PHARMACEUTICAL PRODUCT CONTAINING PROGESTIN, GENISTEIN, AND VITAMIN D COMPOUND
First Claim
1. A pharmaceutical product comprising multiple daily sequential dosages, said product comprising a progestin, genistein and an estrogen, said estrogen selected from the group consisting of estrone, estrone sulfate, estrone sulfate piperazine salt, estradiol and estriol, and their esters, mestranol, conjugated equine estrogen, esterified estrogens, estropipate, 17α
- -ethinylestradiol, esters and ethers of 17α
-ethinylestradiol, 17beta-estradiol, estradiol valerate, piperazine estrone sulphate, estriol succinate, and polyestrol phosphate.
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Abstract
A pharmaceutical product comprising multiple daily sequential dosages, said product comprising a progestin, genistein, and an estrogen, and optionally a Vitamin D compound. The estrogen is selected from the group consisting of estrone, estrone sulfate, estrone sulfate piperazine salt, estradiol and estriol, and their esters, mestranol, conjugated equine estrogen, esterified estrogens, estropipate, 17α-ethinylestradiol, esters and ethers of 17α-ethinylestradiol, 17beta-estradiol, estradiol valerate, piperazine estrone sulphate, estriol succinate, and polyestrol phosphate. Genistein is preferably at least 20 mg, and more preferably 50-80 mg. The progestin is selected from the group consisting of norgestimate in the range of 0.18-0.25 mg, levonorgestrel in the range of 0.05-0.3 mg, norgestrel in the range of 0.075-0.5 mg, norethindrone in the range of 0.5-1.0 mg, desogestrel in the range of 0.06-0.15 mg, gestodene in the range of 0.04-0.12 mg, dienogest in the range of 0.25-4.0 mg, drospirenone in the range of 0.25-4.0 mg, and medroxy-progesterone acetate in the range of 2.5-10 mg. The Vitamin D compound is preferably at a dosage of at least 400 IU.
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Citations
25 Claims
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1. A pharmaceutical product comprising multiple daily sequential dosages, said product comprising a progestin, genistein and an estrogen, said estrogen selected from the group consisting of estrone, estrone sulfate, estrone sulfate piperazine salt, estradiol and estriol, and their esters, mestranol, conjugated equine estrogen, esterified estrogens, estropipate, 17α
- -ethinylestradiol, esters and ethers of 17α
-ethinylestradiol, 17beta-estradiol, estradiol valerate, piperazine estrone sulphate, estriol succinate, and polyestrol phosphate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
- -ethinylestradiol, esters and ethers of 17α
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12. A pharmaceutical product comprising multiple daily sequential dosages, said product including 21 sequential daily hormone dosages, each hormone dosage comprising a progestin and an estrogen, said estrogen selected from the group consisting of estradiol and estriol, and their esters, mestranol, 17α
- -ethinylestradiol, esters and ethers of 17α
-ethinylestradiol, and 17beta-estradiol, and with at least one of said multiple daily sequential dosages including genistein at a dosage of at least 20 mg, and wherein said product is contraceptively effective. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 22, 23, 24, 25)
- -ethinylestradiol, esters and ethers of 17α
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21. A pharmaceutical product comprising multiple daily sequential dosages, said product including 21 sequential daily hormone dosages, each hormone dosage comprising an estrogen and optionally a progestin, said estrogen selected from said estrogen compound is selected from the group consisting of conjugated estrogens with a daily dosage in the range of 0.3-2.5 mg and estrified estrogens with a daily dosage in the range of 0.625-1.25 mg, and with at least one of said multiple daily sequential dosages including genistein at a dosage of at least 20 mg, and wherein said product is for hormone replacement therapy.
Specification