BIOARTIFICIAL LIVER SYSTEM
First Claim
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1. A method of forming spheroid aggregates, said method comprising:
- a) providing a reservoir having a plurality of hepatocytes in fluid; and
b) rocking said plurality of hepatocytes at a frequency and for a duration sufficient for spheroid aggregates to form.
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Abstract
A bioartificial liver system is described that incorporates a cell reservoir and hepatocyte spheroids to both increase the number of and longevity of cells in the system. Additional methods are also described for forming spheroid aggregates from isolated hepatocytes.
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Citations
6 Claims
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1. A method of forming spheroid aggregates, said method comprising:
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a) providing a reservoir having a plurality of hepatocytes in fluid; and b) rocking said plurality of hepatocytes at a frequency and for a duration sufficient for spheroid aggregates to form. - View Dependent Claims (2, 3, 4, 5, 6)
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Specification