Device for delivery of an agent to the eye and other sites
First Claim
Patent Images
1. A device for delivering an agent, the device adapted to have at least a portion positioned within a fluid-filled body part, the device comprisinga proximal portion having a reservoir adapted to contain an agent;
- an extension portion coupled to the proximal portion and adapted to be positioned within the body part containing fluid, the extension portion including an interior space for containing the agent and at least one aperture in an outer surface of the extension portion and in fluid communication with the interior space; and
an adjustable barrier juxtaposed between the reservoir of the proximal portion and the interior space of the extension portion, the barrier having at least one aperture for permitting fluid communication between the reservoir and the interior space, wherein the aperture is adapted to control the rate at which the agent enters the extension portion and thereafter equilibrates with the fluid in the body part.
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Abstract
A method and device for delivering an agent, such as an anti-vascular endothelial growth factor (VEGF) agent to ameliorate inflammation, at a site in the body that may be the eye, a joint, the brain, etc. The device located at the body site administers agent using an equilibrium diffusion process.
77 Citations
11 Claims
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1. A device for delivering an agent, the device adapted to have at least a portion positioned within a fluid-filled body part, the device comprising
a proximal portion having a reservoir adapted to contain an agent; -
an extension portion coupled to the proximal portion and adapted to be positioned within the body part containing fluid, the extension portion including an interior space for containing the agent and at least one aperture in an outer surface of the extension portion and in fluid communication with the interior space; and an adjustable barrier juxtaposed between the reservoir of the proximal portion and the interior space of the extension portion, the barrier having at least one aperture for permitting fluid communication between the reservoir and the interior space, wherein the aperture is adapted to control the rate at which the agent enters the extension portion and thereafter equilibrates with the fluid in the body part. - View Dependent Claims (2, 3, 4)
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5. An ocular device for delivering an agent the device comprising
a proximal portion having a reservoir adapted to contain an agent; -
an extension portion coupled to the proximal portion and adapted to be positioned within a vitreous cavity containing vitreous fluid, the extension portion including an interior space for containing the agent and at least one aperture in an outer surface of the extension portion and in fluid communication with the interior space; and an adjustable barrier juxtaposed between the reservoir of the proximal portion and the interior space of the extension portion, the barrier having at least one aperture for permitting fluid communication between the reservoir and the interior space, wherein the aperture is adapted to control the rate at which the agent enters the extension portion and thereafter equilibrates with vitreous fluid in the vitreous cavity. - View Dependent Claims (6, 7, 8)
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- 9. A method of ameliorating an ocular inflammatory process in a patient comprising providing to an eye of the patient a therapeutic concentration of at least one anti-vascular endothelial growth factor (VEGF) agent as the anti-inflammatory agent, the agent provided with a device to achieve a diffusion concentration of the anti-VEGF agent in the vitreous cavity at a concentration sufficient to ameliorate ocular inflammation.
Specification