DETERMINATION OF TREATMENT RESULTS PRIOR TO TREATMENT OR AFTER FEW TREATMENT EVENTS
First Claim
1. A method of predicting response to a drug prior to drug administration comprising:
- obtaining a direct brain function measurement;
obtaining an indirect brain function measurement; and
,assessing the direct brain function measurement and the indirect brain function measurement collectively to obtain a drug response prediction,whereby the predictive value of the collective assessment is greater than a predictive value obtained from the separate predictive values for the direct and indirect measurements.
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Abstract
Disclosed are methods and data on determining response to a drug or other therapy prior to administration by obtaining a direct neurocognitive brain function measurement; obtaining an indirect neurocognitive brain function measurement; and, assessing the direct neurocognitive brain function measurement and the indirect neurocognitive brain function measurement collectively to obtain a response determination preferably the predictive value of the collective assessment is greater than a predictive value obtained from the separate predictive values for the direct and indirect measurements. Also disclosed are methods of determining dosage of a drug comprising administering a drug; comprising obtaining a direct neurocognitive brain function measurement; obtaining an indirect neurocognitive brain function measurement; and, assessing the direct neurocognitive brain function measurement and the indirect neurocognitive brain function measurement collectively to obtain a dosage, preferably the predictive value of the collective assessment is greater than a predictive value obtained from the separate predictive values for the direct and indirect measurements; optionally, additional cycles of obtaining and assessing indirect and direct measurements are performed.
85 Citations
16 Claims
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1. A method of predicting response to a drug prior to drug administration comprising:
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obtaining a direct brain function measurement; obtaining an indirect brain function measurement; and
,assessing the direct brain function measurement and the indirect brain function measurement collectively to obtain a drug response prediction, whereby the predictive value of the collective assessment is greater than a predictive value obtained from the separate predictive values for the direct and indirect measurements. - View Dependent Claims (2, 3, 4)
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5. A method of determining dosage of a drug with a linear dose-response curve, comprising steps of:
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administering a drug; obtaining a direct brain function measurement; obtaining an indirect brain function measurement; and
,assessing the direct brain function measurement and the indirect brain function measurement collectively to obtain a dosage prediction whereby the predictive value of the collective assessment is greater than a predictive value obtained from the separate predictive values for the direct and indirect measurements. - View Dependent Claims (6, 7, 8)
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9. A method of determining dosage of a drug with a nonlinear dose-response curve to achieve a specified response, comprising steps of:
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administering a first test dose of the drug; calculating a dose-response value for the test dose;
subsequently,administering a second test dose of the drug; calculating a dose-response value for the second test dose; calculating the slope between the responses to the two doses; extrapolating from the slope to a reach a specified response level; and
,identifying the dose that corresponds to that response level. - View Dependent Claims (10)
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11. A method of detecting mild cognitive impairment (“
- MCI”
), comprising steps of;obtaining a direct brain function measurement; obtaining an indirect brain function measurement; assessing the direct brain function measurement and the indirect brain function measurement collectively to obtain a prediction of the subject'"'"'s brain function whereby the predictive value of the collective assessment is greater than a predictive value obtained from the separate predictive values for the direct and indirect measurements. - View Dependent Claims (12, 13, 14, 15, 16)
- MCI”
Specification