MULTIPLE-WIRE SYSTEMS AND METHODS FOR ABLATION OF OCCLUSIONS WITHIN BLOOD VESSELS

• US 20080154153A1
• Filed: 03/06/2008
• Published: 06/26/2008
• Est. Priority Date: 08/25/2004
• Status: Abandoned Application

• Current Assignee: Arizona Medical Systems, LLC
• Original Assignee: Arizona Medical Systems, LLC
• Inventors: Heuser, Richard R.
• Application Number:
  US12/043,675
• Publication Number:
  US 20080154153A1
• Time in Patent Office: Days
• US Class Current: 600/585
• CPC Class Codes: A61M 2025/0004 having two or more concentrically arranged tubes for forming a concentric catheter system
• CPC Class Codes: A61M 2025/0681 Systems with catheter and outer tubing, e.g. sheath, sleeve or guide tube
• CPC Class Codes: A61M 2025/09175 having specific characteristics at the distal tip
• CPC Class Codes: A61M 25/01 Introducing, guiding, advancing, emplacing or holding catheters A61M25/10 takes precedence
• CPC Class Codes: A61M 25/0105 Steering means as part of the catheter or advancing means; Markers for positioning systems for detection of markers A61B
• CPC Class Codes: A61M 25/09 Guide wires
• CPC Class Codes: A61M 25/09041 Mechanisms for insertion of guide wires

Abstract

Multiple-wire systems for the ablation of occlusions within blood vessels. Systems include two or more concentric wires configured for percutaneous insertion in a blood vessel, the wires configured to ablate an occlusion within the blood vessel.

Claims

1. A multiple-wire system for ablation of an occlusion within a blood vessel, comprising:

an outer wire configured for percutaneous insertion in the blood vessel, the outer wire having a proximal end, a distal end, and a generally cylindrical outer surface, wherein the outer wire includes an opening adjacent the proximal end, an opening adjacent the distal end, and a central lumen communicating therebetween;

a second wire configured for insertion in the blood vessel through the central lumen of the outer wire, the second wire having a proximal end, a distal end, and a generally cylindrical outer surface, wherein the second wire includes an opening adjacent the proximal end, an opening adjacent the distal end, and a central lumen communicating therebetween, and wherein the second wire is longer than the outer wire;

an inner wire configured for insertion in the blood vessel through the central lumen of the second wire, the inner wire having a proximal end, a distal end, and a generally cylindrical outer surface, and wherein the inner wire is longer than the second wire; and

a radio-frequency device including a radio-frequency generating device operatively coupled to one or more of the outer wire, the second wire, and the inner wire, wherein the radio-frequency device is configured to deliver radio-frequency energy to one or more of the distal ends of the outer wire, the second wire, and the inner wire.

2. The multiple-wire system of claim 1, wherein the outer wire has a rigidity greater than a rigidity of the second wire, and the rigidity of the second wire is greater than a rigidity of the inner wire.

3. The multiple-wire system of claim 2, wherein the outer wire, the second wire, and the inner wire are formed substantially of metal alloys, wherein the compositions of the metal alloys are varied to produce the greater rigidity of the outer wire with respect to the second wire and the greater rigidity of the second wire with respect to the inner wire.

4. The multiple-wire system of claim 3, wherein the metal alloys include stainless steel, and further wherein the metal alloy of the outer wire contains a greater proportion of stainless steel as compared to the second wire and the metal alloy of the second wire contains a greater proportion of stainless steel as compared to the inner wire.

5. The multiple-wire system of claim 3, wherein the metal alloys are nitinol alloys.

6. The multiple-wire system of claim 1, wherein the inner wire includes an opening adjacent the proximal end, an opening adjacent the distal end, and a central lumen communicating therebetween.

7. The multiple-wire system of claim 6, wherein the central lumen of the inner wire includes a fluid-impervious coating.

8. The multiple-wire system of claim 1, wherein one or more of the outer wire, the second wire, and the inner wire includes a radio-frequency delivery tip positioned at its distal end, the radio-frequency delivery tip configured to receive radio-frequency energy from the radio-frequency device and deliver the radio-frequency energy to the occlusion in the blood vessel for ablation thereof.

