MICROPORE DELIVERY OF ACTIVE SUBSTANCES

• US 20080161782A1
• Filed: 10/26/2007
• Published: 07/03/2008
• Est. Priority Date: 10/26/2006
• Status: Abandoned Application

• Current Assignee: Reliant Technologies, Inc. (Bausch Health Cos., Inc.)
• Original Assignee: Reliant Technologies, Inc. (Bausch Health Cos., Inc.)
• Inventors: Chan, Kin F., Hantash, Basil M., Frangineas, George, Bedi, Vikramaditya P.
• Application Number:
  US11/925,697
• Publication Number:
  US 20080161782A1
• Time in Patent Office: Days
• US Class Current: 606/9
• CPC Class Codes: A61B 18/203 applying laser energy to the outside of the body
• CPC Class Codes: A61B 2017/00765 Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
• CPC Class Codes: A61B 2018/00452 Skin
• CPC Class Codes: A61K 31/375 Ascorbic acid, i.e. vitamin C; Salts thereof
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders

Abstract

A method and device for delivering active substances into and through the skin for treatment of the skin during and/or following fractional laser radiation treatment of the skin are described.

Claims

1. A method of delivering vitamin C into the skin for local treatment of the skin of a subject in need thereof, the method comprising:

irradiating skin with laser irradiation to form a plurality of micropore channels wherein the micropore channels extend into a dermal layer of the skin; and

applying vitamin C into the micropore channel.

2. The method of claim 1, wherein the vitamin C is applied 1 minute after the formation of the plurality of micropore channels.

3. The method of claim 1, wherein the vitamin C is applied 1 hour after the formation of the plurality of micropore channels.

4. The method of claim 1, wherein the vitamin C is applied 1 day after the formation of the plurality of micropore channels.

5. The method of claim 1, wherein the plurality of micropore channels are elongated.

6. The method of claim 1, wherein viable tissue separates the plurality of elongated micropore channels.

7. The method of claim 1, wherein the vitamin C comprises a cosmetically effective amount of a form of vitamin C in a cosmetically acceptable carrier.

8. An apparatus for treating skin, the apparatus comprising:

a handpiece movable over skin wherein the handpiece is arranged to receive an optical beam and focus the optical beam at a plurality of spaced-apart locations on the skin thereby creating a plurality of voids in the skin for the deposition of a composition.

9. The apparatus of claim 8, further comprising an applicator arranged to deposit a composition in the voids following the formation of the voids.

10. The apparatus of claim 9, wherein the applicator further comprises a removable tip that attaches to the handpiece.

11. The apparatus of claim 8, wherein the composition is a cosmetically effective amount of vitamin C in a cosmetically acceptable carrier.

12. The apparatus of claim 8, wherein the composition is a cosmetically effective amount of an antioxidant.

13. The apparatus of claim 8, wherein viable tissue separates the plurality of voids.

14. The apparatus of claim 13, wherein the viable tissue separating any two voids is between 50 and 500 μ

m at its narrowest point.

15. The apparatus of claim 8, wherein the voids are created with a density of 200-4000 voids per cm² in a single pass.

16. The apparatus of claim 8, wherein the voids are created at a rate of 10 to 5000 per second.

17. The apparatus of claim 8, wherein the voids are created at a rate of 100 to 5000 per second.

18. The apparatus of claim 8, wherein the pulse energy is 5 to 40 mJ per void.

19. The apparatus of claim 8, further comprising a scanner.

20. The apparatus of claim 19, wherein the scanner comprises a reflective rotating scanner.

21. The apparatus of claim 19, wherein the scanner comprises one or more galvanometer scanners.

22. The apparatus of claim 8, wherein the optical beam is emitted by a laser.

23. The apparatus of claim 22, wherein the laser is a CO₂ laser with a wavelength of about 10.6 μ

m.

24. The apparatus of claim 8, wherein the optical beam has an absorption coefficient in water of about 100 to 12,300 cm⁻

1.

25. The apparatus of claim 8, wherein the optical beam has an absorption coefficient in water of about 500 to 1000 cm⁻

1.

26. The apparatus of claim 8, wherein the voids are about 200 μ

m to 4 mm in depth.

27. The apparatus of claim 8, further comprising a vacuum that removes debris that is removed from the skin during creation of the voids.

28. The apparatus of claim 8, further comprising a system that creates a positive pressure in a chamber containing the composition.

29. The apparatus of claim 8, wherein the voids are elongated.

30. A kit for use with a laser delivery system comprising:

a handpiece movable over skin wherein the handpiece is arranged to receive a laser beam and focus the laser beam at a plurality of spaced-apart locations on the skin thereby creating a plurality of voids in the skin for the deposition of a composition, and

an applicator arranged to deposit a composition in the voids following the formation of the voids.

31. A method of delivering an active substance into the skin for local treatment of resurfaced skin, the method comprising:

selecting a region of skin in need of resurfacing treatment and treatment with an active substance;

irradiating skin with laser irradiation to ablate tissue to form a plurality of micropore channels wherein the micropore channels extend into a dermal layer of the skin, thereby resurfacing the region of skin and increasing permeability of the region of skin to an active substance; and

applying the active substance to the region of skin.

32. The method of claim 31, wherein the laser irradiation is provided by a CO₂ laser system which delivers the irradiation in a fractional manner.

33. The method of claim 31, wherein the active substance is an antioxidant composition.

34. The method of claim 31, wherein the active substance is applied in the form of a hydrogel mask.

35. The method of claim 31, wherein the active substance is applied immediately following the laser irradiation.

36. The method of claim 31, wherein the active substance is applied repeatedly up to one month following the laser irradiation.