NEUROSTIMULATION SYSTEM

• US 20080167698A1
• Filed: 03/19/2008
• Published: 07/10/2008
• Est. Priority Date: 09/08/2004
• Status: Active Grant

• Current Assignee: TC1 LLC (Abbott Laboratories), Board of Trustees of the Leland Stanford Junior University (Stanford University)
• Original Assignee: Spinal Modulation, Inc. (Abbott Laboratories)
• Inventors: Imran, Mir A., Kim, Daniel H.
• Granted Patent: US 8,712,546 B2
• Time in Patent Office: Days
• US Class Current: 607/48
• CPC Class Codes: A61M 2210/1003 Spinal column
• CPC Class Codes: A61M 25/06 Body-piercing guide needles or the like
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/0558 Anchoring or fixation means therefor
• CPC Class Codes: A61N 1/0568 with drug delivery
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36021 for treatment of pain
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 1/36171 Frequency

Abstract

Some embodiments of the present invention provide neurostimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide neurostimulation systems adapted for selective neurostimulation of one or more nerve root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.

Claims

1. A neurostimulation system, comprising:

a lead, wherein at least a portion of the lead is wrappable at least partially about a dorsal root ganglion so that an electrode on the lead is positioned to selectively stimulate the dorsal root ganglion;

a signal generator coupled to the electrode; and

a controller to control the output of the signal generator.

2. The neurostimulation system of claim 1 wherein the controller determines the output of the signal generator using a preset program.

3. The neurostimulation system according to claim 1 wherein the controller determines the output of the signal generator using a dynamic program selected based on an input.

4. The neurostimulation system according to claim 3 wherein the input is provided from a sensor monitoring a parameter in the body.

5. The neurostimulation system according to claim 3 where in the input is provided by a person being stimulated by the electrode.

6. The neurostimulation system according to claim 5 wherein the person being stimulated by the electrode provides the input by selecting from a plurality of predetermined programs selected by a physician.

7. The neurostimulation system according to claim 2 wherein one of the preset programs is no stimulation.

8. The neurostimulation system according to claim 3 wherein the input is provided by a physician.

9. The neurostimulation system according to claim 1 wherein the lead or the electrode further comprises a pharmacologically active coating.

10. The neurostimulation system according to claim 9 wherein the pharmacologically active coating comprises an anti-inflammatory agent.

11. The neurostimulation system according to claim 9 wherein a pharmacologically active coating comprises an opiate.

12. The neurostimulation system according to claim 9 wherein the pharmacologically active coating comprises a suitable pharmacological agent to prevent pathological pain changes after surgery.

13. The neurostimulation system according to claim 9 wherein the pharmacologically active coating comprises a COX inhibitor.

14. The neurostimulation system according to claim 9 wherein the pharmacologically active coating comprises a PGE2 inhibitor.

15. The neurostimulation system according to claim 1 wherein the electrode has an active electrode area of less than 10 mm².

16. The neurostimulation system according to claim 1 wherein the electrode has an active electrode area of less than 5 mm².

17. The neurostimulation system according to claim 4 wherein the sensor is an accelerometer coupled to the person being stimulated by the system.

18. The neurostimulation system according to claim 4 wherein the parameter of the body is the position of the body.