9. The multiple-wire system of claim 1, wherein the radio-frequency device is operatively coupled to the outer wire;

and

wherein the outer wire includes a radio-frequency delivery tip positioned at the distal end of the outer wire, the delivery tip configured to receive radio-frequency energy from the radio-frequency device and deliver the radio-frequency energy to the occlusion in the blood vessel for ablation thereof.

10. The multiple-wire system of claim 9, wherein the radio-frequency device is further operatively coupled to the second wire;

and

wherein the second wire includes a radio-frequency delivery tip positioned at the distal end of the second wire, the delivery tip configured to receive radio-frequency energy from the radio-frequency device and deliver the radio-frequency energy to the occlusion in the blood vessel for ablation thereof.

11. The multiple-wire system of claim 10,

wherein the radio-frequency device is further operatively coupled to the inner wire;

and

wherein the inner wire includes a radio-frequency delivery tip positioned at the distal end of the inner wire, the delivery tip configured to receive radio-frequency energy from the radio-frequency device and deliver the radio-frequency energy to the occlusion in the blood vessel for ablation thereof.

12. The multiple-wire system of claim 1,

wherein the radio-frequency device is operatively coupled to the inner wire;

and

wherein the inner wire includes a radio-frequency delivery tip positioned at the distal end of the inner wire, the delivery tip configured to receive radio-frequency energy from the radio-frequency device and deliver the radio-frequency energy to the occlusion in the blood vessel for ablation thereof.

13. The multiple-wire system of claim 12,

wherein the radio-frequency device is further operatively coupled to the second wire;

and

wherein the second wire includes a radio-frequency delivery tip positioned at the distal end of the second wire, the delivery tip configured to receive radio-frequency energy from the radio-frequency device and deliver the radio-frequency energy to the occlusion in the blood vessel for ablation thereof.

14. The multiple-wire system of claim 1, wherein one or more of the outer wire, the second wire, and the inner wire have a textured outer surface that aids with the passage of the respective wire through the blood vessel in response to a user manipulating the respective wire.

15. The multiple-wire system of claim 1,

wherein the inner wire has a textured outer surface that aids with the passage of the inner wire through the blood vessel in response to a user manipulating the inner wire;

and

wherein the central lumen of the second wire has a textured surface that compliments the textured outer surface of the inner wire, so that when the inner wire is manipulated by a user, the inner wire is displaced through the second wire.

16. The multiple-wire system of claim 1,

wherein the outer wire has a textured outer surface that aids with the passage of the outer wire through the blood vessel in response to a user manipulating the outer wire;

and

wherein the second wire has a textured outer surface that aids with the passage of the second wire through the blood vessel in response to a user manipulating the second wire; and

wherein the inner wire has a textured outer surface that aids with the passage of the inner wire through the blood vessel in response to a user manipulating the inner wire.

17. The multiple-wire system of claim 16, wherein the outer wire, the second wire, and the inner wire include a plurality of wound wire strands that define the textured outer surfaces.

18. The multiple-wire system of claim 16, wherein the distal ends of the outer wire, the second wire, and the inner wire each include a cutting edge configured to aid in the passage of the respective wire through the blood vessel.

19. The multiple wire system of claim 1, wherein one or more of the outer wire, the second wire, and the inner wire include a plurality of wound wire strands, the wire strands defining a textured outer surface that aids with the passage of the respective wire through the blood vessel in response to a user manipulating the respective wire about the wire'"'"'s central axis.

20. The multiple-wire system of claim 1, wherein the inner wire is between about 150 cm and about 300 cm long.

21. The multiple-wire system of claim 20, wherein second wire is between about 5 cm and about 25 cm shorter than the inner wire, and the outer wire is between about 5 cm and about 25 cm shorter than the second wire.

