Skin Rejuvenation Cream

• US 20080153757A1
• Filed: 12/17/2007
• Published: 06/26/2008
• Est. Priority Date: 12/26/2006
• Status: Active Grant

• Current Assignee: AD Lunam Labs, Inc.
• Original Assignee: AD Lunam Labs, Inc.
• Inventors: Beeson, William H., Rockhill, Alvin T.
• Granted Patent: US 8,691,247 B2
• Time in Patent Office: Days
• US Class Current: 514/17
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/355 Tocopherols, e.g. vitamin E
• CPC Class Codes: A61K 31/375 Ascorbic acid, i.e. vitamin C; Salts thereof
• CPC Class Codes: A61K 36/55 Linaceae (Flax family), e.g. Linum
• CPC Class Codes: A61K 38/08 Peptides having 5 to 11 amino acids A61K38/043 - A61K38/046 take precedence
• CPC Class Codes: A61K 38/095 Oxytocins; Vasopressins; Related peptides
• CPC Class Codes: A61K 47/12 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 47/46 Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
• CPC Class Codes: A61K 8/27 Zinc; Compounds thereof
• CPC Class Codes: A61K 8/368 with carboxyl groups directly bound to carbon atoms of aromatic rings
• CPC Class Codes: A61K 8/37 Esters of carboxylic acids
• CPC Class Codes: A61K 8/44 Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• CPC Class Codes: A61K 8/498 having 6-membered rings or their condensed derivatives, e.g. coumarin
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61K 8/676 Ascorbic acid, i.e. vitamin C
• CPC Class Codes: A61K 8/678 Tocopherol, i.e. vitamin E
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

The subject invention relates to a skin cream that can be used to moisturize and rejuvenate skin that has been damaged by exposure to sunlight or which has simply been affected over the years by intrinsic aging. It can also be used to slow the rate of photo-induced aging to maintain beautiful skin tone and texture over the years. It inhibits the formation of wrinkles and in some cases reduces the depth of existing wrinkles or eliminates them entirely. In some cases, the skin cream of this invention also lightens age spots and other types of blemishes associated with aging. This invention is based upon the discovery that alkyl lactates, such as ethyl lactate, can be used to improve the penetration of active ingredients in skin care formulations deep into lower layers of the skin tissue. For instance, ethyl lactate can be included in aqueous based skin creams, such as oil in water emulsions, to deliver active ingredients deep into the skin structure. Ethyl lactate is particularly desirable for utilization in conjunction with ascorbic acid (Vitamin C) containing skin cream formulations. This is beneficial because the overall effectiveness of skin creams that utilize ascorbic acid as an active ingredient is contingent upon delivery of the ascorbic acid through the outer layers of the stratum corneum and viable epidermis and into the dermis layer of the skin structure. The present invention more specifically discloses a topical formulation comprising about 1 weight percent to about 20 weight percent ascorbic acid, about 1 weight percent to about 10 weight percent of an amino acid selected from the group consisting of phenylalanine and tyrosine, about 0.5 weight percent to about 5 weight percent of a non-toxic zinc salt, about 0.01 weight percent to about 20 weight percent of an alkyl lactate, wherein the alkyl group in the alkyl lactate contains from 2 to about 12 carbon atoms, and a pharmaceutically acceptable carrier.

Claims

1. A topical formulation comprising about 1 weight percent to about 20 weight percent ascorbic acid, about 1 weight percent to about 10 weight percent of an amino acid selected from the group consisting of phenylalanine and tyrosine, about 0.5 weight percent to about 5 weight percent of a non-toxic zinc salt, about 0.01 weight percent to about 20 weight percent of at least one alkyl lactate, wherein the alkyl group in the alkyl lactate contains from 2 to about 12 carbon atoms, and a pharmaceutically acceptable carrier.

2. A topical formulation as specified in claim 1 wherein the alkyl lactate is ethyl lactate.

3. A topical formulation as specified in claim 1 wherein the alkyl lactate is isoamyl lactate.

4. A topical formulation as specified in claim 1 wherein the alkyl lactate is a mixture of ethyl lactate and isoamyl lactate, wherein the weight ratio of ethyl lactate to isoamyl lactate is within the range of about 1:

10 to about 20;

1.

5. A topical formulation as specified in claim 1 wherein the alkyl lactate is a mixture of ethyl lactate and isoamyl lactate, wherein the mixture of ethyl lactate to isoamyl lactate contains from about 30 weight percent to about 70 weight percent ethyl lactate and from about 30 weight percent to about 70 weight percent isoamyl lactate.

6. A topical formulation as specified in claim 1 wherein the alkyl lactate is a mixture of ethyl lactate and isoamyl lactate, wherein the mixture of ethyl lactate to isoamyl lactate contains from about 40 weight percent to about 60 weight percent ethyl lactate and from about 40 weight percent to about 60 weight percent isoamyl lactate.

7. A topical formulation as specified in claim 1 wherein the topical formulation is further comprised of about 1 weight percent to about 30 weight percent α

-tocopherol.

8. A topical formulation as specified in claim 7 wherein the α

-tocopherol is present at a level which is within the range of about 2 weight percent to about 8 weight percent.

9. A topical formulation as specified in claim 7 wherein the α

-tocopherol is present at a level which is within the range of about 3 weight percent to about 5 weight percent.

10. A topical formulation as specified in claim 1 wherein the topical formulation is further comprised of idebenone.

11. A topical formulation as specified in claim 10 wherein the idebenone is present at a level which is within the range of about 0.01 weight percent to about 5 weight percent.

12. A topical formulation as specified in claim 1 wherein the topical formulation is further comprised of carnosic acid.

13. A topical formulation as specified in claim 12 wherein the carnosic acid is present at a level which is within the range of about 0.01 weight percent to about 1.5 weight percent.

14. A topical formulation as specified in claim 1 which is further comprised of palmitoyl pentapeptide.

15. A topical formulation as specified in claim 1 wherein the amino acid is phenylalananene.

16. A topical formulation as specified in claim 1 wherein the alkyl lactate is present at a level which is within the range of about 0.2 weight percent to about 1 weight percent.

17. A topical formulation as specified in claim 1 wherein the alkyl lactate is present at a level which is within the range of about 0.2 weight percent to about 0.5 weight percent.

18. A method of rejuvenating human skin affected by intrinsic aging and/or photo-induced aging, said method comprising topically applying the topical formulation of claim 1 to the skin.

19. A topical formulation comprising about 0.01 weight percent to about 5 weight percent carnosic acid, about 0.01 weight percent to about 20 weight percent of at least one alkyl lactate, wherein the alkyl group in the alkyl lactate contains from 2 to about 12 carbon atoms, and a pharmaceutically acceptable carrier.

20. A topical formulation comprising (1) about 0.01 weight percent to about 2 weight percent of at least one polyphenolic antioxidant selected from the group consisting of condensed proanthocyanidins, chlorogenic acid, quinic acid, and ferulic acid, (2) about 0.01 weight percent to about 20 weight percent of at least one alkyl lactate, wherein the alkyl group in the alkyl lactate contains from 2 to about 12 carbon atoms, and (3) a pharmaceutically acceptable carrier.