Synthesis of 2-Methyl-4-(4-Methyl-1-Piperazinly)-10H-Thieno(2,3-B) (1,5) Benzodiazepine and Salts Thereof

• US 20080161557A1
• Filed: 03/17/2005
• Published: 07/03/2008
• Est. Priority Date: 03/18/2004
• Status: Abandoned Application

• Current Assignee: Lek Pharmaceuticals, d.d. (Novartis Ag)
• Original Assignee: Lek Pharmaceuticals, d.d. (Novartis Ag)
• Inventors: Ludescher, Johannes, Sturm, Hubert, Copar, Anton, Mesar, Tomaz
• Application Number:
  US10/598,816
• Publication Number:
  US 20080161557A1
• Time in Patent Office: Days
• US Class Current: 540/557
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: C07D 495/04 Ortho-condensed systems

Abstract

The invention belongs to the field of organic chemistry and relates to a new process for the purification of olanzapine comprising preparation of acid addition salts of olanzapine and transformation thereof into a pharmaceutically acceptable pure and discoloured final product. The present invention also relates to new processes for the preparation of pure olanzapine.

Claims

1. A process for the purification of olanzapine characterized in that said process comprises the following steps:

a) mixing olanzapine with an organic acid in an organic solvent or a mixture of organic solvents to form an olanzapine acid addition salt,

b) precipitating and isolating the olanzopine acid addition salt and,

c) transformation of the olanzapine acid addition salt to olanzapine.

2. The process according to claim 1 wherein the organic acid in step (a) is selected from the group consisting of sulfonic acids or carboxylic acid.

3. The process according to claim 2 wherein the carboxylic acid is selected from the group consisting of fumaric acid and benzoic acid.

4. The process according to claim 1 wherein the organic solvent in step (a) is selected from the group consisting of tetrahydrofuran, acetone, dimethylformamide and acetonitrile.

5. The process according to claim 1 wherein the mixture of organic solvents in step (a) is a mixture of tetrahydrofuran with at least one polar solvent.

6. The process according to claim 5 wherein said polar solvent is selected from the group consisting of dimethylformamide, dimethylacetamide, N-methylpyrrolidone, 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone, 1,3-imethyl-2-imidazolidinone, tetramethylurea, dimethyl sulfoxide, sulfolane, acetone and acetonitrile.

7. The process according to claim 1 characterized in that step (c) comprises the following substeps:

i) dissolving an acid addition salt of olanzapine in water,

ii) adjusting pH of the obtained solution to about 8-10,

iii) extracting olanzapine from the water phase to the organic solvent phase and

iv) isolating the acid addition salt of olanzapine from the organic solvent phase by concentrating the solution and separation of the crystals.

35. Olanzapine prepared according to the processes disclosed in claim 1 characterized in that N-desmethylolanzapine content in the final product of olanzapine is less than 0.1%.

36. Olanzapine prepared according to the processes disclosed in claim 1 that contains less than 0.05% of piperazine 1,4-bis-4-yl-(2-methyl)-10H-thieno-[2,3-b][1,5]benzodiazepine.

8-21. -21. (canceled)

22. A process for the preparation of olanzapine in the form of an acid addition salt characterized in that said process comprises the following steps:

a) 4-amino-2-methyl-10H-thieno[2,3-b][1,5]benzodiazepine hydrochloride is reacted with N-methylpiperazine to yield olanzapine and

b) the obtained olanzapine is transformed to an acid addition salt thereof.

23. The process according to claim 22 characterized in that step (b) comprises the following substeps:

i) the obtained reaction mixture is diluted with water,

ii) the diluted reaction mixture is extracted with an organic solvent,

iii) the organic phase is evaporated and the residue is diluted with a second solvent to obtain a solution,

iv) an organic acid is added to the solution to precipitate olanzapine acid addition salt and

v) precipitated olanzapine acid addition salt is isolated by separation of crystals.

24. A process for the preparation of olanzapine in the form of an acid addition salt characterized in that said process comprises the following steps:

a) N-desmethylolanzapine is reacted with a methylating agent to yield olanzapine,

b) the obtained reaction mixture is diluted with water and acidified with an acid,

c) to the reaction mixture, an organic solvent is added and the phases are separated,

d) the obtained water phase is neutralized and olanzapine is extracted with an organic solvent to obtain the organic solvent phase and

e) an organic acid or substituted organic acid or an organic acid derivative of formula RX;

wherein R represents an organic radical such as acetyl, propionyl, chloroacetyl and X is selected from a group of Cl, Br or I;

or an organic acid anhydride;

is added to the organic phase to form a N substituted N-desmethylolanzopine derivative of formula 2

25. The process according to claim 24 wherein the organic solvent in steps (c) and (d) is a chlorinated solvent.

26. The process according to claim 25 wherein said chlorinated solvent is methylene chloride.

27. The process according to claim 24 wherein the organic solvent in steps (c) and (d) is methylene chloride and said second solvent in step (f) is methanol.

28-34. -34. (canceled)

37-43. -43. (canceled)