22. A multiple-wire system for percutaneous insertion in a blood vessel, comprising:

an outer wire having a proximal end, a distal end, and a generally cylindrical and textured outer surface, wherein the outer wire includes an opening adjacent the proximal end, an opening adjacent the distal end, and a central lumen communicating therebetween, and wherein the textured outer surface is configured to aid with the passage of the outer wire through the blood vessel in response to a user manipulating the outer wire;

a second wire configured for insertion through the central lumen of the outer wire, the second wire having a proximal end, a distal end, and a generally cylindrical and textured outer surface, wherein the second wire is longer than the outer wire, and wherein the textured outer surface is configured to aid with the passage of the second wire through the blood vessel in response to a user manipulating the second wire; and

a radio-frequency device including a radio-frequency generating device operatively coupled to one or both of the outer wire and the second wire, wherein the radio-frequency device is configured to deliver radio-frequency energy to one or both of the distal ends of the outer wire and the second wire.

23. The multiple-wire system of claim 22, wherein the second wire includes an opening adjacent the proximal end, an opening adjacent the distal end, and a central lumen communicating therebetween.

24. The multiple-wire system of claim 23, wherein the central lumen of the second wire includes a fluid-impervious coating.

25. The multiple-wire system of claim 22, wherein the outer wire has a rigidity greater than a rigidity of the second wire.

26. The multiple-wire system of claim 22, further comprising:

an inner wire configured for insertion through the central lumen of the second wire, the inner wire having a proximal end, a distal end, and a generally cylindrical and textured outer surface, wherein the inner wire is longer than the second wire, and wherein the textured outer surface is configured to aid with the passage of the inner wire through the blood vessel in response to a user manipulating the inner wire.

27. The multiple-wire system of claim 26, wherein the inner wire includes an opening adjacent the proximal end, an opening adjacent the distal end, and a central lumen communicating therebetween.

28. The multiple-wire system of claim 26, wherein the outer wire has a rigidity greater than a rigidity of the second wire and the rigidity of the second wire is greater than a rigidity of the inner wire

29. The multiple-wire system of claim 22, wherein the outer wire and the second wire include a plurality of wound wire strands that define the textured outer surfaces.

30. The multiple-wire system of claim 22,

wherein the distal end of the outer wire includes a cutting edge configured to aid in the passage of the outer wire through the blood vessel;

and

wherein the distal end of the second wire includes a cutting edge configured to aid in the passage of the second wire through the blood vessel.

31. The multiple-wire system of claim 22, wherein the central lumen of the outer wire has a textured surface that compliments the textured outer surface of the second wire, so that when the second wire is manipulated by a user, the second wire is displaced through the outer wire.

32. The multiple-wire system of claim 22,

wherein the outer wire includes a plurality of wound wire strands defining the textured outer surface of the outer wire;

and

wherein the second wire includes a plurality of wound wire strands defining the textured outer surface of the second wire.

33. A method of ablating an occlusion within a blood vessel, comprising:

percutaneously inserting into a blood vessel an outer wire having a central lumen;

feeding the outer wire through one or more blood vessels;

feeding a second wire having a central lumen through the central lumen of the outer wire;

feeding an inner wire through the central lumen of the second wire to reach the occlusion;

manipulating one or more of the outer wire, the second wire, and the inner wire to engage the occlusion; and

applying radio-frequency energy to a distal end of one or more of the outer wire, the second wire, and the inner wire to ablate the occlusion.

34. The method of claim 33, wherein the outer wire has a rigidity greater than a rigidity of the second wire, and the rigidity of the second wire is greater than a rigidity greater than the inner wire.

35. The method of claim 34, wherein the outer wire, the second wire, and the inner wire are formed substantially of metal alloys, wherein the compositions of the metal alloys are varied to produce the greater rigidity of the outer wire with respect to the second wire and the greater rigidity of the second wire with respect to the inner wire.

36. The method of claim 35, wherein the metal alloys include stainless steel, and further wherein the metal alloy of the outer wire contains a greater proportion of stainless steel as compared to the second wire and the metal alloy of the second wire contains a greater proportion of stainless steel as compared to the inner wire.

37. The method of claim 35, wherein the metal alloys are nitinol alloys.

38. The method of claim 33, wherein the inner wire has a central lumen, the method further comprising:

injecting a fluid through one or more of the central lumens of the outer wire, the second wire, and the inner wire to ablate the occlusion.

