CARTILAGE REPAIR APPARATUS AND METHOD

• US 20080167716A1
• Filed: 03/21/2008
• Published: 07/10/2008
• Est. Priority Date: 07/16/2001
• Status: Abandoned Application

• Current Assignee: Hebert E. Schwartz, Mark J. Pelo, Pamela L. Plouhar, Prasanna Malaviya
• Original Assignee: Hebert E. Schwartz, Mark J. Pelo, Pamela L. Plouhar, Prasanna Malaviya
• Inventors: Schwartz, Hebert E., Malaviya, Prasanna, Plouhar, Pamela L., Pelo, Mark J.
• Application Number:
  US12/053,294
• Publication Number:
  US 20080167716A1
• Time in Patent Office: Days
• US Class Current: 623/11.11
• CPC Class Codes: A61B 2017/0641 having at least three legs as part of one single body
• CPC Class Codes: A61B 2017/0646 for insertion into cartillege, e.g. meniscus
• CPC Class Codes: A61B 2017/0647 having one single leg, e.g. tacks
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61F 2/0811 Fixation devices for tendons or ligaments
• CPC Class Codes: A61F 2/30749 Fixation appliances for connecting prostheses to the body
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2/3872 Meniscus for implantation between the natural bone surfaces
• CPC Class Codes: A61F 2002/30294 Conical or frustoconical body made by spirally rolling up a sheet or a strip around itself
• CPC Class Codes: A61F 2002/30299 umbrella-shaped or mushroom-shaped
• CPC Class Codes: A61F 2002/30579 with mechanically expandable devices, e.g. fixation devices
• CPC Class Codes: A61F 2002/30751 for attaching cartilage scaffolds to underlying bone
• CPC Class Codes: A61F 2002/30766 Scaffolds for cartilage ingrowth and regeneration
• CPC Class Codes: A61F 2230/0091 helically-coiled or spirally-coiled, i.e. having a 2-D spiral cross-section
• CPC Class Codes: A61F 2230/0093 Umbrella-shaped, e.g. mushroom-shaped
• CPC Class Codes: A61L 2430/06 for cartilage reconstruction, e.g. meniscus
• CPC Class Codes: A61L 27/3629 Intestinal tissue, e.g. small intestinal submucosa
• CPC Class Codes: A61L 27/3633 Extracellular matrix [ECM]
• CPC Class Codes: A61L 27/3654 Cartilage, e.g. meniscus
• CPC Class Codes: A61L 27/3683 subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
• CPC Class Codes: A61L 27/3804 : characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
• CPC Class Codes: A61L 27/3852 : Cartilage, e.g. meniscus
• CPC Class Codes: A61L 27/3886 : comprising two or more cell types
• CPC Class Codes: A61P 19/00 : Drugs for skeletal disorders

Abstract

An orthopaedic device for repairing and regenerating cartilage includes a plug configured to be positioned in a hole formed in the cartilage and an anchor configured to support the plug. One or both of the plug and the anchor may be formed from naturally occurring extracellular matrix such as small intestine submucosa. A method for repairing and regenerating cartilage is also disclosed.

Claims

1. A device for repairing a diseased or damaged portion of articular cartilage on a bone of a joint, the cartilage having been prepared by forming an opening therein to remove the diseased or damaged portion, the device comprising:

a plug configured to be positioned in the opening formed in the cartilage, the plug defining a body of unseeded naturally occurring extracellular matrix, and

an anchor configured to position and hold the plug in the opening.

2. The device of claim 1, wherein the naturally occurring extracellular matrix comprises comminuted naturally occurring extracellular matrix.

3. The device of claim 2, wherein the comminuted naturally occurring extracellular matrix is lyophilized.

4. The device of claim 1, wherein the naturally occurring extracellular matrix comprises tissue selected from the group consisting of:

vertebrate small intestine submucosa;

vertebrate liver basement membrane;

vertebrate bladder submucosa;

vertebrate stomach submucosa;

vertebrate alimentary tissue;

vertebrate respiratory tissue; and

vertebrate genital tissue.

