THYMIDINE ANALOGS FOR IMAGING
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention relates to nucleoside analogues and more particularly to labeled nucleoside analogues. It has been found new thymidine analogues can be stably labeled with a detectable label moiety. Further the present invention relates to methods of making above compounds and use of such compounds for diagnostic imaging of tumor cells and/or treatment of proliferative diseases. In addition, the present invention relates to the preparation and use of positron emitting compounds for positron emission tomography (PET). A kit is also disclosed.
-
Citations
38 Claims
- 1. A compound according to formula (I)
-
34. A kit comprising
iv. compound of formula I; -
v. compound of formula II; vi. compound of formula III or vii. compound of formula IV and V. - View Dependent Claims (35)
-
-
36. A method for diagnosing tissue proliferations, hyperplastic inflammation, benign tumours or malignant tumours comprising the steps of
a) administering to a patient a compound of formula I, and b) measuring positron emission by PET.
-
38. Compound selected from
N3-(3-(N-(4-[19F]-fluorobenzoyl))amino-propyl)-O,O-bis-(1′ - -methoxy-1′
-cyclohexyl) thymidine 12,N3-(3-(N-(4-[19F]-fluorobenzoyl))amino-propyl)-thymidine 13, N3-(3-(N-(3-cyano-4-[19F]-fluorobenzoyl))amino-propyl)-O,O-bis-(1′
-methoxy-1′
-cyclohexyl) thymidine 12a,N3-(3-(N-(3-trifluoromethyl-4-[19F]-fluorobenzoyl))amino-propyl)-O,O-bis-(1′
-methoxy-1′
-cyclohexyl) thymidine 12b,N3-(3-(N-(2-chloro-4-[19F]-fluorobenzoyl))amino-propyl)-O,O-bis-(1′
-methoxy-1′
-cyclohexyl) thymidine 12c,N3-(3-(N-(3-cyano-4-[19F]-fluorobenzoyl))amino-propyl)-thymidine 13a, N3-(3-(N-(4-[19F]-fluoro-3-trifluormethyl-benzoyl))amino-propyl)-thymidine 13b, N3-(3-(N-(2-chloro-4-[19F]-fluorobenzoyl))amino-propyl)-thymidine 13c, 3-(4-[19F]-Fluorobutyl)-thymidine 18, 3-(6-[19F]-Fluorohexyl)-thymidine 19, 3-(4-[18F]-Fluorobutyl)-thymidine 14, and 3-(6-[18F]-Fluorohexyl)-thymidine 17.
- -methoxy-1′
Specification