Analysis unit, biosensor and method for detecting or determining the concentration of an analyte
First Claim
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1. An analysis unit for at least one of detecting and determining the concentration of an analyte, the analysis unit comprising:
- at least one sensor with a quartz oscillator, on whose surface capture molecules which bind specifically to the analyte are immobilized, a natural frequency of the quartz oscillator depending on at least one of whether and how many analyte molecules are bound to the capture molecules; and
a transponder for wireless information interchange with a reader device, electrically connected to the quartz oscillator and designed to transmit information to the reader device, regarding at least one of whether and how many analyte molecules have bound to the capture molecules, the at least one sensor including three quartz oscillators, the first quartz oscillator being coated with first control molecules whose molecular weight corresponds to that of the capture molecules, the second quartz oscillator being coated with second control molecules whose molecular weight corresponds to a complex of a capture molecule and an analyte molecule, and the third quartz oscillator being coated with capture molecules.
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Abstract
A biosensor includes an analysis unit and a reader device for detecting an analyte. In at least one embodiment, the analysis unit includes a quartz oscillator on whose surface capture molecules, which bind specifically to the analyte, are immobilized; as well as a transponder to transmit information, regarding whether and/or how many analyte molecules have bound to the capture molecules, to the reader device.
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Citations
23 Claims
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1. An analysis unit for at least one of detecting and determining the concentration of an analyte, the analysis unit comprising:
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at least one sensor with a quartz oscillator, on whose surface capture molecules which bind specifically to the analyte are immobilized, a natural frequency of the quartz oscillator depending on at least one of whether and how many analyte molecules are bound to the capture molecules; and a transponder for wireless information interchange with a reader device, electrically connected to the quartz oscillator and designed to transmit information to the reader device, regarding at least one of whether and how many analyte molecules have bound to the capture molecules, the at least one sensor including three quartz oscillators, the first quartz oscillator being coated with first control molecules whose molecular weight corresponds to that of the capture molecules, the second quartz oscillator being coated with second control molecules whose molecular weight corresponds to a complex of a capture molecule and an analyte molecule, and the third quartz oscillator being coated with capture molecules. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 13, 14, 15, 16, 17, 18, 19, 22, 23)
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12. A method for at least one of detecting and determining the concentration of an analyte using a biosensor, the method comprising:
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bringing quartz oscillators, of an analysis unit of the biosensor, in contact with a sample to be examined; activating a transponder of the analysis unit via an electromagnetic field generated by a reader device, and exciting the quartz oscillators to oscillate; determining at least one of impedances and natural frequencies of the quartz oscillators; and transmitting information regarding at least one of the impedances and the natural frequencies of the quartz oscillators to the reader device. - View Dependent Claims (20, 21)
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Specification