ENHANCED SAMPLE PROCESSING DEVICES, SYSTEMS AND METHODS
First Claim
Patent Images
1. A sample processing device comprising:
- a first chamber defining a first volume for containing sample material;
a second chamber defining a second volume for containing sample material and comprising a fluid;
a first channel fluidically connecting the first chamber and second chamber; and
a second channel in fluidic communication with the second chamber, wherein the second channel provides a path for the fluid to exit the second chamber when the sample material enters the second chamber; and
a valve located in the channel between the first chamber and the second chamber, wherein the valve comprises an impermeable membrane closing the first channel, and wherein the valve is opened by forming a void through the impermeable membrane using electromagnetic energy.
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Abstract
Devices, systems, and methods for processing sample materials. The sample materials may be located in a plurality of process chambers in the device, which is rotated during heating of the sample materials.
125 Citations
47 Claims
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1. A sample processing device comprising:
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a first chamber defining a first volume for containing sample material; a second chamber defining a second volume for containing sample material and comprising a fluid; a first channel fluidically connecting the first chamber and second chamber; and a second channel in fluidic communication with the second chamber, wherein the second channel provides a path for the fluid to exit the second chamber when the sample material enters the second chamber; and a valve located in the channel between the first chamber and the second chamber, wherein the valve comprises an impermeable membrane closing the first channel, and wherein the valve is opened by forming a void through the impermeable membrane using electromagnetic energy. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 16, 17, 18, 45, 46, 47)
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10. A sample processing device comprising:
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a first chamber defining a first volume; a second chamber defining a second volume and comprising a fluid; a first channel providing a downstream path from the first chamber to the second chamber; and a second channel providing an upstream path from the second chamber to a via; and a valve located in the channel between the first chamber and the second chamber, wherein the valve comprises an impermeable membrane closing the first channel, and wherein the valve is opened by forming a void through the impermeable membrane using electromagnetic energy.
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11. A sample processing device comprising:
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a substrate that comprises first and second major sides, the first major side of the substrate defining a via, and a first cover attached to the first major side of the substrate, wherein the first cover transmits electromagnetic energy of selected wavelengths; a plurality of process chamber arrays formed in the substrate, each process chamber array of the plurality of process chamber arrays comprising; a first chamber defining a volume for containing sample material; a second chamber defining a volume for containing sample material and comprising a first fluid; a first channel extending between the first chamber and second chamber; and a second channel in fluidic communication with the second chamber, the second channel being configured to provide a path for the fluid to exit the second chamber as the sample material enters the second chamber; wherein the plurality of process chamber arrays are arranged radially on the substrate such that the second chamber is located radially outward of the first chamber in each of the process chamber arrays; and a valve located in the channel between the first chamber and the second chamber in at least one process array of the plurality of process arrays, wherein the valve comprises an impermeable membrane closing the first channel, and wherein the valve is opened by forming a void through the impermeable membrane using electromagnetic energy passing through the first cover. - View Dependent Claims (12, 13, 14, 15, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A method comprising:
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opening a valve of a sample processing device by passing electromagnetic energy of selected wavelengths through a first cover of the sample processing device, wherein the electromagnetic energy of selected wavelengths forms a void through an impermeable membranes of the valve, the sample processing device further comprising; a first chamber defining a first volume for containing sample material; a second chamber defining a second volume for containing sample material; a first channel providing a downstream path from the first chamber to the second chamber, wherein the valve is located in the first channel between the first chamber and the second chamber; and a second channel providing an upstream path from the second chamber to a via; and rotating the sample processing device to pass a first fluid from the first chamber to the second chamber through the void in the impermeable membrane of the valve, wherein a second fluid passes into the via through the second channel as the first fluid passes into the second chamber. - View Dependent Claims (33, 34, 42, 43, 44)
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29. A method of controlling fluid flow through a sample processing device, the method comprising:
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providing a sample processing device comprising; a substrate that comprises first and second major sides and a first cover attached to the first major side of the substrate; a plurality of process chamber arrays formed in the substrate, each process chamber array of the plurality of process chamber arrays comprising; a first chamber defining a volume for containing sample material; a second chamber defining a volume for containing sample material and comprising a first fluid; a first channel extending between the first chamber and second chamber; a second channel in fluidic communication with the second chamber, the second channel being configured to provide a path for the first fluid to exit the second chamber when the sample material enters the second chamber; and a valve located in the first channel between the first chamber and the second chamber, wherein the valve comprises an impermeable membrane closing the first channel; opening the valves in one or more of the process chamber arrays of the plurality of process chamber arrays by passing electromagnetic energy of the selected wavelengths through the first cover, wherein the electromagnetic energy of selected wavelengths forms a void through the impermeable membranes of the valves in the one or more process chamber arrays; and rotating the sample processing device to pass a second fluid from the first chamber to the second chamber of one or more of the process chamber arrays through the voids in the impermeable membranes of the valves in the one or more process chamber arrays, wherein the first fluid is displaced from each second chamber as the second fluid passes into the second chamber. - View Dependent Claims (30, 31, 32, 35, 36)
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37. A method of moving sample material within a sample processing device, the method comprising:
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providing a device comprising a plurality of process chamber arrays, each process chamber array of the plurality of process chamber arrays comprising a first process chamber, a second process chamber, a valve located between the first process chamber and the second process chamber, the valve comprising an impermeable barrier, and a equilibrium channel in fluid communication with the second process chamber; and providing sample material in the first process chamber of the at least one process chamber array; placing the first process chamber of the at least one process chamber array in fluid communication with the second process chamber of the at least one process chamber array by forming a void in the impermeable barrier of the valve using electromagnetic energy of selected wavelengths through a cover attached to a surface of the device; and moving the sample material from the first process chamber of the at least one process chamber array to the second process chamber in the at least one process chamber array through the void by rotating the device, wherein air moves out of the second chamber in the at least one process chamber array through the respective equilibrium channel as the sample material is moved from the first process chamber to the second process chamber. - View Dependent Claims (38, 39, 40, 41)
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Specification