Remodeling Device for Aneurysms

• US 20080161936A1
• Filed: 10/14/2005
• Published: 07/03/2008
• Est. Priority Date: 10/15/2004
• Status: Active Grant

• Current Assignee: Codman & Shurtleff Incorporated (Johnson & Johnson)
• Original Assignee: Cordis Neurovascular, Inc. (Johnson & Johnson)
• Inventors: Jones, Donald K., Sherman, Darren R., Feller, Frederick
• Granted Patent: US 7,875,044 B2
• Time in Patent Office: Days
• US Class Current: 623/23.76
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12118 for positioning in conjunction with a stent
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 2017/12054 Details concerning the detachment of the occluding device from the introduction device
• CPC Class Codes: A61F 2002/823 Stents, different from stent-grafts, adapted to cover an aneurysm

Abstract

A method of occluding a defect in the wall of a body vessel is provided. An outlet portion of a microcatheter is delivered to the defect, then at least a body portion of a thin film occlusion device is radially expanded from a collapsed orientation to a deployed orientation for engaging the microcatheter and covering at least a portion of the defect. Thereafter, an embolic media is released into the defect from the microcatheter for facilitating thrombosis. The body portion of the occlusion device is substantially porous in the collapsed orientation, but substantially non-porous in the deployed orientation for preventing prolapse of the embolic media into the body vessel.

Claims

1. A method of occluding at least a portion of a defect in a wall of a body vessel, comprising:

providing a microcatheter capable of deploying an embolic material;

providing a delivery catheter housing an occlusion device in a collapsed orientation, wherein the occlusion device comprises a thin film mesh including;

a proximal end portion associated with a body portion, a plurality of slot members associated with said body portion, and a plurality of slit members associated with said proximal end portion, wherein said slot members are in a generally open condition and said slit members are in a generally closed condition when the occlusion device is in said collapsed orientation;

positioning at least an outlet portion of said microcatheter at the defect;

ejecting at least a portion of the occlusion device from a downstream end of the delivery catheter;

positioning the occlusion device adjacent to the defect;

providing for radial expansion of the occlusion device to a deployed orientation within the body vessel at which said slot members are in a generally closed condition and said slit members are in a generally open condition and such that a body portion of the occlusion device at least partially covers the defect and engages at least a portion of the microcatheter; and

ejecting said embolic material into the defect from said outlet portion of the microcatheter.

2. The method of claim 1, wherein said providing of an occlusion device provides a support structure for supporting at least one of said proximal end portions and said body portion.

3. The method of claim 1, wherein said providing of an occlusion device provides a distal end portion associated with said body portion, having a substantially closed end configuration, and having a plurality of slit members in a generally closed condition when the occlusion device is in said collapsed orientation and in a generally open condition with radial expansion movement of the occlusion device to said deployed orientation within the body vessel.

4. The method of claim 1, further including longitudinally foreshortening and radially expanding at least the portions of said occlusion device associated with said slot members and said slit members upon movement of the occlusion device to the deployed orientation.

5. The method of claim 1, wherein said providing of the occlusion device provides the body portion and proximal end portion of the occlusion device of a material having shape memory properties.

6. The method of claim 5, wherein the material having shape memory properties is nitinol.

7. The method of claim 6, wherein the nitinol is a martensite thin film.

8. The method of claim 6, wherein the nitinol is an austenite thin film that transitions from martensite to austenite upon exposure to human body temperature.

9. The method of claim 1, further including providing the slot members in said generally closed condition and configuring the body portion of the occlusion device to prevent the embolic material from prolapsing into the body vessel.

10. A method of occluding at least a portion of a defect in a wall of a body vessel, comprising:

providing a microcatheter capable of deploying an embolic material;

providing an occlusion device in a collapsed orientation, the occlusion device comprising a thin film mesh including a proximal end portion and a distal end portion associated with a body portion, and wherein said body portion is substantially porous and said proximal end portion and said distal end portion are substantially non-porous in said collapsed orientation and said body portion is substantially non-porous and said proximal end portion and said distal end portion are substantially porous in said deployed orientation;

positioning at least an outlet portion of the microcatheter at the defect;

positioning the occlusion device adjacent to the defect;

radially expanding the occlusion device to a deployed orientation, such that a body portion of the occlusion device at least partially covers the defect and engages at least a portion of the microcatheter; and

ejecting the embolic material into the defect from said outlet portion of the microcatheter.

11. The method of claim 10, further including providing the body portion, proximal end portion and distal end portion of the occlusion device of a material having shape memory properties.

12. The method of claim 11, wherein the material having shape memory properties is nitinol.

13. The method of claim 12, wherein the nitinol is a martensite thin film.

14. The method of claim 12, wherein the nitinol is an austenite thin film that transitions from martensite to austenite upon exposure to human body temperature.

15. A system for occluding at least a portion of a defect in a wall of a body vessel, comprising:

a microcatheter capable of deploying an embolic material to the defect; and

an occlusion device capable of moving from a collapsed orientation to a deployed orientation, wherein said occlusion device comprises a thin film mesh including;

a body portion engageable with at least a portion of the defect and at least a portion of the microcatheter when the occlusion device is in said deployed orientation, and

a plurality of slot members associated with said body portion, wherein said slot members are in a generally open condition when the occlusion device is in said collapsed orientation and said slot members are in a generally closed condition with radial expansion movement and longitudinal foreshortening movement of the occlusion device to said deployed orientation within the body vessel.

16. The system of claim 15, wherein said occlusion device further comprises a proximal end portion associated with said body portion and a plurality of slit members associated with said proximal end portion, wherein said slit members are in a generally closed condition when the occlusion device is in said collapsed orientation and said slit members are in a generally open condition with radial expansion movement and longitudinal foreshortening movement of the occlusion device to said deployed orientation within the body vessel.

17. The system of claim 15, wherein said occlusion device further comprises an engagement member associated with said proximal end portion for selective removal of the occlusion device from a body vessel or repositioning of the occlusion device in a body vessel.

18. The system of claim 15, wherein said occlusion device further comprises a distal end portion associated with said body portion, having a substantially closed end configuration, and having a plurality of slit members associated with said distal end portion, wherein said slit members are in a generally closed condition when the occlusion device is in said collapsed orientation and said slit members are in a generally open condition with radial expansion movement and longitudinal foreshortening movement of the occlusion device to said deployed orientation within the body vessel.

19. The system of claim 15, wherein said occlusion device further comprises a support structure for supporting at least said body portion.

20. The system of claim 15, wherein said occlusion device further comprises a plurality of thin film layers, at least one of said layers having a plurality of slit members, at least one of said layers having a plurality of slot members, and at least some of said slits of one of said film layers are not in full alignment with any slot of another of said film layers.

21. The system of claim 15, wherein said body portion of the occlusion device is comprised of a material having shape memory properties.

22. The system of claim 21, wherein said material having shape memory properties is nitinol.

23. The system of claim 22, wherein said nitinol is a martensite thin film.

24. The system of claim 22, wherein said nitinol is an austenite thin film that transitions from martensite to austenite upon exposure to human body temperature.

25. The system of claim 15, wherein said body portion of the occlusion device is comprised of a material having a thickness greater than about 0.1 microns and less than about 5 microns.