Method and device for subretinal drug delivery
First Claim
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1. A device for treating an eye comprising:
- a piercing member having a length, an outer diameter, a proximal end, a distal end, and a lumen extending between the proximal and distal ends, the distal end being of sufficient sharpness to cause a penetration of the eye conjunctiva and sclera; and
a cannula having a proximal end, a distal end, a lumen extending between the proximal and distal ends, and an outer diameter, wherein the cannula is slidably disposed within the lumen of the piercing member and wherein the distal end of the cannula is extendable beyond the distal end of the piercing member;
wherein the outer diameter of the piercing member is sized to allow the length of the piercing member to be advanced through the penetration, and for self sealing of the penetration upon removal of the piercing member from the eye.
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Abstract
Devices and methods for the treatment of the eye are disclosed. Preferred devices of the invention include a piercing member that is inserted into the eye to create a pathway for a cannula. The cannula is slidably mounted to the piercing member and is adapted to reach a treatment site within the eye at which material is injected into and/or withdrawn from the eye. The outer diameter of the piercing member is small enough to allow for self-sealing of the insertion site of the device upon the device'"'"'s withdrawal therefrom. Also disclosed are methods for the utilizing the devices to treat the eye.
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Citations
22 Claims
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1. A device for treating an eye comprising:
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a piercing member having a length, an outer diameter, a proximal end, a distal end, and a lumen extending between the proximal and distal ends, the distal end being of sufficient sharpness to cause a penetration of the eye conjunctiva and sclera; and a cannula having a proximal end, a distal end, a lumen extending between the proximal and distal ends, and an outer diameter, wherein the cannula is slidably disposed within the lumen of the piercing member and wherein the distal end of the cannula is extendable beyond the distal end of the piercing member; wherein the outer diameter of the piercing member is sized to allow the length of the piercing member to be advanced through the penetration, and for self sealing of the penetration upon removal of the piercing member from the eye. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A device for treating an eye comprising:
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a piercing member having a length, an outer diameter, a proximal end, a distal end, the distal end being of sufficient sharpness to cause a penetration in the eye conjunctiva and sclera; a handle having a length, a proximal end, a distal end, and a substantially hollow portion, the distal end of the handle being mounted to the piercing member, wherein the piercing member and the handle have a lumen therebetween, defining a pathway between the proximal end of the handle and distal end of the piercing member;
a rigid member and cannula slidably disposed within the lumen of the piercing member and the handle, wherein rigid member has a proximal end, a distal end, and a lumen therebetween, and the cannula has a proximal end, a distal end, and a lumen therebetween, and the distal end of the rigid member is connected to the proximal end of the cannula; anda quantity of tubing having a proximal end, a distal end, and a lumen extending therebetween, the distal end of the tubing being disposed within the lumen of the handle and being connected to the proximal end of the rigid member.
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22. A device for treating an eye comprising:
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a piercing member having a length, an outer diameter, a proximal end, a distal end, and a lumen extending between the proximal and distal ends, the distal end being of sufficient sharpness to cause a penetration in the eye conjunctiva and sclera wherein the outer diameter of the piercing member is sized to allow the length of the piercing member to be advanced through the penetration, and for self sealing of the penetration upon removal of the piercing member from the eye; a fluid conduit comprising a cannula having a proximal end, a distal end, a lumen extending between the proximal and distal ends, and an outer diameter; and
a rigid member having a proximal end, a distal end, and a lumen therebetween, wherein the cannula is disposed within the lumen of the rigid member, and wherein the rigid member and cannula are both slidably disposed within the lumen of the piercing member, and wherein the distal end of the cannula is extendable beyond the distal end of the piercing member and the distal end of the rigid member;wherein distal-to-proximal movement and proximal-to-distal movement of the rigid member affects movement of the cannula correspondingly.
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Specification