Recovery system

• US 20080156377A1
• Filed: 01/11/2007
• Published: 07/03/2008
• Est. Priority Date: 12/29/2006
• Status: Abandoned Application

• Current Assignee: Eisai Research & Devlopment Management Co., Ltd.
• Original Assignee: Eisai Research & Devlopment Management Co., Ltd.
• Inventors: Mann, Brad
• Application Number:
  US11/652,213
• Publication Number:
  US 20080156377A1
• Time in Patent Office: Days
• US Class Current: 137/263
• CPC Class Codes: A61J 3/002 Compounding apparatus specially for enteral or parenteral nutritive solutions bottling liquids B67C
• CPC Class Codes: B01L 9/06 Test-tube stands; Test-tube holders
• CPC Class Codes: B09B 2101/02 Gases or liquids enclosed in discarded articles, e.g. aerosol cans or cooling systems of refrigerators
• CPC Class Codes: B09B 3/00 Destroying solid waste or transforming solid waste into something useful or harmless
• CPC Class Codes: Y10T 137/4807 Tank type manifold [i.e., one tank supplies or receives from at least two others]

Abstract

A system allows for the safe, rapid, efficient recovery of a drug solution from sealed vials. The system is closed so that highly potent compounds can later be recovered and reworked without large investment in further engineering controls.

Claims

1. An apparatus for recovering a solution from a plurality of stoppered vials, the apparatus comprising:

a recovery subsystem comprising;

a vial positioner capable of positioning a plurality of stoppered vials in a corresponding plurality of liquid recovery positions in response to a first positioner signal and capable of releasing the plurality of stoppered vials in response to a second positioner signal;

a needle holder holding a corresponding plurality of hollow point needles, each hollow point needle being over a corresponding vial; and

an actuator capable of translating the needle holder and the vial positioner between first and second positions relative to each other in response to corresponding first and second actuator signals, wherein in the first position the needles are spaced relative to the vial stoppers and wherein in the second position the needles puncture the vial stoppers;

a recovery pump subsystem comprising;

a recovery pump to extract a solution from the plurality of vials;

a recovery vessel to collect the solution from the plurality of vials; and

tubing connecting the plurality of needles to the recovery pump and to the recovery vessel;

a conveyor subsystem capable of transporting the plurality of vials into the recovery subsystem in response to a first conveyor signal and out of the recovery subsystem in response to a second conveyor signal; and

a controller in communication with the vial positioner, actuator, and conveyor mechanism and comprising instructions to apply the first and second positioner signals, first and second actuator signals, and first and second conveyor signals such that the conveyor subsystem transports the plurality of vials into the recovery subsystem, the recovery subsystem recovers solution from within them, and the conveyor subsystem transports the plurality of vials out of the recovery subsystem.

2. The apparatus of claim 1, wherein the controller further comprises instructions to repeatedly apply the first and second positioner signals, first and second actuator signals, and first and second conveyor signals such that the conveyor subsystem transports each plurality of multiple pluralities of vials into the recovery subsystem, the recovery subsystem recovers solution from within each plurality of said multiple pluralities of vials, and the conveyor subsystem transports each plurality of said multiple pluralities of vials out of the recovery subsystem.

3. The apparatus of claim 1, further comprising a flip-cap remover configured to remove flip-caps from the plurality of stoppered vials before the conveyor subsystem transports the vials into the recovery subsystem.

4. The apparatus of claim 3, wherein the flip-cap remover comprises a gripper belt and a wedge-shaped tool, wherein the gripper belt advances each vial of the plurality of vials past the wedge shaped tool such that the wedge shaped tool removes the flip-cap from the vial.

5. The apparatus of claim 4, wherein the flip-cap remover further comprises a gas stream to blow the removed flip-cap into an adjacent catch tray.

6. The apparatus of claim 1, wherein the vial positioner comprises a vial counter in communication with the controller and capable of counting the number of vials that the conveyor subsystem transports into vial positioner.

7. The apparatus of claim 6, wherein the vial positioner comprises a stop cylinder capable of moving into and out of the path of the vials in response to corresponding first and second stop signals, and wherein the controller is in communication with the stop cylinder and provides the first and second stop signals according to the number of vials the vial counter counts.

8. The apparatus of claim 1, wherein the vial positioner includes a vial stop and a vial locator that moves toward the vial stop in response to the first positioner signal and moves away from the vial stop in response to the second positioner signal.

9. The apparatus of claim 8, wherein the vial locator comprises a plurality of grooves, each groove sized and positioned to center a corresponding vial of the plurality of vials.

10. The apparatus of claim 1, wherein the actuator is a pneumatic cylinder.

11. The apparatus of claim 1, further comprising an accumulation area adjacent the conveyor subsystem into which a user manually loads the plurality of vials.

12. The apparatus of claim 1, wherein the conveyor subsystem comprises a conveyor belt.

13. The apparatus of claim 1, wherein the controller is in communication with the recovery pump and capable of applying first and second pump signals to respectively turn the recovery pump off and on.

14. The apparatus of claim 1, wherein the recovery pump is a peristaltic pump.

15. The apparatus of claim 1, further comprising an empty vial collection bin for collecting the plurality of vials after recovering solution from them.

16. The apparatus of claim 1, further comprising a reconstitution subsystem, the reconstitution subsystem comprising:

a reconstitution pump to pump solvent into the plurality of vials;

a reconstitution vessel to store the solvent; and

tubing connecting the plurality of needles to the reconstitution pump and to the reconstitution vessel,

wherein the controller is capable of turning off and on each of the reconstitution pump and the recovery pump and comprises instructions to turn on the reconstitution pump so as to pump solvent into the plurality of vials, to turn off the reconstitution pump, to turn on the recovery pump so as to extract solution from the plurality of vials, and to turn off the recovery pump.

17. The apparatus of claim 16, wherein the tubing comprises a plurality of reconstitution valves, each reconstitution valve between a needle and the reconstitution pump, and a plurality of recovery valves, each recovery valve between a needle and the recovery pump, wherein the controller is capable of opening and closing the plurality of reconstitution valves and the plurality of recovery valves, and wherein the controller comprises instructions to open the reconstitution valves and close the recovery valves when the reconstitution pump is on, and instructions to close the reconstitution valves and open the recovery valves when the recovery pump is on.

18. The apparatus of claim 16, wherein the solvent is selected to dissolve a material within the vials and thus form the solution to be recovered.