Detecting Prolonged Myocardial Repolarization Indicative of Cardiac Condition
First Claim
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1. A method for detecting prolonged myocardial repolarization as an indicator of transmural ischemia or infarction in a mammalian subject, comprising the steps of:
- obtaining baseline electrocardiogram data derived from the subject;
performing an electrocardiogram on the subject after the baseline data was derived from the subject; and
comparing the baseline electrocardiogram data with data from the electrocardiogram to determine whether the time interval of myocardial repolarization is increased.
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Abstract
The present invention comprises methods and apparatus for detecting prolonged myocardial repolarization as an indicator of cardiac conditions, including without limitation, transmural ischemia. In some embodiments, without limitation, the present invention comprises methods and apparatus to detect prolonged repolarization using electrocardiographic and electrophysiological tools and measurements.
10 Citations
39 Claims
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1. A method for detecting prolonged myocardial repolarization as an indicator of transmural ischemia or infarction in a mammalian subject, comprising the steps of:
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obtaining baseline electrocardiogram data derived from the subject; performing an electrocardiogram on the subject after the baseline data was derived from the subject; and comparing the baseline electrocardiogram data with data from the electrocardiogram to determine whether the time interval of myocardial repolarization is increased. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method for detecting prolonged myocardial repolarization as an indicator of transmural ischemia or infarction in a mammalian subject, comprising the steps of:
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obtaining baseline cardiac electrical data derived from the subject; measuring cardiac electrical activity in the subject after the baseline data was derived from the subject; and comparing the baseline data with data from the measurement of the cardiac electrical activity to determine whether the time interval of myocardial repolarization is increased. - View Dependent Claims (8, 9)
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10. A method of detecting myocardium at risk or myocardial viability by measurement of changes in myocardial repolarization in a mammalian subject, comprising the steps of:
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performing an electrocardiogram on the subject to obtain baseline electrocardiogram data; performing a clinical procedure on the subject; monitoring the subject'"'"'s electrocardiogram during the clinical procedure to obtain electrocardiogram data; and comparing the baseline electrocardiogram data with the electrocardiogram data from the clinical procedure to determine whether the time interval of myocardial repolarization is changed during the procedure. - View Dependent Claims (11)
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12. A method of detecting myocardium at risk or myocardial viability by measurement of changes in myocardial repolarization in a mammalian subject, comprising the steps of:
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measuring baseline cardiac electrical data in the subject; performing a clinical procedure on the subject; measuring cardiac electrical data in the subject during the clinical procedure; and comparing the baseline data with the cardiac electrical data from the clinical procedure to determine whether the time interval of myocardial repolarization is changed during the procedure. - View Dependent Claims (13, 14, 15)
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16. A method of detecting ischemic preconditioning by measurement of changes in myocardial repolarization in a mammalian subject, comprising steps of:
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initiating an electrocardiogram on the subject; performing a first step of a clinical procedure on the subject; capturing first electrocardiogram data from the subject during the time period in which the first step of the clinical procedure was performed; performing one or more additional steps of a clinical procedure on the subject; capturing electrocardiogram data from the one or more additional steps of a clinical procedure; and comparing the first electrocardiogram data with electrocardiogram data from the one or more additional steps to determine whether the time interval of myocardial repolarization is changed between the first step of the clinical procedure and any of the subsequent steps. - View Dependent Claims (17)
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18. A method of detecting ischemic preconditioning by measurement of changes in myocardial repolarization in a mammalian subject, comprising steps of:
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initiating the measurement of cardiac electrical data in the subject; performing a first step of a clinical procedure on the subject; capturing cardiac electrical data from the subject during the time period in which the first step of the clinical procedure was performed; performing one or more additional steps of a clinical procedure on the subject; capturing cardiac electrical data from the one or more additional steps of a clinical procedure; and comparing the first cardiac electrical data with cardiac electrical data from the one or more additional steps to determine whether the time interval of myocardial repolarization is changed between the first step of the clinical procedure and any of the subsequent steps. - View Dependent Claims (19, 20, 21)
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22. An electronic apparatus for detecting prolonged myocardial repolarization as an indicator of transmural ischemia or infarction in a mammalian subject, comprising:
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Means for storing baseline electrocardiogram data derived from the subject; Means for performing an electrocardiogram on the subject after the baseline data was derived from the subject; and Means for comparing the baseline electrocardiogram data with data from the electrocardiogram to determine whether the time interval of myocardial repolarization is increased. - View Dependent Claims (23, 24)
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25. An electronic apparatus for detecting prolonged myocardial repolarization as an indicator of transmural ischemia or infarction in a mammalian subject, comprising:
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Means for storing baseline cardiac electrical data derived from the subject; Means for measuring cardiac electrical data in the subject after the baseline data was derived from the subject; and Means for comparing the baseline data with data from the measurement of cardiac electrical data from the subject to determine whether the time interval of myocardial repolarization is increased. - View Dependent Claims (26, 27, 28, 29)
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30. An electronic apparatus for detecting prolonged myocardial repolarization as an indicator of myocardium at risk or myocardial viability in a mammalian subject, comprising:
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Means for storing baseline cardiac electrical data derived from the subject; Means for measuring cardiac electrical data in the subject after the baseline data was derived from the subject; and Means for comparing the baseline data with data from the measurement of cardiac electrical data from the subject to determine whether the time interval of myocardial repolarization is increased. - View Dependent Claims (31, 32, 33, 34)
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35. An electronic apparatus for detecting prolonged myocardial repolarization as an indicator of ischemic preconditioning in a mammalian subject, comprising:
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Means for storing baseline cardiac electrical data derived from the subject; Means for measuring cardiac electrical data in the subject after the baseline data was derived from the subject; and Means for comparing the baseline data with data from the measurement of cardiac electrical data from the subject to determine whether the time interval of myocardial repolarization is increased. - View Dependent Claims (36, 37, 38, 39)
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Specification