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Practical computer program that diagnoses diseases in actual patients

  • US 20080171916A1
  • Filed: 03/13/2008
  • Published: 07/17/2008
  • Est. Priority Date: 05/20/2005
  • Status: Abandoned Application
First Claim
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1. A medical diagnostic algorithm excluding disease prevalence and subjective qualities of clinical data, said algorithm comprising the steps of:

  • a) computing for each clinical datum a sensitivity S based on disease cases to derive sensitivities as follows;

    S = number



    of



    disease



    cases
    manifesting



    said



    clinical



    datum
    total



    number



    of



    diseases



    cases
    ;

    b) computing for each clinical datum present a positive predictive value PP valuei supporting a disease diagnosis i, thereby obtaining PP value1 through PP valuen;

    PP



    value i
    = S i S 1 +

    + S i +

    + S n
    ,
    where Si denotes sensitivity of said clinical datum present for said disease diagnosis i and S1 . . . Sn denote sensitivities of said clinical datum for corresponding disease diagnoses 1 . . . n;

    c) storing said sensitivities and said positive predictive values in a database linked to each said clinical datum and to a corresponding disease model;

    d) ruling in disease diagnoses into a differential diagnosis list when clinical data present in a patient match at least one clinical datum present for said corresponding disease model;

    e) establishing a cost of collecting a clinical datum not yet investigated in said patient, said cost of collecting being the maximum value of expense, risk and discomfort to said patient;


    Cost=max(expense,risk,discomfort);

    f) establishing a benefit of collecting said clinical datum not yet investigated in said patient based on its impact on a probability P of at least one of said disease diagnoses in said differential diagnosis list;

    wherein said clinical datum not yet investigated is chosen for investigation in said patient in an analysis comprising a best cost-benefit consideration of said cost of collecting and said benefit of collecting.

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