HEART ATTACK DETECTOR

• US 20080177194A1
• Filed: 01/19/2007
• Published: 07/24/2008
• Est. Priority Date: 01/19/2007
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Baynham, Tamara Colette, Patangay, Abhilash, Zhang, Yi, Thompson, Julie, Manicka, Yatheendhar D., Fogoros, Richard, KenKnight, Bruce H., Mazar, Scott T., Pederson, Michael J.
• Granted Patent: US 8,014,863 B2
• Time in Patent Office: Days
• US Class Current: 600/513
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/358 Detecting ST segments
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 7/00 Instruments for auscultation
• CPC Class Codes: A61B 7/023 for introduction into the body, e.g. into the oesophagus oesophageal ECG probes A61B5/285
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/3655 controlled by body or blood temperature
• CPC Class Codes: A61N 1/36557 controlled by chemical substances in blood
• CPC Class Codes: A61N 1/36564 controlled by blood pressure
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

A system including an implantable trigger event detector and an implantable ischemia detector. The implantable trigger event detector is adapted to detect at least one first condition and to output a responsive trigger signal including information about whether the first condition has been detected. The implantable ischemia detector is adapted to detect a second condition indicative of one or more physiologic cardiovascular events in a subject that are indicative of ischemia. The ischemia detector is coupled to the trigger event detector to receive the trigger signal, and the ischemia detector is enabled upon the trigger signal indicating that the first condition has been detected.

Claims

1. A system comprising:

an implantable trigger event detector, adapted to detect at least one first condition and to output a responsive trigger signal including information about whether the first condition has been detected; and

an implantable ischemia detector, adapted to detect a second condition indicative of one or more physiologic cardiovascular events in a subject that are indicative of ischemia, wherein the ischemia detector is coupled to the trigger event detector to receive the trigger signal, and wherein the ischemia detector is enabled upon the trigger signal indicating that the first condition has been detected.

2. The system of claim 1, further including an implantable cardiac signal sensing circuit in communication with the trigger event detector, and wherein the ischemia detector is enabled upon the trigger signal indicating that a heart rate exceeds a predetermined heart rate threshold value.

3. The system of claim 1, further including an implantable cardiac signal sensing circuit in communication with the trigger event detector, and wherein the ischemia detector is enabled upon the trigger signal indicating that a rate of change in heart rate exceeds a predetermined heart rate threshold value.

4. The system of claim 1, further including an implantable cardiac signal sensing circuit in communication with the trigger event detector, and wherein the ischemia detector is enabled upon the trigger signal indicating a decrease in heart rate variability (HRV).

5. The system of claim 1, further including an implantable cardiac signal sensing circuit and an implantable respiration sensor in communication with the trigger event detector, and wherein the ischemia detector is enabled upon the trigger signal indicating a decrease in respiratory sinus arrhythmia (RSA).

6. The system of claim 1, further including an implantable patient activity sensor and a timer circuit coupled to the trigger event detector, and wherein the ischemia detector is enabled upon the trigger signal indicating a decrease in patient activity level within a predetermined period of time.

7. The system of claim 1, further including an implantable patient activity sensor and an implantable respiration sensor in communication with the trigger event detector, and wherein the ischemia detector is enabled upon the trigger signal indicating at least one of an increase in patient exertion and an increase in patient stress.

8. The system of claim 1, further including an implantable cardiac signal sensing circuit in communication with the trigger event detector, and wherein the ischemia detector is enabled upon the trigger signal indicating an abnormal cardiac rhythm.

9. The system of claim 1, further including a timer circuit coupled to the trigger event detector, and wherein the ischemia detector is enabled by the trigger event detector using a circadian rhythm.

10. The system of claim 1, wherein the trigger event detector and the ischemia detector are included in an implantable medical device (IMD), wherein the system further includes an external device adapted to communicate with the IMD, and wherein the ischemia detector is enabled by the trigger event detector in response to a communication with the external device.

11. The system of claim 1, wherein the ischemia detector includes one or more implantable sensors from the group consisting of:

a) a heart sound sensor;

b) a cardiac blood pressure sensor;

c) a cardiac signal sensing circuit adapted to sense intracardiac electrograms;

d) a subcutaneous ECG sensing circuit;

e) a cardiac wall motion sensor;

f) a transthoracic impedance sensor;

g) an intracardiac impedance sensor;

h) a chemical sensor;

i) an oxygen sensor;

j) an accelerometer; and

k) a temperature sensor.

