VOLUMETRIC IMAGE FORMATION FROM OPTICAL SCANS OF BIOLOGICAL TISSUE WITH MULTIPLE APPLICATIONS INCLUDING DEEP BRAIN OXYGENATION LEVEL MONITORING
First Claim
1. A method for non-invasive monitoring of a biological volume, comprising:
- causing each of a plurality of optical sources and a plurality of optical detectors to be positioned in optical coupling with the biological volume, each of the plurality of optical sources defining a source-detector pair with each of the plurality of optical detectors;
causing the plurality of optical sources to emit optical radiation into the biological volume at substantially non-overlapping time intervals, and causing each optical detector to detect optical radiation impinging thereupon from the biological volume, whereby at least one optical measurement is acquired for each source-detector pair;
for each source-detector pair, processing the at least one optical measurement to compute a requisite property value associated therewith, said processing including accounting for weighting a volumetric basis region corresponding to that source-detector pair by said requisite property value, said volumetric basis region being representative of an estimated subvolume of the biological volume encountered by optical radiation emitted from that source and propagating to that detector, and said processing further accounting for accumulating the weighted volumetric basis regions into a volumetric cumulative array; and
generating a display output based at least in part on said volumetric cumulative array.
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Accused Products
Abstract
Methods, systems, and related computer program products for non-invasive monitoring of a biological volume, such as a human brain, are described. In one preferred embodiment, each of a plurality of optical sources emits optical radiation into the biological volume each of a plurality of optical detectors detects optical radiation impinging thereupon from the biological volume. The optical measurements are processed to compute a requisite property value associated with each source-detector pair. For each source-detector pair, a volumetric basis region corresponding thereto is weighted by the requisite property value, the volumetric basis region being predetermined and representative of an estimated subvolume of the biological volume encountered by optical radiation emitted from that source and propagating to that detector. The weighted volumetric basis regions are accumulated into a volumetric cumulative array, and a display output is generated based at least in part on the volumetric cumulative array.
75 Citations
23 Claims
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1. A method for non-invasive monitoring of a biological volume, comprising:
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causing each of a plurality of optical sources and a plurality of optical detectors to be positioned in optical coupling with the biological volume, each of the plurality of optical sources defining a source-detector pair with each of the plurality of optical detectors; causing the plurality of optical sources to emit optical radiation into the biological volume at substantially non-overlapping time intervals, and causing each optical detector to detect optical radiation impinging thereupon from the biological volume, whereby at least one optical measurement is acquired for each source-detector pair; for each source-detector pair, processing the at least one optical measurement to compute a requisite property value associated therewith, said processing including accounting for weighting a volumetric basis region corresponding to that source-detector pair by said requisite property value, said volumetric basis region being representative of an estimated subvolume of the biological volume encountered by optical radiation emitted from that source and propagating to that detector, and said processing further accounting for accumulating the weighted volumetric basis regions into a volumetric cumulative array; and generating a display output based at least in part on said volumetric cumulative array. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 23)
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13. A method for facilitating non-invasive monitoring of a biological volume, comprising:
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receiving first information representative of optical measurements acquired from a plurality of optical source-detector pairs positioned in optical coupling with the biological volume; processing said first information to compute second information representative of a requisite property value for each source-detector pair; and processing said second information to compute third information representative of a three-dimensional map of the requisite property value, wherein said processing said second information to compute said third information comprises; receiving, for each optical source-detector pair, predetermined fourth information representative of a volumetric basis region corresponding to that source-detector pair, said volumetric basis region being representative of an estimated subvolume of the biological volume encountered by optical radiation emitted from that source and propagating to that detector; for each optical source-detector pair, weighting the corresponding volumetric basis region according to the requisite property value for that source-detector pair; and computing a voxelwise sum of all of said weighted volumetric basis regions to generate said third information representative of the three-dimensional map of the requisite property value. - View Dependent Claims (14, 15, 16, 17)
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18. A computer program product tangibly stored on a computer-readable medium for facilitating non-invasive monitoring of a biological volume, comprising:
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computer code for receiving first information representative of optical measurements acquired from a plurality of optical source-detector pairs optically coupled with the biological volume; computer code for processing said first information to compute second information representative of a requisite property value for each source-detector pair; and computer code for processing said second information to compute third information representative of a three-dimensional map of the requisite property value, wherein said computer code for processing said second information to compute said third information comprises; computer code for receiving, for each optical source-detector pair, predetermined fourth information representative of a volumetric basis region corresponding to that source-detector pair, said volumetric basis region being representative of an estimated subvolume of the biological volume encountered by optical radiation emitted from that source and propagating to that detector; computer code for weighting, for each optical source-detector pair, the corresponding volumetric basis region according to the requisite property value for that source-detector pair; and computer code for computing a voxelwise sum of all of said weighted volumetric basis regions to generate said third information representative of the three-dimensional map of the requisite property value. - View Dependent Claims (19, 20)
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21. A computer program product tangibly stored on a computer-readable medium for facilitating non-invasive monitoring of a biological volume, comprising:
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computer code for receiving first information representative of optical measurements acquired from a plurality of optical source-detector pairs optically coupled with the biological volume; computer code for processing said first information to compute second information representative of a requisite property value for each source-detector pair; computer code for processing said second information to compute third information representative of a three-dimensional map of the requisite property value, wherein said computer code for processing said second information to compute said third information comprises computer code for reconstructing an image representative of said three-dimensional map, said reconstructing accounting for volumetric basis regions related to the source-detector pairs, said volumetric basis regions being representative of estimated subvolumes of the biological volume encountered by optical radiation emitted from the sources and propagating to the detectors; and computer code for further processing said third information to cause a selected two-dimensional or three-dimensional display of display information derived at least in part from said third information. - View Dependent Claims (22)
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Specification