39. The method of claim 33, wherein the outer wire, the second wire, and the inner wire each have a textured outer surface that aids with the passage of the respective wire through the one or more blood vessels, the method further comprising.

40. The method of claim 39,

wherein the textured outer surfaces are each defined by a plurality of wound wire strands;

and

wherein the manipulating one or more of the outer wire, the second wire, and the inner wire includes twisting the respective wire to at least partially screw into the occlusion.

41. A method of ablating an occlusion within a blood vessel, comprising:

percutaneously inserting into a blood vessel an inner wire;

feeding the inner wire through one or more blood vessels;

feeding a second wire having a central lumen over the inner wire;

feeding an outer wire having a central lumen over the second wire;

manipulating one or more of the inner wire, the second wire, and the outer wire to engage the occlusion; and

applying radio-frequency energy to a distal end of one or more of the inner wire, second wire, and outer wire to ablate the occlusion.

42. The method of claim 41, wherein the outer wire has a rigidity greater than a rigidity of the second wire, and the rigidity of the second wire is greater than a rigidity greater than the inner wire.

43. The method of claim 42, wherein the outer wire, the second wire, and the inner wire are formed substantially of metal alloys, wherein the compositions of the metal alloys are varied to produce the greater rigidity of the outer wire with respect to the second wire and the greater rigidity of the second wire with respect to the inner wire.

44. The method of claim 43, wherein the metal alloys include stainless steel, and further wherein the metal alloy of the outer wire contains a greater proportion of stainless steel as compared to the second wire and the metal alloy of the second wire contains a greater proportion of stainless steel as compared to the inner wire.

45. The method of claim 43, wherein the metal alloys are nitinol alloys.

46. The method of claim 41, wherein the inner wire has a central lumen, the method further comprising:

injecting a fluid through one or more of the central lumens of the outer wire, the second wire, and the inner wire to ablate the occlusion.

47. The method of claim 41, wherein the outer wire, the second wire, and the inner wire each have a textured outer surface that aids with the passage of the respective wire through the one or more blood vessels, the method further comprising.

48. The method of claim 47,

wherein the textured outer surfaces are each defined by a plurality of wound wire strands;

and

wherein the manipulating one or more of the outer wire, the second wire, and the inner wire includes twisting the respective wire to at least partially screw into the occlusion.

49. A method of ablating an occlusion within a blood vessel, comprising:

percutaneously inserting into a blood vessel a first wire having a central lumen;

feeding the first wire through one or more blood vessels;

feeding a second wire through the central lumen of the first wire;

feeding a third wire having a central lumen over the first wire;

manipulating one or more of the first wire, the second wire, and the third wire to engage the occlusion; and

applying radio-frequency energy to a distal end of one or more of the first wire, second wire, and third wire to ablate the occlusion.

50. The method of claim 49, wherein the outer wire has a rigidity greater than a rigidity of the second wire, and the rigidity of the second wire is greater than a rigidity greater than the inner wire.

51. The method of claim 50, wherein the outer wire, the second wire, and the inner wire are formed substantially of metal alloys, wherein the compositions of the metal alloys are varied to produce the greater rigidity of the outer wire with respect to the second wire and the greater rigidity of the second wire with respect to the inner wire.

52. The method of claim 51, wherein the metal alloys include stainless steel, and further wherein the metal alloy of the outer wire contains a greater proportion of stainless steel as compared to the second wire and the metal alloy of the second wire contains a greater proportion of stainless steel as compared to the inner wire.

53. The method of claim 51, wherein the metal alloys are nitinol alloys.

54. The method of claim 49, wherein the inner wire has a central lumen, the method further comprising:

injecting a fluid through one or more of the central lumens of the outer wire, the second wire, and the inner wire to ablate the occlusion.

55. The method of claim 49, wherein the outer wire, the second wire, and the inner wire each have a textured outer surface that aids with the passage of the respective wire through the one or more blood vessels, the method further comprising.

56. The method of claim 55,

wherein the textured outer surfaces are each defined by a plurality of wound wire strands;

and

wherein the manipulating one or more of the outer wire, the second wire, and the inner wire includes twisting the respective wire to at least partially screw into the occlusion.