Pulsating Inhaler and a Method of Treating Upper Respiratory Disorders

• US 20080156319A1
• Filed: 05/24/2006
• Published: 07/03/2008
• Est. Priority Date: 06/02/2005
• Status: Abandoned Application

• Current Assignee: RespiNova Ltd
• Original Assignee: RespiNova Ltd
• Inventors: Avni, Yuval
• Application Number:
  US11/916,306
• Publication Number:
  US 20080156319A1
• Time in Patent Office: Days
• US Class Current: 128/200.14
• CPC Class Codes: A61M 11/005 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 11/007 Syringe-type or piston-type sprayers or atomisers
• CPC Class Codes: A61M 11/02 operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised sprayers for horticulture A01G, A01H; killing insects A01M; air humidifying by nozzles F24F6/14, F24F6/18; cooling by spraying F28B, F28C
• CPC Class Codes: A61M 11/042 electrical
• CPC Class Codes: A61M 15/0018 with exhalation check valves
• CPC Class Codes: A61M 15/0035 Piercing means
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 15/02 with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
• CPC Class Codes: A61M 16/0006 with means for creating vibrations in patients' airways
• CPC Class Codes: A61M 16/1075 by influencing the temperature A61M16/1045 takes precedence
• CPC Class Codes: A61M 16/16 Devices to humidify the respiration air A61M16/1045 takes precedence
• CPC Class Codes: A61M 2016/0021 with a proportional output signal, e.g. from a thermistor
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/07 having air pumping means
• CPC Class Codes: A61M 2205/103 rotating
• CPC Class Codes: A61M 2205/106 reciprocating
• CPC Class Codes: A61M 2205/6018 providing set-up signals for the apparatus configuration
• CPC Class Codes: A61M 2205/6045 having complementary physical shapes for indexing or registration purposes
• CPC Class Codes: A61M 2205/8206 battery-operated

Abstract

The present invention discloses a pulsating inhaler, comprising a fluid oscillator providing a focused fluid column with a series of alternating high and low pressures zones; a medicament dispenser adapted for releasing small and constant measures of at least one medicament via said fluid column; and, at least one outlet orifice adapted to direct said focused fluid column towards the respiratory tract of a patient, wherein said small and constant measures of medicament are subjected to the patients while its respiratory tracts are gently and continuously vibrated The present invention also discloses a method of inhaling small and constant measures of medicament while gently and continuously vibrating the patient'"'"'s respiratory tracks by a means of a fluid column characterized by a series of alternating high and low pressures zones.

Claims

1. A pulsating inhaler, comprising:

a. a fluid oscillator providing a focused fluid column with a series of alternating high and low pressures zones;

b. a medicament dispenser adapted for releasing small and constant measures of at least one medicament via said fluid column; and

,

c. at least one outlet orifice adapted to direct said focused fluid column towards the respiratory tract of a patient,

wherein said small and constant measures of medicament are subjected to the patients while its respiratory tracts are gently and continuously vibrated.

2. The inhalator according to claim 1, wherein the fluid is a gas.

3. The inhalator according to claim 2, wherein the fluid is air.

4. The inhalator according to claim 1, wherein the fluid is a liquid.

5. The inhalator according to claim 4, wherein the fluid is water.

6. The inhalator according to claim 1, additionally comprising a heating/cooling means, wherein the temperature of the fluid is conditioned to a predetermined measure before being subjected to the respiratory tracts of the patient.

7. The inhalator according to claim 1, wherein the medicament is in solid phase.

8. The inhalator according to claim 6, wherein the medicament is selected from granular matter, fine particles, powder, sol, gel, sol-gel, glass, encapsulated matter, milled composition or any combination thereof.

9. The inhalator according to claim 1, wherein the medicament is in liquid phase.

10. The inhalator according to claim 8, wherein the medicament is a water miscible composition, water immiscible composition, emulsion, extract, dispersion, suspension, vesiculated solution, aggregated phase or any combination thereof.

11. The inhalator according to claim 1, wherein the medicament is being activated before or while being carried by the fluid column.

12. The inhalator according to claim 1, wherein the medicament is introduced to the dispenser by means of a disposable capsule comprising an envelope to be punctured or alternatively pierced such that a limited measure of the medicament contained in said enveloped is forced toward the pulsed column of fluid in a predetermined flux.

13. The inhalator according to claim 1, wherein the fluid oscillator is a rotating pistol.

14. The inhalator as defined in claim 1 or in any of its dependent claims, comprising:

a. air oscillator (103) providing a focused wind column with a series of alternating high and low pressures zones; and

,

b. at least one outlet orifice (109) adapted to direct said focused fluid column towards or from the respiratory track of a patient,

15. The inhalator as defined in claim 1 or in any of its dependent claims, comprising:

a. a fluid oscillator (203) providing a focused fluid column with a series of alternating high and low pressures zones;

b. a medicament dispenser (209) adapted for releasing small and constant measures of at least one medicament;

c. a fluid dispenser (207); and

,

d. at least one outlet orifice (212) adapted to direct said focused fluid column towards the respiratory track of a patient,

wherein said small and constant measures of medicament are subjected in said fluid to the patients while its respiratory tracks are gently and continuously vibrated.

16. The inhalator according to claim 1, wherein the fluid oscillator is a rotating disc.

17. The inhalator as defined in claim 1 or in any of its dependent claims, comprising:

a. a fluid turbine (307);

b. a medicament dispenser (304) adapted for releasing small and constant measures of at least one medicament via said fluid column;

c. a fluid and medicament oscillator (308) providing a focused wind or air column with a series of alternating high and low medicaments concentration;

said oscillator is one or more rotating discs, especially a discs comprising a missing edge; and

,

d. at least one outlet orifice (306) adapted to direct said focused fluid column towards the respiratory track of a patient,

wherein said small and constant measures of medicament are subjected to the patients while its respiratory tracks are gently and continuously vibrated.

18. The inhalator according to claim 1, additionally comprising at least one air flow valve adapted to provide medicament dispersing at both inhalation and exhalation steps of the respiratory mechanism.

19. The inhalator as defined in claim 1 or in any of its dependent claims, wherein the medicament delivery is provided by 2D or 3D specific and predetermined fitting mechanism or by any other physical parameter.

20. The inhalator according to claim 1 or to any of its dependent claims, additionally comprising one or more dispensing means being either active or passive means, adapted to force or purge at least a portion of the dispersed material towards a predetermined, e.g., focused target being either adjacent to the invented device or located in a remote location.

21. A method of inhaling small and constant measures of medicament while gently and continuously vibrating the patient'"'"'s respiratory tracks by a means of a fluid column characterized by a series of alternating high and low pressures zones.

23. The method according to claim 21, especially adapted for preventing airways collapse during expiration by providing PCPAP.

24. The method according to claim 21, especially adapted for treating rhinitis and allergic rhinitis, rhinosinusitis, URTI, Asthma and COPD.

22. A method of treating upper respiratory diseases especially useful for reducing dyspnea, edema, spasm and collapse of the airways, comprising:

vibrating the inhaled and/or exhaled air column while dispensing accurate and small dosage of medicaments to the respiratory tracks and peripheral regions wherein reducing the deposition of said medicament into the mouth cavity.