Endoscopic System for In-Vivo Procedures

• US 20080154090A1
• Filed: 01/04/2006
• Published: 06/26/2008
• Est. Priority Date: 01/04/2005
• Status: Abandoned Application

• Current Assignee: Dune Medical Devices Ltd. (Dilon Technologies LLC)
• Original Assignee: Dune Medical Devices Ltd. (Dilon Technologies LLC)
• Inventors: Hashimshony, Dan
• Application Number:
  US10/567,581
• Publication Number:
  US 20080154090A1
• Time in Patent Office: Days
• US Class Current: 600/104
• CPC Class Codes: A61B 1/018 for receiving instruments

Abstract

An endoscopic system for in-vivo tissue characterization, using a nonirradiative electromagnetic sensor, is described. The endoscopic system is further configured to employ several follow-up procedures, for example, biopsy sampling, localized surgery, dispensing a medicament, and the like, so that on the whole, the endoscopic system provides for the early detection of cancerous and pre-cancerous tissue, in vivo, and for the application of immediate follow-up procedures to any such tissue.

Claims

1. An endoscope, which comprises:

an intracorporeal portions, configured for insertion into a body, and including;

an electromagnetic sensor for tissue characterizations, operative in an electromagnetic frequency range of less than 100 Ghz;

a communication line, on which the electromagnetic sensor is mounted; and

an extracorporeal portion, configured for manipulating the intracorporeal portion.

2. The endoscope of claim 1, wherein the communication line is formed as an instrument bundle.

3. The endoscope of claim 2, wherein the instrument bundle extends beyond a distal-most end of the endoscope, with respect to an operator, and a distal-most end of the instrument bundle may be manipulated, extracorporeally, to bring the electromagnetic sensor to contact with a tissue, for characterization.

4. The endoscope of claim 1, wherein the intracorporeal portion further includes an instrument channel, and wherein the electromagnetic sensor for tissue characterization is inserted into the instrument channel.

5. The endoscope of claim 4, wherein the electromagnetic sensor for tissue characterization may be removed from the instrument channel and replaced with another instrument.

6. The endoscope of claim 4, and further including a catheter, wherein the electromagnetic sensor is inserted into the catheter, and the catheter is inserted into the instrument channel.

7. The endoscope of claim 6, wherein the catheter extends beyond a distal-most end of the endoscope, with respect to an operator, and a distal-most end of the catheter may be manipulated independently of the distal-most end of the endoscope.

8. The endoscope of claim 1, wherein the intracorporeal portion further includes an optical channel for an optical instrument.

9. The endoscope of claim 1, wherein the optical instrument is configured to observe the electromagnetic sensor.

10. The endoscope of claim 1, wherein the intracorporeal portion further includes a second instrument.

11. The endoscope of claim 10, wherein the second instrument is selected from the group consisting of an optical sensor, an X-ray sensor, an RF sensor, a MW sensor, an infrared thermography sensor, or an ultrasound sensor, an MR sensor, an impedance sensor, a temperature sensor, a biosensor, a chemical sensor, a radioactive-emission sensor, and a mechanical sensor.

12. The endoscope of claim 10, wherein the second instrument is configured to sense the electromagnetic sensor.

13. The endoscope of claim 1, wherein the intracorporeal portion is designed for motion in a body lumen.

14. The endoscope of claim 13, wherein the intracorporeal portion is designed for reaching the lumen by percutaneous insertion.

15. The endoscope of claim 13, configured for characterizing a tissue along the lumen wall.

16. The endoscope of claim 13, configured for characterizing a tissue outside the lumen, by penetrating the lumen wall.

17. The endoscope of claim 13, wherein the body lumen is selected from the group consisting of an oral cavity, a nostril, an esophagus, a gastrointestinal tract, a rectum, a colon, bronchi, a vagina, a cervix, a urinary tract, a bladder, a uterus, and a blood vessel.

18. The endoscope of claim 1, wherein the intracorporeal portion is designed for insertion through a trocar valve.

19. The endoscope of claim 1, wherein tissue characterization relates to the detection of a malignancy.

20. The endoscope of claim 1, wherein tissue characterization relates to the detection of a pre-cancerous state.

72. The endoscope of claim 10, wherein the second instrument is configured for taking a biopsy sample.

73. The endoscope of claim 10, wherein the second instrument is configured for localized surgery.

74. The endoscope of claim 10, wherein the second instrument is configured for dispensing medication.

75. The endoscope of claim 13, wherein the intracorporeal portion includes a cutting tool, configured to facilitate entry to the body lumen by percutaneous insertion.

76. The endoscope of claim 13, wherein the intracorporeal portion includes a cutting tool configured for penetrating the wall of the body lumen, for interacting with a tissue outside the body lumen.

77. The endoscope of claim 1, wherein the electromagnetic sensor further includes a cutting tool, thus forming an integrated sensing-cutting device.

78. The endoscope of claim 1, wherein the electromagnetic sensor is a nonirradiative electromagnetic sensor.

79. The endoscope of claim 78, wherein the nonirradiative electromagnetic sensor is configured for:

applying an electrical pulse to the tissue;

generating an electrical fringe field in a near-field zone of the tissue, so as to produce a reflected pulse from the near-field zone of the tissue with negligible radiation penetrating the tissue; and

detecting the reflected electrical pulse.

80. The endoscope of claim 78, wherein the nonirradiative electromagnetic sensor includes:

a resonating element, formed as a conductive structure, configured to be placed proximally to an edge of the tissue, without penetrating the tissue, and having a diameter-equivalent D, which defines a cross-sectional area of the resonating element, on a plane substantially parallel with the edge of the tissue; and

at least one conductive lead, for providing communication with an external system,

wherein the resonating element is configured to resonate at a free-air wavelength range of between about λ and

about 10λ

, wherein λ

is at least about ten times the diameter-equivalent D, and wherein upon receiving a signal in the range of between about λ and

about 10λ

, the electromagnetic sensor is configured to induce electric and magnetic fields, in a near zone, in the tissue, the near zone being a hemisphere having a diameter of substantially D, beginning with the edge of the tissue, while causing negligible radiation in a far zone, so that the tissue, in the near zone, effectively functions as part of the resonating element,

and wherein different tissue types have different resonating responses to the electromagnetic sensor, so that the tissue, in the near zone, may be categorized, by the resonating response to the nonirradiative electromagnetic sensor.

81. The endoscope of claim 1, wherein the electromagnetic sensor is operative in an electromagnetic frequency range of less than 10 Ghz.

90. The endoscope of claim 7, wherein the distal-most end of the catheter is manipulated electronically.

91. The endoscope of claim 7, wherein the distal-most end of the catheter is manipulated manually.

21. A method of tissue characterization, which comprises:

providing an endoscope, comprising;

an intracorporeal portions, configured for insertion into a body, and including;

an electromagnetic sensor for tissue characterization, operative in an electromagnetic frequency range of less than 100 Ghz.

a communication line, on which the electromagnetic sensor is mounted; and

an extracorporeal portion, configured for manipulating the intracorporeal portion;

inserting the electromagnetic sensor intracorporeally; and

characterizing an intracoroporeal tissue.

22. The method of claim 21, wherein the electromagnetic sensor is mounted on an instrument bundle.

23. The method of claim 22, wherein the instrument bundle extends beyond a distal-most end of the endoscope, with respect to an operator, and further including manipulating a distal-most end of the instrument bundle, extracorporeally, to bring the electromagnetic sensor to contact with a tissue, for characterization.

24. The method of claim 21, wherein the electromagnetic sensor for tissue characterization moves within an instrument channel.

25. The method of claim 24, and further including:

after the characterizing the intracoroporeal tissue, removing the electromagnetic sensor for tissue characterization from the instrument channel;

inserting a second instrument to the instrument channel; and

performing a second procedure with the second instrument.

26. The method of claim 25, wherein the second procedure includes taking a biopsy sample.

27. The method of claim 25, wherein the second procedure includes a localized surgery.

28. The method of claim 25, wherein the second procedure includes dispensing medication.

29. The method of claim 25, wherein the second procedure includes characterizing the tissue by an additional sensor.

30. The method of claim 24, wherein the electromagnetic sensor for tissue characterization moves within a catheter, inserted into the instrument channel.

31. The method of claim 30, and further including manipulating a distal-most end of the catheter, extracorporeally, to bring the electromagnetic sensor to contact with a tissue, for characterization.

32. The method of claim 21, and further including inserting an optical instrument to visually observe the electromagnetic sensor as it makes contact with a tissue.

