Real-time optoacoustic monitoring with electophysiologic catheters

• US 20080154257A1
• Filed: 12/22/2006
• Published: 06/26/2008
• Est. Priority Date: 12/22/2006
• Status: Abandoned Application

• Current Assignee: Biosense Webster Incorporated (Johnson & Johnson)
• Original Assignee: Biosense Webster Incorporated (Johnson & Johnson)
• Inventors: Sharareh, Shiva, Lieber, Chad A.
• Application Number:
  US11/644,312
• Publication Number:
  US 20080154257A1
• Time in Patent Office: Days
• US Class Current: 606/41
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00

Abstract

A system and method for opto-acoustic tissue and lesion assessment in real time on one or more of the following tissue characteristics: tissue thickness, lesion progression, lesion width, steam pop, and char formation, system includes an ablation element, laser delivery means, and an acoustic sensor. The invention involves irradiating tissue undergoing ablation treatment to create acoustic waves that have a temporal profile which can be recorded and analyzed by acoustic sampling hardware for reconstructing a cross-sectional aspect of the irradiated tissue. The ablation element (e.g., RF ablation), laser delivery means and acoustic sensor are configured to interact with a tissue surface from a common orientation; that is, these components are each generally facing the tissue surface such that the direction of irradiation and the direction of acoustic detection are generally opposite to each other, where the stress waves induced by the laser-induced heating of the tissue below the surface are reflected back to the tissue surface.

Claims

1. A catheter for opto-acoustic tissue assessment, comprising:

a catheter body;

a tip section distal the catheter body, the tip section being adapted for irradiation and acoustic detection, wherein a tissue is heated by the irradiation to produce an acoustic wave that is detected by a acoustic detector mounted on the tip section and the acoustic detector generates a signal representative of a tissue characteristic.

2. A catheter of claim 1, wherein the tissue is cardiac tissue.

3. A catheter of claim 1, wherein the tip section is also adapted for RF ablation.

4. A catheter of claim 1, wherein the catheter operates in a reflection mode during the opto-acoustic tissue assessment.

5. A catheter of claim 1, wherein the irradiation is a laser pulse.

6. A catheter of claim 1, wherein the tissue is undergoing RF ablation.

7. A catheter of claim 1, wherein the tissue is a lesion resulting from RF ablation.

8. A catheter of claim 1, wherein the tissue characteristic is at least one of the following:

tissue thickness, lesion progression, and lesion width.

19. A method of claim 1, wherein the tissue characteristic is at least one of the following:

tissue thickness, lesion progression, and lesion width.

9. A method of assessing tissue with laser optoacoustic imaging, comprising:

irradiating tissue from a distal end of a catheter to heat said tissue for producing an acoustic wave;

detecting said acoustic wave with an acoustic transducer mounted on said distal end of the catheter;

recording characteristics of the acoustic wave; and

analyzing the acoustic wave to assess a tissue characteristic.

10. A method of claim 9, wherein analyzing the acoustic wave includes analyzing on a temporal basis.

11. A method of claim 9, wherein analyzing the acoustic wave includes analyzing a delay in receive time.

12. A method of claim 9, wherein analyzing the acoustic wave includes analyzing a delay in receive time that is proportional to a distance between the tissue generating the acoustic wave and the distal end of the catheter.

13. A method of claim 9, wherein the tissue is cardiac tissue.

14. A method of claim 9, wherein the catheter is also adapted for RF ablation.

15. A method of claim 9, wherein the opto-acoustic assessment operates in a reflection mode.

16. A method of claim 9, wherein the irradiation is pulsed.

17. A method of claim 9, wherein the tissue is undergoing RF ablation.

18. A method of claim 9, wherein the tissue is a lesion resulting from RF ablation.

20. A system for opto-acoustic tissue assessment, comprising:

a catheter having a distal tip section configured for irradiation and acoustic detection, wherein a tissue is heated by the irradiation to produce an acoustic wave that is detected by a acoustic detector mounted on the tip section and the acoustic detector generates a signal representative of a tissue characteristic;

an electronic scope receiving the signal to record a temporal profile of the acoustic wave; and

a processor to reconstruct an image or profile of the tissue based on the temporal profile.

21. A system of claim 20, wherein the electronic scope device is a digital oscilloscope.

22. A system of claim 20, wherein the tip section of the catheter is also adapted for RF ablation.

23. A system of claim 20, wherein the catheter operates in a reflection mode during the opto-acoustic tissue assessment.

24. A system of claim 20, further comprising a light source to provide the irradiation as a laser pulse.

25. A system of claim 20, wherein the tissue is a lesion resulting from RF ablation.

26. A system of catheter of claim 20, wherein the tissue characteristic is at least one of the following:

tissue thickness, lesion progression, and lesion width.

27. A system of claim 20, wherein the tissue is cardiac tissue.

28. A system for opto-acoustic assessment of cardiac tissue, comprising:

an ablation element configured to ablate the tissue;

laser delivery means for heating the tissue to produce an acoustic wave;

acoustic sensor configured to detect the acoustic wave and generating a signal representative of a tissue characteristic.

29. A system of claim 28, further comprising acoustic sampling hardware configured to receive the signal and record a temporal profile of the acoustic wave.

30. A system of claim 28, further comprising a processor configured to analyze the temporal profile and generate an image or profile of the tissue.

31. A system of claim 28, further comprising a pulsed laser providing irradiation energy to the laser delivery means.

32. A system of claim 28, further comprising an ablation energy source providing ablation energy to the ablation element.