Ultrasensitive amperometric saliva glucose sensor strip
First Claim
1. An apparatus for detecting a concentration of glucose in a biological sample other than blood, comprising:
- a support member;
an electrode disposed on the support member having an exposed surface area;
a sample region comprising a sample port upon which the biological sample is applied;
a lumen having a proximal end in fluid communication with the sample region; and
a measurement zone in fluid communication with a distal end of the lumen, the measurement zone having an enzymatic catalyst, the measurement zone providing a minimum sensitivity of at least about 50 micromolar glucose concentration and a noise level of less than about 0.5 nA/μ
M/mm2.
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Abstract
Methods and apparatus for measuring a carbohydrate in a fluid are presented. An amperometric glucose sensor system suitable for glucose monitoring in a biological sample other than blood includes a support member having a sample region defined thereon in fluid communication with a measurement zone including an electrode having an exposed surface area. Biological sample fluid is transported from the sample region to the measurement zone, which includes an exposed catalyst in communication with the electrode providing a minimum sensitivity of at least about 50 micromolar glucose concentration and a noise level of less than about 0.5 nA/μM/mm2. In some embodiments, at least one of a nanofiltration material and a porous absorbent material is provided between the sample region and the measurement zone.
25 Citations
34 Claims
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1. An apparatus for detecting a concentration of glucose in a biological sample other than blood, comprising:
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a support member; an electrode disposed on the support member having an exposed surface area; a sample region comprising a sample port upon which the biological sample is applied; a lumen having a proximal end in fluid communication with the sample region; and a measurement zone in fluid communication with a distal end of the lumen, the measurement zone having an enzymatic catalyst, the measurement zone providing a minimum sensitivity of at least about 50 micromolar glucose concentration and a noise level of less than about 0.5 nA/μ
M/mm2. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. An apparatus for processing a mammalian saliva sample comprising:
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a saliva sample port for receiving the saliva sample; and a filter in fluid communication with the sample port, the filter including; a nanofiltration material configured to remove high molecular weight contaminants from the saliva sample; and a porous absorbent material configured to absorb at least a portion of the saliva sample, wherein the saliva sample is filtered by the nanofiltration material and the absorbent material. - View Dependent Claims (21, 22, 23, 24, 25, 26)
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27. A method for determining glucose levels in a mammalian saliva sample comprising:
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receiving the saliva sample at a sample port; transporting at least a portion of the received saliva sample from the sample port to a measurement zone; combining the transported saliva sample with an enzymatic catalyst within the measurement zone; measuring a glucose level of the saliva sample with a minimum sensitivity of at least about 50 micromolar glucose concentration and a noise level of less than about 0.5 nA/μ
M/mm2. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34)
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Specification