33. The method of claim 21, and further including inserting a second instrument for characterizing the tissue by a second modality, together with the electromagnetic sensor.

34. The method of claim 33, wherein the second instrument is selected from the group consisting of an optical sensor, an X-ray sensor, an RF sensor, a MW sensor, an infrared thermography sensor, or an ultrasound sensor, an MR sensor, an impedance sensor, a temperature sensor, a biosensor, a chemical sensor, a radioactive-emission sensor, and a mechanical sensor.

35. The method of claim 33, wherein the second instrument is configured to sense the electromagnetic sensor.

36. The method of claim 21, wherein the inserting includes:

inserting to a body lumen from a body orifice; and

characterizing a tissue along the body lumen.

37. The method of claim 21, wherein the inserting includes:

inserting to a body lumen from a body orifice;

penetrating the body lumen; and

characterizing a tissue beyond the body lumen.

38. The method of claim 21, wherein the inserting includes:

percutaneously inserting;

reaching a body lumen;

moving along the body lumen; and

characterizing a tissue along the body lumen.

39. The method of claim 21, wherein the inserting includes:

percutaneously inserting;

reaching a body lumen;

moving along the body lumen;

penetrating the body lumen; and

characterizing a tissue beyond the body lumen.

40. The method of claim 21, wherein the body lumen is selected from the group consisting of an oral cavity, a nostril, an esophagus, a gastrointestinal tract, a rectum, a colon, bronchi, a vagina, a cervix, a urinary tract, a bladder, a uterus, and a blood vessel.

41. The method of claim 21, wherein inserting includes inserting through a trocar valve.

42. The method of claim 21, wherein tissue characterization relates to the detection of a malignancy.

43. The method of claim 21, wherein tissue characterization relates to the detection of a pre-cancerous state.

82. The method of claim 21, wherein the electromagnetic sensor is a nonirradiative electromagnetic sensor.

83. The method of claim 82, wherein the nonirradiative electromagnetic sensor is configured for:

applying an electrical pulse to the tissue;

generating an electrical fringe field in a near-field zone of the tissue, so as to produce a reflected pulse from the near-field zone of the tissue with negligible radiation penetrating the tissue; and

detecting the reflected electrical pulse.

84. The method of claim 82, wherein the nonirradiative electromagnetic sensor includes:

a resonating element, formed as a conductive structure, configured to be placed proximally to an edge of the tissue, without penetrating the tissue, and having a diameter-equivalent D, which defines a cross-sectional area of the resonating element, on a plane substantially parallel with the edge of the tissue; and

at least one conductive lead, for providing communication with an external system,

wherein the resonating element is configured to resonate at a free-air wavelength range of between about λ and

about 10λ

, wherein λ

is at least about ten times the diameter-equivalent D, and wherein upon receiving a signal in the range of between about λ and

about 10λ

, the electromagnetic sensor is configured to induce electric and magnetic fields, in a near zone, in the tissue, the near zone being a hemisphere having a diameter of substantially D, beginning with the edge of the tissue, while causing negligible radiation in a far zone, so that the tissue, in the near zone, effectively functions as part of the resonating element,

and wherein different tissue types have different resonating responses to the electromagnetic sensor, so that the tissue, in the near zone, may be categorized, by the resonating response to the nonirradiative electromagnetic sensor.

85. The method of claim 21, wherein the electromagnetic sensor is operative in an electromagnetic frequency range of less than 10 Ghz.

86. The method of claim 24, and further including a catheter, wherein the electromagnetic sensor is inserted into the catheter, and the catheter is inserted into the instrument channel.

87. The method of claim 86, wherein the catheter extends beyond a distal-most end of the endoscope, with respect to an operator, and a distal-most end of the catheter may be manipulated independently of the distal-most end of the endoscope.

88. The method of claim 86, wherein the distal-most end of the catheter is manipulated electronically.

89. The method of claim 86, wherein the distal-most end of the catheter is manipulated manually.

44. An in-vivo method, comprising:

providing an endoscope, having an instrument channel;

inserting into the instrument channel an electromagnetic sensor for tissue characterization, operative in an electromagnetic frequency range of less than 100 Ghz and mounted on communication line;

characterizing a tissue;

removing the sensor for tissue characterization;

inserting a second instrument into the instrument channel, to the location of the characterized tissue; and

performing a second procedure with the second instrument.

