RAMIPRIL-AMINE SALTS

• US 20080167364A1
• Filed: 11/30/2007
• Published: 07/10/2008
• Est. Priority Date: 12/01/2006
• Status: Abandoned Application

• Current Assignee: Selamine Limited (Abbvie Incorporated)
• Original Assignee: Selamine Limited (Abbvie Incorporated)
• Inventors: O'Keeffe, Deirdre, Harrison, Paul Jonathan, Power, Anna Marie Elizabeth
• Application Number:
  US11/948,049
• Publication Number:
  US 20080167364A1
• Time in Patent Office: Days
• US Class Current: 514/412
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07D 209/52 condensed with a ring other than six-membered

Abstract

The present invention relates to ramipril-amine salts, such as, primary, secondary, tertiary and quaternary salts of ramipril.

Claims

1. A ramipril-amine salt.

2. The salt of claim 1, wherein the amine is ethanolamine, triethanolamine, erbumine, ammonia, triethylamine, meglumine, ethylamine diamine, choline, procaine or benzathine.

3. The salt of claim 1, having the formula X(NR¹R²R³), wherein X is ramipril and each of R¹, R² and R³ is independently selected from H, unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, or unsubstituted or substituted heterocycloalkyl

4. The salt of claim 1, having the formula X(NR¹R²R³R⁴) wherein X is ramipril and each of R¹, R², R³ and R⁴ is independently selected from H, unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, or unsubstituted or substituted heterocycloalkyl.

5. The salt of claim 1, wherein the amine is not dicyclohexylamine or meglumine.

6. The salt of claim 1, wherein the salt is substantially free or ramipril (free acid) or amine (free base).

7. The salt of claim 1, in crystalline form.

8. The salt of claim 1, in non-crystalline form.

9. A composition comprising a therapeutically effective amount of ramipril-amine salt and a pharmaceutically acceptable carrier.

10. The composition of claim 9, further comprising another therapeutic agent.

11. The composition of claim 10, wherein the other therapeutic agent is a diuretic, a statin, a calcium channel blocker, a statin, a calcium channel blocker, an antiinflammatory agent, an anti-renal failure agent, an anti-diabetic agent, an anti-cardiovascular disease agent, an opioid analgesic agent, a non-opioid analgesic agent, an antibiotic, an antiemetic, an anti fungal agent, an antidepressant, an immunomodulatory agent, a cytokine, a hormone, or a β

-interferon.

12. A method for treating a cardiovascular disorder comprising administering to a subject in need thereof a therapeutically effective amount of a ramipril-amine salt.

13. The method of claim 12, further comprising administering another therapeutic agent.

14. A method for treating an ischemic condition, comprising administering to a subject in need thereof a therapeutically effective amount of a ramipril-amine salt.

15. The method of claim 14, further comprising administering another therapeutic agent.

16. A method for treating renal failure, comprising administering to a subject in need thereof a therapeutically effective amount of a ramipril-amine salt.

17. The method of claim 16, further comprising administering another therapeutic agent.

18. A method for treating diabetes mellitus or a diabetic condition, comprising administering to a subject in need thereof a therapeutically effective amount of a ramipril-amine salt.

19. The method of claim 18, further comprising administering another therapeutic agent.

20. A method for reducing the incidence of recurrence or severity of a symptom of a cardiovascular disorder, an ischemic condition, renal failure, diabetes mellitus or a diabetic condition, comprising administering to a subject in need thereof a therapeutically effective amount of a ramipril-amine salt.

21. The method of claim 20, further comprising administering another therapeutic agent.