SENSORS FOR DETECTING SUBSTANCES INDICATIVE OF STROKE, ISCHEMIA, INFECTION OR INFLAMMATION
First Claim
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1. A system for measuring nitric oxide or one of its metabolic products comprising:
- a fluid flow path extending between an end adapted for receiving a sample of bodily fluid and a reaction chamber;
a filter in the flow path;
a first pump for advancing the sample through the filter to produce a filtrate;
a second pump for advancing filtrate into the reaction chamber;
a third pump for advancing reactant into the reaction chamber; and
a sensor in communication with the reaction chamber for determining a concentration of nitric oxide or one of its metabolic products.
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Abstract
A system is disclosed that extracts bodily fluid to a reaction chamber for monitoring a substance or property of the patient fluid. In one embodiment, a pump is used to advance the sample of bodily fluid through a filter to produce a filtrate. Another pump advances filtrate into the reaction chamber, while another pump advances reactant into the reaction chamber. A sensor in communication with the reaction chamber determines a concentration of nitric oxide or one of its metabolic products. Methods are also disclosed.
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Citations
20 Claims
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1. A system for measuring nitric oxide or one of its metabolic products comprising:
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a fluid flow path extending between an end adapted for receiving a sample of bodily fluid and a reaction chamber; a filter in the flow path; a first pump for advancing the sample through the filter to produce a filtrate; a second pump for advancing filtrate into the reaction chamber; a third pump for advancing reactant into the reaction chamber; and a sensor in communication with the reaction chamber for determining a concentration of nitric oxide or one of its metabolic products. - View Dependent Claims (2, 3, 4, 5)
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6. A system for measuring nitric oxide or one of its metabolic products:
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a fluid flow path extending between an end adapted for receiving a sample of bodily fluid and a reaction chamber; a filter in the flow path; a first pump for advancing the sample through the filter to produce a filtrate; a first reactant reservoir and a second reactant reservoir in communication with the reaction chamber; a second pump for advancing a mixture from the first and second reactant reservoirs and the filtrate into the reaction chamber; and a sensor in communication with the reaction chamber for determining a concentration of nitric oxide or one of its metabolic products. - View Dependent Claims (7, 8, 9, 10)
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11. A method of measuring a level of nitric oxide or one of its metabolic products in bodily fluid, comprising the steps of:
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directing a stream of bodily fluid through a filter to produce a filtrate; directing the filtrate into a reaction chamber; providing a reactant; directing the reactant into the reaction chamber to react with the filtrate to produce a reaction product; and measuring a concentration of nitric oxide or one of its metabolic products in the reaction product. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification