Compositions, organisms and methodologies employing a novel human protein phosphatase
First Claim
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1. An isolated polynucleotide comprising a nucleic acid sequence which encodes a polypeptide containing the amino acid sequence depicted in SEQ ID NO:
- 2 and having a calcineurin-like phosphoesterase function.
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Abstract
This invention provides compositions, organisms and methodologies employing a novel human gene encoding a protein that has sequence homology to a consensus sequence of calcineurin-like phosphoesterase family are disclosed. The novel protein is encoded by a human gene comprising 4 exons. The human gene is localized in the 10p15 locus of human chromosome 10. The sequence similarities between the novel human protein and the consensus sequence of calcineurin-like phosphoesterases indicate that the novel human protein may function as a calcineurin-like protein phosphatase.
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Citations
16 Claims
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1. An isolated polynucleotide comprising a nucleic acid sequence which encodes a polypeptide containing the amino acid sequence depicted in SEQ ID NO:
- 2 and having a calcineurin-like phosphoesterase function.
- View Dependent Claims (2, 3, 14, 15)
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4. An isolated polynucleotide comprising a variant of a nucleic acid sequence, wherein said nucleic acid sequence encodes the amino acid sequence depicted in SEQ ID NO:
- 2, and wherein the variant and said nucleic acid sequence have at least 90% sequence identity.
- View Dependent Claims (5)
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6. An isolated polynucleotide that is capable of hybridizing under stringent conditions to the nucleotide sequence of SEQ ID NO:
- 1 or the complement thereof.
- View Dependent Claims (7)
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8-13. -13. (canceled)
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16-23. -23. (canceled)
Specification