45. The method of claim 44, wherein the electromagnetic sensor for tissue characterization is a nonirradiative electromagnetic sensor.

46. The method of claim 50, wherein the additional sensor is selected from the group consisting of an optical sensor, an x-ray sensor, an RF sensor, a MW sensor, an infrared thermography sensor, or an ultrasound sensor, an MR sensor, an impedance sensor, a temperature sensor, a biosensor, a chemical sensor, a radioactive-emission sensor, and a mechanical sensor.

47. The method of claim 44, wherein the second procedure includes taking a biopsy sample.

48. The method of claim 44, wherein the second procedure includes a localized surgery.

49. The method of claim 44, wherein the second procedure includes dispensing medication.

50. The method of claim 44, wherein the second procedure includes characterizing the tissue with an additional sensor.

51. An in-vivo method, comprising:

providing an endoscope, having an instrument channel;

inserting into the instrument channel an electromagnetic, sensor for tissue characterization, operative in an electromagnetic frequency range of less than 100 Ghz and mounted on a communication line;

extending the sensor, mounted on the communication line, to beyond the reach of the instrument channel;

characterizing a tissue;

inserting a guide wire to the location of the characterized tissue;

removing the sensor for tissue characterization;

inserting a second instrument into the instrument channel, along the guide wire, to the location of the characterized tissue; and

performing a second procedure with the second instrument.

52. The method of claim 51, wherein the electromagnetic sensor for tissue characterization is a nonirradiative electromagnetic sensor.

54. The method of claim 51, wherein the communication line further includes an instrument bundle.

55. The method of claim 51, wherein the second procedure includes taking a biopsy sample.

56. The method of claim 51, wherein the second procedure includes a localized surgery.

57. The method of claim 51, wherein the second procedure includes dispensing medication.

58. The method of claim 51, wherein the second procedure includes characterizing the tissue with an additional sensor.

53. The method of claim 53, wherein the additional sensor is selected from the group consisting of an optical sensor, an x-ray sensor, an RF sensor, a MW sensor, an infrared thermography sensor, or an ultrasound sensor, an MR sensor, an impedance sensor, a temperature sensor, a biosensor, a chemical sensor, a radioactive-emission sensor, and a mechanical sensor.

59. A method for tissue characterization, comprising:

inserting a guide wire intracorporeally;

inserting intracorporeally, along the guide wire, an electromagnetic sensor for tissue characterization, operative in an electromagnetic frequency range of less than 100 Ghz, wherein the sensor is mounted on a communication line; and

characterizing the tissue with the sensor.

60. The method of claim 59, wherein the electromagnetic sensor for tissue characterization is a nonirradiative electromagnetic sensor.

62. The method of claim 59, wherein the communication line includes an instrument bundle.

63. The method of claim 59, and further including:

removing the sensor for tissue characterization after the characterizing the tissue;

inserting a second instrument, mounted on a second communication line, intracorporeally, along the guide wire.

64. The method of claim 63, wherein the second instrument is a biopsy instrument.

65. The method of claim 63, wherein the second instrument is configured for a localized surgery.

66. The method of claim 63, wherein the second instrument is configured for dispensing medication.

67. The method of claim 63, wherein the second instrument is a sensor, selected from the group consisting of an optical sensor, an X-ray sensor, an RF sensor, a MW sensor, an infrared thermography sensor, or an ultrasound sensor, an MR sensor, an impedance sensor, a temperature sensor, a biosensor, a chemical sensor, a radioactive-emission sensor, and a mechanical sensor.

68. The method of claim 63, wherein the second communication line includes an instrument bundle.

61. (canceled)

69. An endoscope system, which comprises:

an endoscope, comprising;

an intracorporeal portions, configured for insertion into a body, and including;

an electromagnetic sensor for tissue characterization, operative in an electromagnetic frequency range of less than 100 Ghz;

a communication line, on which the electromagnetic sensor is mounted; and

an extracorporeal portion, configured for manipulating the intracorporeal portion; and

a control station.

70. The system of claim 69, wherein the control station further includes at least one of a control unit, control buttons, a keyboard, a read/write device, a signal analyzer, and a display screen.

71. The system of claim 69, wherein the electromagnetic sensor is a nonirradiative electromagnetic sensor.