic acid, polyethylene amine, polysaccharides, hyaluronic acid, chondroitin sulfate and mixtures thereof.

31. The system of claim 19, wherein the soluble anionic polymer is present in the solution in an amount of about 0.05% w/v to about 5% w/v.

32. The system of claim 19, wherein package is heat sterilized subsequent to sealing of the package.

33. The system of claim 19, wherein the solution does not contain an effective disinfecting amount of a disinfecting agent.

34. The system of claim 19, wherein the solution does not contain a germicide compound.