Device, systems, methods and tools for continuous glucose monitoring
First Claim
Patent Images
1. A glucose monitor, comprising:
- at least one substantially cylindrical tissue piercing element having a distal opening, proximal opening, and an interior lumen extending between the distal and proximal openings;
a sensing area in fluid communication with the proximal opening of the at least one substantially cylindrical tissue piercing element;
sensing fluid extending from the sensing area into substantially the entire interior lumen of the at least one substantially cylindrical tissue piercing element; and
a glucose sensor adapted to detect glucose in the sensing fluid within the sensing area.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention includes methods and apparatus for continuous glucose monitoring of a patient. In one aspect a glucose monitor includes a plurality of substantially cylindrical tissue piercing elements adapted to pierce the stratum corneum and enter the epidermis, allowing for the diffusion of glucose from the interstitial fluid into the glucose monitors described herein. In another aspect of the invention, a glucose monitor includes a deformed substrate layer defining a plurality of tissue piercing elements.
175 Citations
88 Claims
-
1. A glucose monitor, comprising:
at least one substantially cylindrical tissue piercing element having a distal opening, proximal opening, and an interior lumen extending between the distal and proximal openings; a sensing area in fluid communication with the proximal opening of the at least one substantially cylindrical tissue piercing element; sensing fluid extending from the sensing area into substantially the entire interior lumen of the at least one substantially cylindrical tissue piercing element; and a glucose sensor adapted to detect glucose in the sensing fluid within the sensing area. - View Dependent Claims (2, 3, 4, 5, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
-
6. The glucose monitor of clam 1 wherein the at least one substantially cylindrical tissue piercing element is tapered near its distal opening.
-
28. A method of in vivo monitoring of an individual'"'"'s interstitial fluid glucose concentration comprising:
-
inserting a distal end of at least one substantially cylindrical tissue piercing element through a stratum corneum area of the individual'"'"'s skin, the at least one tissue piercing element comprising a distal opening, a proximal opening, an interior lumen extending between the distal and proximal openings, and a sensing fluid filling substantially the entire interior lumen; and sensing a glucose concentration of the sensing fluid. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44)
-
-
45. A glucose monitor, comprising:
-
a deformed substrate layer defining a plurality of tissue piercing elements each having a distal opening, a proximal opening and a lumen extending between the distal and proximal openings; a sensing area in fluid communication with the proximal openings of the plurality of metal tissue piercing elements; sensing fluid extending from the sensing area into substantially the entire interior space of the plurality of tissue piercing elements; and a glucose sensor adapted to detect glucose in the sensing fluid within the sensing area. - View Dependent Claims (46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71)
-
-
72. A method of in vivo monitoring of a patient'"'"'s interstitial fluid glucose concentration comprising:
-
inserting distal ends of a plurality of tissue piercing elements defined by a deformed substrate layer through a stratum corneum area of a patient'"'"'s skin, the at least one tissue piercing element comprising a distal opening, a proximal opening, an interior lumen extending between the distal and proximal openings, and a sensing fluid filling substantially the entire interior lumen; and sensing a glucose concentration of the sensing fluid. - View Dependent Claims (73, 74, 75, 76, 77, 78, 79, 80, 81, 83, 84, 85, 86, 87, 88)
-
-
82. The method of claim further comprising adhering the monitor to the subject'"'"'s skin with adhesive.
Specification