5. The device of claim 4, wherein the naturally occurring extracellular matrix comprises tissue selected from the group consisting of:

bovine tissue;

ovine tissue; and

porcine tissue.

6. The device of claim 1, wherein the anchor is formed of naturally occurring extracellular matrix cured and shaped to fasten into a subchondral portion of the bone.

7. The device of claim 6, wherein the anchor comprises (i) a head portion configured to support the plug, and (ii) a body portion extending from the head portion to fasten into the subchondral portion of the bone.

8. The device of claim 1, further comprising a cover disposed over at least part of an articular surface of the plug, wherein the cover comprises one or more sheets of naturally occurring extracellular matrix.

9. A device for repairing a diseased or damaged portion of articular cartilage on a bone of a joint, the cartilage having been prepared by forming an opening therein to remove the diseased or damaged portion, the device comprising:

a plug configured to be positioned in the opening formed in the cartilage, the plug defining a body of naturally occurring extracellular matrix seeded with at least one of the following;

a bioactive agent, a biologically derived substance, cells, a biological lubricant, a biocompatible polymer and a biocompatible inorganic material, and

an anchor configured to position and hold the plug in the opening.

10. The device of claim 9, wherein the naturally occurring extracellular matrix comprises comminuted naturally occurring extracellular matrix.

11. The device of claim 10, wherein the comminuted naturally occurring extracellular matrix is lyophilized.

12. The device of claim 9, wherein the naturally occurring extracellular matrix comprises tissue selected from the group consisting of:

vertebrate small intestine submucosa;

vertebrate liver basement membrane;

vertebrate bladder submucosa;

vertebrate stomach submucosa;

vertebrate alimentary tissue;

vertebrate respiratory tissue; and

vertebrate genital tissue.

13. The device of claim 12, wherein the naturally occurring extracellular matrix comprises tissue selected from the group consisting of:

bovine tissue;

ovine tissue; and

porcine tissue.

14. The device of claim 9, wherein the anchor is formed of naturally occurring extracellular matrix cured and shaped to fasten into a subchondral portion of the bone.

15. The device of claim 14, wherein the anchor comprises (i) a head portion configured to support the plug, and (ii) a body portion extending from the head portion to fasten into the subchondral portion of the bone.

16. The device of claim 9, further comprising a cover disposed over at least part of an articular surface of the plug, wherein the cover comprises one or more sheets of naturally occurring extracellular matrix.

17. A device for repairing a diseased or damaged portion of articular cartilage on a bone of a joint, the cartilage having been prepared by forming an opening therein to remove the diseased or damaged portion, the device comprising:

a plug configured to be positioned in the opening formed in the cartilage, wherein (i) the plug comprises naturally occurring extracellular matrix, and (ii) the plug has an outer articular surface and one or more side surfaces extending therefrom,

an anchor configured to position and hold the plug in the opening, and

a cover disposed over at least part of the articular surface of the plug, wherein the cover comprises one or more sheets of naturally occurring extracellular matrix.

18. The device of claim 17, wherein the naturally occurring extracellular matrix comprises comminuted naturally occurring extracellular matrix.

19. The device of claim 17, wherein the comminuted naturally occurring extracellular matrix is lyophilized.

20. The device of claim 17, wherein the naturally occurring extracellular matrix comprises tissue selected from the group consisting of:

vertebrate small intestine submucosa;

vertebrate liver basement membrane;

vertebrate bladder submucosa;

vertebrate stomach submucosa;

vertebrate alimentary tissue;

vertebrate respiratory tissue; and

vertebrate genital tissue.

21. The device of claim 20, wherein the naturally occurring extracellular matrix comprises tissue selected from the group consisting of:

bovine tissue;

ovine tissue; and

porcine tissue.

22. The device of claim 17, wherein the anchor is formed of naturally occurring extracellular matrix cured and shaped to fasten into a subchondral portion of the bone.

23. The device of claim 22, wherein the anchor comprises (i) a head portion configured to support the plug, and (ii) a body portion extending from the head portion to fasten into the subchondral portion of the bone.