Integrated System for Collecting, Processing and Transplanting Cell Subsets, Including Adult Stem Cells, for Regenerative Medicine
First Claim
1. A system for the extraction, collection, processing and transplantation of cell subsets, including adult stem cells and platelets, in particular for organ repair in regenerative medicine, the system comprising a set of disposable sterile fluid-transport elements that are pre-connected or that include aseptic connectors or are adapted for making interconnections between them in an aseptic manner, the set including:
- an extracting device, for example including a needle for bone or vein puncture, for extracting bone marrow or other sources of cell subsets from a patient;
at least one chamber for the collection, processing and reinfusion of the cell subsets extracted from the patient, including a collection chamber pre-connected or connectable to the extracting device for harvesting the cells extracted from the patient by the extracting device;
a processing chamber adapted to cooperate with processing equipment to perform processing and transfer operations on the harvested cells; and
a reinfusion chamber for storing processed cells to be delivered back to the patient;
wherein the collection, processing and reinfusion chambers are separate and are pre-connected or interconnectable, or wherein a multi-purpose processing chamber provides the combined functions of a collection-processing chamber, a processing-reinfusion chamber or a collection-processing-reinfusion chamber; and
a transplantation device pre-connected or connectable to the reinfusion chamber for delivering processed cells back to the patient.
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Accused Products
Abstract
A system for the extraction, collection, processing and transplantation of cell subsets, including adult stem cells and platelets, in particular for tissue repair in regenerative medicine, comprises a set of disposable fluid-transport elements that are pre-connected or that include aseptic connectors for making interconnections between them in an aseptic manner or are adapted to be aseptically connected. The set usually includes three kits of disposable sterile elements, a collection kit, a processing kit, and a transplantation kit packaged in a blister pack on a support such as a tray, having one compartment for receiving each inter-connectable kit of the set. The set includes an extracting device, for example including a needle for bone puncture or vein puncture, for extracting bone marrow or other sources of cell subsets from a patient.
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Citations
19 Claims
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1. A system for the extraction, collection, processing and transplantation of cell subsets, including adult stem cells and platelets, in particular for organ repair in regenerative medicine, the system comprising a set of disposable sterile fluid-transport elements that are pre-connected or that include aseptic connectors or are adapted for making interconnections between them in an aseptic manner, the set including:
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an extracting device, for example including a needle for bone or vein puncture, for extracting bone marrow or other sources of cell subsets from a patient; at least one chamber for the collection, processing and reinfusion of the cell subsets extracted from the patient, including a collection chamber pre-connected or connectable to the extracting device for harvesting the cells extracted from the patient by the extracting device;
a processing chamber adapted to cooperate with processing equipment to perform processing and transfer operations on the harvested cells; and
a reinfusion chamber for storing processed cells to be delivered back to the patient;
wherein the collection, processing and reinfusion chambers are separate and are pre-connected or interconnectable, or wherein a multi-purpose processing chamber provides the combined functions of a collection-processing chamber, a processing-reinfusion chamber or a collection-processing-reinfusion chamber; anda transplantation device pre-connected or connectable to the reinfusion chamber for delivering processed cells back to the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 18)
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17. A method of collecting and processing a cell subset extracted from a human being for transplantation into the human being in particular for organ repair in regenerative medicine, comprising collecting the extracted cells in a collection chamber connected to an extraction device through which the cells in particular bone marrow containing stem cells are extracted, processing the cells in a centrifugal processing chamber which is the same as the collection chamber or which is connected to the collection chamber, and collecting the processed cells in a reinfusion chamber which is the same as the processing chamber or is connected to the processing chamber, the reinfusion chamber being connected to a transplantation device connected to the reinfusion chamber for delivering processed cell subset(s) back to the patient.
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19. An optical sensor which is able to measure absorption and reflection of a cell subset passing through a transparent tubing.
Specification