12. The system of claim 1, wherein the ischemia detector includes:

at least one first implantable sensor, configured to produce a first electrical sensor signal related to one or more physiologic cardiovascular events in a subject that are indicative of ischemia; and

an implantable posture sensor configured to produce an electrical signal related to posture of the subject, and wherein the ischemia detector is configured to trend the first electrical sensor signal in relation to posture of the subject.

13. The system of claim 1, wherein the ischemia detector includes:

at least one first implantable sensor, configured to produce a first electrical sensor signal related to one or more physiologic cardiovascular events in a subject that are indicative of ischemia; and

an implantable activity sensor configured to produce an electrical signal related to activity of the subject, wherein the ischemia detector is configured to trend the first electrical sensor signal in relation to activity of the subject.

14. The system of claim 1, wherein the ischemia detector includes:

at least one first implantable sensor, configured to produce a first electrical sensor signal related to one or more physiologic cardiovascular events in a subject that are indicative of ischemia; and

an implantable cardiac signal sensing circuit configured to produce an electrical signal related to heart rate of a patient, wherein the ischemia detector is configured to trend the first electrical sensor signal in relation to heart rate of the subject.

15. The system of claim 1, wherein the trigger event detector and the ischemia detector are included in an implantable medical device (IMD), wherein the IMD further includes an audible alarm circuit coupled to the ischemia detector, and wherein the ischemia detector is configured to provide an audible alarm if an episode of myocardial ischemia is declared upon detecting the second condition.

16. The system of claim 1, wherein the trigger event detector and the ischemia detector are included in an IMD, wherein the system further includes an external device adapted to communicate with the IMD, and wherein the IMD is configured to communicate an indication of myocardial ischemia to the external device.

17. The system of claim 16, wherein the external device includes a remote server in communication with the IMD over a communications or computer network.

18. The system of claim 1, further including a memory, in communication with the ischemia detector, to store a log containing information related to ischemia for a patient.

19. The system of claim 1, wherein the trigger event detector and the ischemia detector are included in an IMD, wherein the IMD further includes a therapy circuit coupled to the ischemia detector, and wherein the ischemia detector is configured to initiate a device therapy if an episode of myocardial ischemia is declared upon detecting the second condition.

20. A method comprising:

sensing one or more sensor signals produced by implantable sensors, each sensor signal including physiologic cardiovascular information;

determining at least one first condition; and

enabling detection of a second condition related to one or more physiologic cardiovascular events in a subject that are indicative of myocardial ischemia upon detecting the first condition.

21. The method of claim 20, including:

sampling the sensor signals at a first sampling rate to establish a baseline for the sensor signals; and

wherein enabling detection of the second condition includes enabling sampling of the sensor signals at a different second sampling rate.

22. The method of claim 20, wherein determining the first condition includes detecting at least one physiologic event from the group consisting of:

a) an increase in heart rate that exceeds a predetermined heart rate threshold;

b) an increase in a rate of change in heart rate exceeds a predetermined heart rate threshold value;

c) a decrease in heart rate variability (HRV);

d) a decrease in respiratory sinus arrhythmia (RSA);

e) an abnormal cardiac rhythm;

f) a predetermined decrease in patient activity level within a predetermined period of time;

g) an increase in at least one of patient exertion and patient stress; and

h) a time that is predetermined according to a patient circadian rhythm.

23. The method of claim 20, wherein determining the first condition includes determining a circadian rhythm of the subject.

24. The method of claim 20, wherein determining the first condition includes determining that an enable for detecting the second condition is communicated from an external device.

25. The method of claim 20, wherein detecting the second condition includes detecting one or more of:

a) an ST segment deviation;

b) a change in a cardiac activation sequence;

c) a change in one or more heart sound features;

d) a change in blood pressure from an established baseline blood pressure;

e) a change in right ventricle and left ventricle synchrony;

f) a change in morphology of a sensed cardiac depolarization signal;

g) a decrease in cardiac blood oxygen saturation;

h) a change in cardiac wall motion;

i) a change in transthoracic impedance;

j) a change in intracardiac impedance; and

k) a change in cardiac temperature without an accompanying detected increase in patient exertion level.

26. The method of claim 20, further including:

sampling the sensor signals;

trending the sensor signals in the presence of physiologic noise; and

using the trending to remove physiologic noise from the sampled signals.

27. The method of claim 20, further including communicating an alarm if an episode of myocardial ischemia is declared upon detecting the second condition.

28. The method of claim 20, further including updating an ischemia log for a patient if an episode of myocardial ischemia is declared upon detecting the second condition.

29. The method of claim 20, further including initiating a device therapy if an episode of myocardial ischemia is declared upon detecting the second condition.