METHOD AND SYSTEM FOR GLEASON SCALE PATTERN RECOGNITION
First Claim
Patent Images
1. A method for classifying pixels of a pixel image representing a substance into one of multiple classes, comprising:
- providing a maximum likelihood estimation model for each of a plurality of cancer conditions, each model having a first gradient probability distribution parameter, a cancerous region area parameter, a significant gradient magnitude distribution parameter, and a gradient phase distribution;
providing a pixel array representing a tissue having a cancer;
generating an array of gradient values, each value having a gradient magnitude and a gradient angle, each value corresponding to a pixel array;
generating an array of local maxima gradients, each corresponding to one value of the array of gradient values, and each indicating a magnitude of a pixel of the pixel array having a relative magnitude larger than a neighbor pixel;
generating a first gradient probability distribution function, based on a cancerous tissue, and based on said teacher basis;
generating an array of significant gradients, based on the array of gradient values and on a given low threshold and a given high threshold;
generating a phase distribution, representing a probability distribution of the gradient angle of said array of significant gradients;
generating a significant gradient probability distribution function characterizing a probability distribution of the magnitude of the significant gradients;
performing a maximum likelihood estimate, based on said first gradient, said probability distribution function, said first gradient probability distribution said cancerous tissue area value, and said phase distribution, to maximize the probability of the subject pixel being in one, and not all, classification.
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Abstract
A gradient is calculated for a pixel image representing a cancer area, the gradient having magnitude and direction. Local extrema of the gradients are identified, remaining pixels are zeroed. Significant gradients among the local extrema are identified, based on thresholds obtained through training. Probability distributions are calculated for the local extrema magnitudes and the significant gradient magnitudes, to form a feature vector. The feature vector is classified using a Maximum Likelihood Estimate classifier constructed from large training sets.
14 Citations
14 Claims
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1. A method for classifying pixels of a pixel image representing a substance into one of multiple classes, comprising:
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providing a maximum likelihood estimation model for each of a plurality of cancer conditions, each model having a first gradient probability distribution parameter, a cancerous region area parameter, a significant gradient magnitude distribution parameter, and a gradient phase distribution; providing a pixel array representing a tissue having a cancer; generating an array of gradient values, each value having a gradient magnitude and a gradient angle, each value corresponding to a pixel array; generating an array of local maxima gradients, each corresponding to one value of the array of gradient values, and each indicating a magnitude of a pixel of the pixel array having a relative magnitude larger than a neighbor pixel; generating a first gradient probability distribution function, based on a cancerous tissue, and based on said teacher basis; generating an array of significant gradients, based on the array of gradient values and on a given low threshold and a given high threshold; generating a phase distribution, representing a probability distribution of the gradient angle of said array of significant gradients; generating a significant gradient probability distribution function characterizing a probability distribution of the magnitude of the significant gradients; performing a maximum likelihood estimate, based on said first gradient, said probability distribution function, said first gradient probability distribution said cancerous tissue area value, and said phase distribution, to maximize the probability of the subject pixel being in one, and not all, classification. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A machine-readable storage medium to provide instructions, which if executed on the machine performs operations comprising:
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providing a maximum likelihood estimation model for each of a plurality of cancer conditions, each model having a first gradient probability distribution parameter, a cancerous region area parameter, a significant gradient magnitude distribution parameter, and a gradient phase distribution; providing a pixel array representing a tissue having a cancer; generating an array of gradient values, each value having a gradient magnitude and a gradient angle, each value corresponding to a pixel array; generating an array of local maxima gradients, each corresponding to one value of the array of gradient values, and each indicating a magnitude of a pixel of the pixel array having a relative magnitude larger than a neighbor pixel; generating a first gradient probability distribution function, based on a cancerous tissue, and based on said teacher basis; generating an array of significant gradients, based on the array of gradient values and on a given low threshold and a given high threshold; generating a phase distribution, representing a probability distribution of the gradient angle of said array of significant gradients; generating a significant gradient probability distribution function characterizing a probability distribution of the magnitude of the significant gradients; performing a maximum likelihood estimate, based on said first gradient, said probability distribution function, said first gradient probability distribution said cancerous tissue area value, and said phase distribution, to maximize the probability of the subject pixel being in one, and not all, classification. - View Dependent Claims (8, 9, 10, 11, 12)
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13. An ultrasound image recognition system comprising:
- an ultrasound scanner having an RF echo output, an analog to digital (A/D) frame sampler for receiving the RF echo output, a machine arranged for executing machine-readable instructions, and a machine-readable storage medium to provide instructions, which if executed on the machine, perform operations comprising;
providing a maximum likelihood estimation model for each of a plurality of cancer conditions, each model having a first gradient probability distribution parameter, a cancerous region area parameter, a significant gradient magnitude distribution parameter, and a gradient phase distribution; providing a pixel array representing a tissue having a cancer; generating an array of gradient values, each value having a gradient magnitude and a gradient angle, each value corresponding to a pixel array; generating an array of local maxima gradients, each corresponding to one value of the array of gradient values, and each indicating a magnitude of a pixel of the pixel array having a relative magnitude larger than a neighbor pixel; generating a first gradient probability distribution function, based on a cancerous tissue, and based on said teacher basis; generating an array of significant gradients, based on the array of gradient values and on a given low threshold and a given high threshold; generating a phase distribution, representing a probability distribution of the gradient angle of said array of significant gradients; generating a significant gradient probability distribution function characterizing a probability distribution of the magnitude of the significant gradients; performing a maximum likelihood estimate, based on said first gradient, said probability distribution function, said first gradient probability distribution said cancerous tissue area value, and said phase distribution, to maximize the probability of the subject pixel being in one, and not all, classification. - View Dependent Claims (14)
- an ultrasound scanner having an RF echo output, an analog to digital (A/D) frame sampler for receiving the RF echo output, a machine arranged for executing machine-readable instructions, and a machine-readable storage medium to provide instructions, which if executed on the machine, perform operations comprising;
Specification