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Pain-Sensitive Therapeutic Wound Dressing

  • US 20080166397A1
  • Filed: 03/04/2008
  • Published: 07/10/2008
  • Est. Priority Date: 04/28/2003
  • Status: Active Grant
First Claim
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1. A wound dressing comprising a therapeutic agent and a matrix comprising polymers joined by cross-linkages which cross-linkages comprise oligopeptidic sequences which are cleavable by a kallikrein such that the rate of release of the therapeutic agent increases in the presence of the protease, wherein the oligopeptidic sequence comprises -Phe-Arg-Ser-Ser-Arg-Gln- (SEQ ID NO:

  • 1) or Met-Ile-Ser-Leu-Met-Lys-Arg-Pro-Gln (SEQ ID NO;

         2).

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