Corosolic Acid Formulation and Its Application for Weight-Loss Management and Blood Sugar Balance

• US 20080152705A1
• Filed: 09/06/2006
• Published: 06/26/2008
• Est. Priority Date: 04/05/2000
• Status: Active Grant

• Current Assignee: Soft Gel Technologies Incorporated (Kenko Corpo)
• Original Assignee: Soft Gel Technologies Incorporated (Kenko Corpo)
• Inventors: Udell, Ronald G., Hari, Siva P.
• Granted Patent: US 7,989,005 B2
• Time in Patent Office: Days
• US Class Current: 424/456
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 47/44 Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14
• CPC Class Codes: A61K 9/4825 Proteins, e.g. gelatin gelatin capsule shells with substantial amounts of other macromolecular substances A61K9/4816
• CPC Class Codes: A61K 9/485 Inorganic compounds
• CPC Class Codes: A61K 9/4858 Organic compounds

Abstract

A soft gelatin capsule and method to deliver an efficable dose of Lagerstroemia speciosa L. (marketed by Soft Gel Technologies under the trademark Glucosol™) for the assistance and maintenance of moderate weight loss through blood sugar maintenance. The product relies on the effects of corosolic acid on blood sugar levels to derive a healthy weight loss effect for Type II diabetics (non-insulin dependent) and healthy non-diabetics and the improved absorption of an oil based delivery system. The product provides safe and sustainable weight loss when combined with a restricted calorie diet and regular exercise. Its benefits include improvement of cardiovascular health, normalized blood sugar levels, and improved physical appearance with the positive psychological effects associated with successful and safe weight loss/maintenance.

Claims

1. A method for manufacture of a soft gel capsule containing corosolic acid comprising the steps of:

heating rice brain oil;

adding a filler to the heated rice bran oil;

adding corosolic acid to the heated rice bran oil and filler to form a mixture;

cooling the mixture to room temperature; and

encapsulating the mixture into a soft gel capsule.

2. The method of claim 1, wherein the corosolic acid is added under reduced pressure.

3. The method of claim 1, further including the step of blanketing the cooled mixture with nitrogen.

4. The method of claim 2, further including the step of blanketing the cooled mixture with nitrogen.

5. The method of claim 1, wherein the filler is yellow bees wax.

6. The method of claim 5, wherein the corosolic acid is added under reduced pressure.

7. The method of claim 5, further including the step of blanketing the cooled mixture with nitrogen.

8. The method of claim 6, further including the step of blanketing the cooled mixture with nitrogen.

9. The method of claim 1, wherein the filler is silica.

10. The method of claim 9, wherein the corosolic acid is added under reduced pressure.

11. The method of claim 9, further including the step of blanketing the cooled mixture with nitrogen.

12. The method of claim 10, further including the step of blanketing the cooled mixture with nitrogen.

13. The method of claim 1, wherein the rice bran oil is heated to about 35°

C.

14. The method of claim 13, wherein the corosolic acid is added under reduced pressure.

15. The method of claim 13, further including the step of blanketing the cooled mixture with nitrogen.

16. The method of claim 14, further including the step of blanketing the cooled mixture with nitrogen.

17. The method of claim 13, wherein the filler is yellow bees wax.

18. The method of claim 17, wherein the corosolic acid is added under reduced pressure.

19. The method of claim 17, further including the step of blanketing the cooled mixture with nitrogen.

20. The method of claim 18, further including the step of blanketing the cooled mixture with nitrogen.

21. The method of claim 13, wherein the filler is silica.

22. The method of claim 21, wherein the corosolic acid is added under reduced pressure.

23. The method of claim 21, further including the step of blanketing the cooled mixture with nitrogen.

24. The method of claim 22, further including the step of blanketing the cooled mixture with nitrogen.